NeuroTalk Support Groups - maxolon for tourette syndrome

Just my experience but I've only come across one other person in years and years who was prescribed Maxolon for tics. There's really not too much in the research about it with regard to treatment of tics. I'll post what I found in PubMed.

There are some potential side-effects that I'd be really wary about.

http://www.drugdigest.org/DD/DVH/Use...axolon,00.html
Maxolon = Active Ingredients: Metoclopramide Oral
Representative Names: Clopra, Maxolon, Octamide, Reclomide, Reglan Oral

PubMed Abstract
J Am Acad Child Adolesc Psychiatry. 2005 Jul;44(7):640-6.
A randomized, double-blind, placebo-controlled trial of metoclopramide for the treatment of Tourette's disorder.
Nicolson R, Craven-Thuss B, Smith J, McKinlay BD, Castellanos FX.

Department of Psychiatry, The University of Western Ontario, London, Ontario, Canada.

Quote:

OBJECTIVE: The pattern of dopamine antagonism by metoclopramide suggests benefits in the treatment of tic disorders. The purpose of this study was to examine the efficacy and safety of metoclopramide in the treatment of children and adolescents with tic disorders.
METHOD: Twenty-seven medication-free patients (age 11.9 +/- 2.7 years) with Tourette's disorder or a chronic tic disorder participated in an 8-week double-blind, randomized, placebo-controlled trial of metoclopramide. Metoclopramide was started at 5 mg daily and titrated as needed to a maximum dose of 40 mg daily. Tics were rated every 2 weeks, and adverse effects, including weight, cardiac, and laboratory measures, were monitored.
RESULTS: After 8 weeks of treatment, subjects receiving metoclopramide showed a 39% reduction in their total tic score on the Yale Global Tic Severity Scale, while subjects receiving placebo showed only a 13% reduction in tic severity (p = .001). Metoclopramide was well tolerated with no significant laboratory or cardiac changes noted other than an increase in serum prolactin.
CONCLUSIONS: The results of this small controlled study suggest that metoclopramide is an effective and well-tolerated treatment for children and adolescents with tic disorders. Further trials are needed to confirm its efficacy and safety in pediatric patients and adults.

PubMed Abstract
J Child Adolesc Psychopharmacol. 2004 Spring;14(1):123-8.
Use of the "inverse neuroleptic" metoclopramide in Tourette syndrome: an open case series.
Acosta MT, Castellanos FX.

Department of Neurology, Children's National Medical Center, Washington, DC, USA.

Quote:

Neuroleptics are generally highly effective in suppressing tics, but their many adverse effects limit their usefulness. Animal studies have shown that, compared with both typical and atypical neuroleptics, metoclopramide has effects that are regionally circumscribed to rat motor striatum. Based on this observation and two prior case reports, metoclopramide was openly prescribed and individually titrated to diminish tics in 10 patients with Tourette syndrome. All patients improved on the Yale Global Tic Severity Scale by an average of 55%. Although we did not observe frank extrapyramidal symptoms, including tardive dyskinesia, these data are not sufficient to support clinical recommendations because of many limitations, including the absence of systematic ratings of nontic abnormal movements. However, controlled clinical studies and additional basic investigations of metoclopramide are warranted.