Bipolar basics 101...long but really informative
 

Bipolar disorder (previously known as manic depression) is a psychiatric diagnostic category describing a class of mood disorders in which the person experiences clinical depression and/or mania, hypomania, and/or mixed states. Persons suffering from the disorder are considered to be disabled.

Cases of bipolar disorder are generally divided into two diagnostic categories, Bipolar I and Bipolar II. Left untreated, bipolar disorder can be a severely disabling condition, with a risk of death through suicide.

The difference between bipolar disorder and unipolar disorder (also called major depression) is that bipolar disorder involves both elevated and depressive mood states. The duration and intensity of mood states varies widely among people with the illness. Fluctuating from one mood state to the next is called "cycling". Mood swings can cause impairment or improved functioning depending on their severity. There can be changes in one's energy level, sleep pattern, activity level, social rhythms and cognitive functioning. During these times, some people may have difficulty functioning.

Domains of the bipolar spectrum
Bipolar disorder is, almost without exception, a life-long condition that must be carefully managed throughout the individual's lifetime. Because there are many manifestations of the illness, it is increasingly being called bipolar spectrum disorder. The spectrum concept refers to subtypes of bipolar disorder that are sub-syndromal (below the symptom threshold) and typically misdiagnosed as depression. Nassir Ghaemi, M.D., has also contributed to the development of a bipolar spectrum questionnaire. The full bipolar spectrum includes all states or phases of the bipolar disorders.

Bipolar depression
The vast majority of people diagnosed with, or who may be diagnosed with, bipolar disorder suffer from clinical depression. In fact, there is at least a 3 to 1 ratio of time spent depressed versus time spent among euthymic (normal mood), hypomanic and manic states during the course of the bipolar I subtype of the illness. People with the bipolar II subtype remain depressed for substantially longer (37 times longer) according to the study findings discussed in the epidemiology section below.

According to the Mayo Clinic, in the depressive phase, signs and symptoms include: persistent feelings of sadness, anxiety, guilt or hopelessness, disturbances in sleep and appetite, fatigue and loss of interest in daily activities, problems concentrating, irritability, chronic pain without a known cause, recurring thoughts of suicide.[3]

A 2003 study by Robert Hirschfeld, M.D., of the University of Texas, Galveston found bipolar patients fared worse in their depressions than unipolar patients. (See Bipolar Depression.) In terms of disability, lost years of productivity, and potential for suicide, bipolar depression, which is different (in terms of treatment), from unipolar depression, is now recognized as the most insidious aspect of the illness.

Severe depression may be accompanied by symptoms of psychosis. These symptoms include hallucinations (hearing, seeing, or otherwise sensing the presence of stimuli that are not there) and delusions (false personal beliefs that are not subject to reason or contradictory evidence and are not explained by a person's cultural concepts). They may also suffer from paranoid thoughts of being persecuted or monitored by some powerful entity such as the government or a hostile force. Intense and unusual religious beliefs may also be present, such as patients' strong insistence that they have a God-given role to play in the world, a great and historic mission to accomplish, or even that they possess supernatural powers. Delusions in a depression may be far more distressing, sometimes taking the form of intense guilt for supposed wrongs that the patient believes he or she has inflicted on others.

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Mania
Main article: Mania
Researchers at Duke University have refined Kraepelin’s four classes of mania to include hypomania (featuring mainly euphoria), severe mania (including euphoria, grandiosity, high levels of sexual drive, irritability, volatility, psychosis, paranoia, and hostility and aggression), extreme mania (most of the displeasures, hardly any of the pleasures) also known as dysphoric mania, and two forms of mixed mania (where depressive and manic symptoms collide).[1]

The Mayo Clinic and others list as additional possible symptoms of mania: elation, extreme optimism, rapid unstoppable flow of speech, racing thoughts/flights of ideas, agitation, poor judgment, recklessness or taking chances not normally taken, inordinate capacity for activity, difficulty sleeping or lesser need for sleep, tendency to be easily distracted (may constantly shift from one theme or endeavor to another), inability to concentrate, exuberant and flamboyant or colorful dress, authoritative manner, and tendency to believe they are in their best mental state.[4]

Manic patients may be inexhaustibly, excessively, and impulsively involved in various activities without recognizing the inherent social dangers.

Symptoms of psychosis include hallucinations (hearing, seeing, or otherwise sensing the presence of stimuli that are not there) and delusions (false personal beliefs that are not subject to reason or contradictory evidence and are not explained by a person's cultural concepts). Feelings of paranoia, during which the patient believes he or she is being persecuted or monitored by the government or a hostile force. Intense and unusual religious beliefs may also be present, such as a patient's strong insistence that they have a God-given role to play in the world, a great and historic mission to accomplish, or even that they possess supernatural powers. Delusions may or may not be mood congruent.

