Scientists Develop New System to Better Manage Medication Delivery
 

Scientists Develop New System to Better Manage Parkinson's Medications

the ideal system would be a dopamine agonist patch that works better than neupro or anything that bypasses the small intestine that didn't cost a fortune of the specially formulated ligquid carbidopa/levodopa. on 2nd thought, a cure would be better.

If this technology were to work, it would be really useful. But ...

The ideal extended release levodopa pill would need its own dynamic guidance system to match the peaks and troughs of levodopa demand. Just slowing down the release would be inadequate, because it doesn't take into account the body's needs.

At least with immediate release levodopa you have the opportunity 3, 4, 5 or 6 times a day to synchronize levodopa demand with supply. This can be done either by changing the size of the next dose or by changing its time.

John

i assume such a system would require adhoc 25/100, even DUOPA requires that. think of this probably will never be marketed drug like the requip you use, it provides a baseline so you never go off.

like the description that these caps float in your stomach and eventually disintegrate i assume.

wonder if rytary has same mechanism.

Yes. C/L has a half-life of about 90 minutes, whereas ropinirole has a half-life of about 6 hours.

Rytary is made up from different preparations of C/L: an immediate release bead and two extended. release types of beads. The idea being that their effects should combine to give a long lasting plateau. However, if something goes wrong and one of the beads is not absorbed properly there is no easy fix.