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Mania and over-the-counter drugs
Phenylpropanolamine or (PPA) is a sympathomimetic drug similar in structure to amphetamine which is present in over 130 medications, primarily decongestants, cough/cold remedies, and anorectic agents.

A report on phenylpropanolamine from the Dept. of Psychiatry, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Pharmacopsychiatry 1988 stated:

We have reviewed 37 cases (published in North America and Europe since 1960) that received diagnoses of acute mania, paranoid schizophrenia, and organic psychosis and that were attributed to PPA product ingestion. Of the 27 North American case reports, more reactions followed the ingestion of combination products than preparations containing PPA alone; more occurred after ingestion of over-the-counter products than those obtained by prescription or on-the-street; and more of the cases followed ingestion of recommended doses than overdoses.
Some reference books have noted that some people developed mental illness symptoms after flu like symptoms, the probability or link to the over-the-counter medications they were taking for their symptoms was sometimes overlooked.

Failure to recognize PPA as an etiological agent in the onset of symptoms usually led to a diagnosis of schizophrenia or mania, lengthy hospitalization, and treatment with substantial doses of neuroleptics or lithium.
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Hypomania
Main article: Hypomania
Hypomania is a less severe form of mania, without progression to psychosis. Many of the symptoms of mania are present, but to a lesser degree than in overt mania.

People with hypomania are generally perceived as being energetic, euphoric, overflowing with new ideas, and sometimes highly confident and charismatic, and unlike full-blown mania, they are sufficiently capable of coherent thought and action to participate in everyday life.

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Mixed state
Main article: Mixed state (psychiatry)
In the context of bipolar disorder, a mixed state is a condition during which symptoms of mania (or hypomania) and clinical depression occur simultaneously (for example, agitation, anxiety, fatigue, guilt, impulsiveness, insomnia, disturbances appetite, irritability, morbid and/or suicidal ideation, panic, paranoia, psychosis, pressured speech, indecisiveness and rage). [5]

In at least 1/3 of persons with bipolar disorders, the entire attack--or a succession of attacks--occurs as a mixed episode.

Mixed states can be the most dangerous period of mood disorders, during which panic attacks, substance abuse, and suicide attempts increase greatly.

A dysphoric mania consists of a manic episode with depressive symptoms. Increased energy and some form of anger, from irritability to full blown rage, are the most common symptoms. Symptoms may also include auditory hallucinations, confusion, insomnia, persecutory delusions, racing thoughts, restlessness, and suicidal ideation.

Alcohol, drugs of abuse, and antidepressant drugs may trigger or aggravate dysphoric mania in susceptible individuals.

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Cycling
Rapid cycling, defined as having four or more episodes per year, is found in a significant fraction of patients with bipolar disorder.

Ultradian cycling, in which mood cycling can also occur daily or even hourly, is less common. (Although the concept of ultradian cycling has been accepted by many psychiatrists, whether it represents true cycling is far from established.)[6]

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Cognition
Numerous studies show that bipolar disorder affects a patient's ability to think and perform mental tasks, even in states of remission.[2] Deborah Yurgelun-Todd of McLean Hospital in Belmont, Massachusetts has argued these deficits should be included as a core feature of bipolar disorder.

By the same token, research by Kay Redfield Jamison of Johns Hopkins University and others has attributed high rates of creativity and productivity to certain individuals with bipolar disorder. (See Brain Damage.)

There may be no conflict here: Cognitive dysfunction does not necessarily bar creativity.

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Suicide risk
People with bipolar disorder are about three times[citation needed] as likely to commit suicide as those suffering from major depression (12% to 30%).[citation needed] Although many people with bipolar disorder who attempt suicide never actually complete it, the annual average suicide rate in men and women with diagnosed bipolar disorder (0.4%) is 10 to more than 20 times that in the general population [7][8]

Individuals with bipolar disorder tend to become suicidal, especially during mixed states such as dysphoric hypomania and agitated depression. Suicidal symptoms include:

Talking about feeling suicidal or wanting to die
Feeling hopeless, that nothing will ever change or get better
Feeling helpless, that nothing makes a difference
Feeling like a burden to family and friends
Putting affairs in order (for example, organizing finances (paying debts) or giving away possessions to prepare for one's death)
Putting oneself in harm's way, or in situations where there is a danger of being killed
Abusing alcohol or drugs
A patient with these symptoms (or anyone related to said patient) could do the following:

Call the patient's doctor, emergency room, or the emergency telephone number right away to get immediate help
Make sure the suicidal person (be it self or somebody else) is not left alone
Make sure access to large amounts of medication, weapons, or other items that could be used, is prevented
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Diagnosis
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Diagnostic criteria
Main article: Current diagnostic criteria for bipolar disorder
Flux is the fundamental nature of bipolar disorder. Both within and between individuals with the illness, energy, mood, thought, sleep, and activity are among the continually changing biological markers of the disorder. The diagnostic subtypes of bipolar disorder are thus static descriptions--snapshots, perhaps--of an illness in change. Individuals may stay in one subtype, or change into another, over the course of their illness. The DSM V, to be published in 2011, will likely include further subtyping (Akiskal and Ghaemi, 2006).

There are currently 4 types of bipolar illness. The DSM-IV-TR details 4 categories of bipolar disorder, Bipolar I, Bipolar II, Cyclothymia, and Bipolar Disorder NOS (Not Otherwise Specified).

According to the DSM-IV-TR, a diagnosis of Bipolar I disorder requires one or more manic or mixed episodes. A depressive episode is not required for a diagnosis of BP I disorder, although the overwhelming majority of people with BP I suffer from them as well.

Bipolar II, the more common but by no means less severe type of the disorder, is characterized by some episodes of hypomania and disabling, severe depression; crippling depression with episodes of hypomania. A diagnosis of bipolar II disorder requires at least one hypomanic episode. This is used mainly to differentiate it from unipolar depression. Although a patient may be depressed, it is very important to find out from the patient or patient's family or friends if hypomania has ever been present, using careful questioning. This, again, avoids the antidepressant problem. Recent screening tools such as the Hypomanic Check List Questionnaire (HCL-32) have been developed to assist the sometimes difficult detection of Bipolar II disorders.

A diagnosis of Cyclothymic Disorder requires the presence of numerous hypomanic episodes, intermingled with depressive episodes that do not meet full criteria for major depressive episodes. The main idea here is that there is a low-grade cycling of mood which appears to the observer as a personality trait, but interferes with functioning.

If an individual clearly seems to be suffering from some type of bipolar disorder but does not meet the criteria for one of the subtypes above, he or she receives a diagnosis of Bipolar Disorder NOS (Not Otherwise Specified).

The criteria for "major depression" may apply to unipolar or bipolar depression.

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Misdiagnosis
There are many problems with symptom accuracy, relevance, and reliability in making a diagnosis of bipolar disorder in the DSM-IV-TR. These problems all too often lead to misdiagnosis.

In fact, University of California at San Diego's Hagop Akiskal M.D. believes that the way the bipolar disorders in the DSM are conceptualized and presented routinely lead many primary care doctors and mental health professionals to misdiagnose bipolar patients with unipolar depression, when a careful history from patient, family, and/or friends would yield the correct diagnosis.

If misdiagnosed with depression, patients are usually prescribed antidepressants, and the person with bipolar depression can become agitated, angry, hostile, suicidal, and even homicidal (these are all symptoms of hypomania, mania, and mixed states).

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Treatment lag
The behavioral manifestations of bipolar disorder are often not recognized by mental health professionals, so people may suffer unnecessarily for many years (over 10 years, according to research conducted by bipolar disorders expert Nassir Ghaemi M.D.) before receiving proper treatment.

That treatment lag is apparently not decreasing, even though there is now increased public awareness of the illness in popular magazines and health websites. Recent TV specials, for example MTV's "True Life: I'm Bipolar", talk shows, and public radio shows have focused on mental illnesses thereby further raising public awareness.

Despite this increased focus, individuals are still commonly misdiagnosed. (See the 2005 American Journal of Managed Care.)

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Children
Bipolar disorder is a frequent co-morbid condition among children who have experienced early chronic maltreatment, such as physical and sexual abuse or neglect, and who have Reactive attachment disorder.

There is a strong genetic component to this disorder, and parents who severely maltreat their children are themselves likely to suffer from significant mental health issues, such as Bipolar disorder.

About 50% of children who have Reactive attachment disorder also have Bipolar I disorder. [3]. Children with Bipolar disorder often do not meet the strict DSM-IV definition, because in pediatric cases the cycling can occur very quickly (see section above on rapid cycling). [4].

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Treatment
Main article: Treatment of bipolar disorder
Currently, bipolar disorder has not been cured, though many psychiatrists and psychologists believe that it can be managed.

The emphasis of treatment is on effective management of the long-term course of the illness, which can involve treatment of emergent symptoms. Treatment methods include pharmacological and psychological techniques.

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Prognosis and the goals of long-term treatment
A good prognosis results from good treatment which, in turn, results from an accurate diagnosis. Because bipolar disorder continues to have a high rate of both underdiagnosis and misdiagnosis, it is often difficult for individuals with the illness to receive timely and competent treatment.

Bipolar disorder is a severely disabling medical condition. In fact, it is the 6th cause of disability in the world, according to the World Health Organization. However, with appropriate treatment, many individuals with bipolar disorder can live full and satisfying lives. Persons with bipolar disorder are likely to have periods of normal or near normal functioning between episodes.

The prognosis for bipolar disorder is, in general, better than that for schizophrenia. However, many atypical antipsychotics, which were originally developed to treat schizophrenia, have also been shown to be effective in bipolar mania.

Ultimately one's prognosis depends on many factors, which are, in fact, under the individual's control: the right medicines; the right dose of each; a very informed patient; a good working relationship with a competent medical doctor; a competent, supportive, and warm therapist; a supportive family or significant other; and a balanced lifestyle that includes exercise. One of the most important lifestyle changes is regular sleep and wake times; this cannot be stressed enough.

There are obviously other factors that lead to a good prognosis, as well, such as being very aware of small changes in one's energy, mood, sleep and eating behaviors, as well as having a plan in conjunction with one's doctor for how to manage subtle changes that might indicate the beginning of a mood swing. Some people find that keeping a log of their moods can assist them in predicting changes.

The goals of long-term treatment should be to help the individual achieve the highest level of functioning, and to avoid relapse.

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Relapse
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Even when on medication, some people may still experience weaker episodes, or have a complete manic or depressive episode.

The following behaviors can lead to depressive or manic relapse:

Discontinuing or lowering one's dose of medication, without consulting one's physician.
Being under- or over-medicated. Generally, taking a lower dosage of a mood stabilizer can lead to relapse into mania. Taking a lower dosage of an antidepressant, may cause the patient to relapse into depression, while higher doses can cause destabilization into mixed-states or mania.
Taking hard drugs – recreationally or not – such as cocaine, alcohol, amphetamines, or opiates. These can cause the condition to worsen.
An inconsistent sleep schedule can destabilize the illness. Too much sleep (possibly caused by medication) can lead to depression, while too little sleep can lead to mixed states or mania.
Caffeine can cause destabilization of mood toward irritability, dysphoria, and mania. Anecdotal evidence seems to suggest that lower dosages of caffeine can have effects ranging from anti-depressant to mania-inducing.
Inadequate stress management and poor lifestyle choices. If unmedicated, excessive stress can cause the individual to relapse. Medication raises the stress threshold somewhat, but too much stress still causes relapse.
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Research findings
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Heritability or inheritance
Bipolar disorder runs in families.[9] More than 2/3 of people with bipolar disorder have at least one close relative with the disorder or with unipolar major depression, indicating that the disease has a genetic component.

Studies seeking to identify the genetic basis of bipolar disorder indicate that susceptibility stems from multiple genes. Scientists are continuing their search for these genes, using advanced genetic analytic methods and large samples of families affected by the illness. The researchers are hopeful that identification of susceptibility genes for bipolar disorder, and the brain proteins they code for, will make it possible to develop better treatments and preventive interventions targeted at the underlying illness process.

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Genetic research
Bipolar disorder is considered to be a result of complex interactions between genes and environment.

The monozygotic concordance rate for the disorder is 70%. This means that if a person has the disorder, an identical twin has a 70% likelihood of having the disorder as well. Dizygotic twins have a 23% concordance rate. These concordance rates are not universally replicated in the literature; recent studies have shown rates of around 40% for monozygotic and <10% for dizygotic twins (see Kieseppa, 2004 [5] and Cardno, 1999 [6]).

In 2003, a group of American and Canadian researchers published a paper that used gene linkage techniques to identify a mutation in the GRK3 gene as a possible cause of up to 10% of cases of bipolar disorder. This gene is associated with a kinase enzyme called G protein receptor kinase 3, which appears to be involved in dopamine metabolism, and may provide a possible target for new drugs for bipolar disorder.[7]

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Ongoing research
The following studies are ongoing, and are recruiting volunteers:

The Maudsley Bipolar Twin Study, based at the Institute of Psychiatry in London is conducting research about the genetic basis of bipolar disorder using twin methdology. Currently recruiting volunteers: identical and non-identical twins pairs, where either one or both twins has a diagnosis of bipolar I or II.

The MRC eMonitoring Project, another research study based at the Institute of Psychiatry and Newcastle Universities, is conducting novel research on electronic monitoring methodologies (electronic mood diaries and actigraphy) for tracking bipolar symptom fluctuations in Bipolar individuals who are interested in self-managing their condition.

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Medical imaging
Researchers are using advanced brain imaging techniques to examine brain function and structure in people with bipolar disorder, particularly using the functional MRI and positron emission tomography. An important area of neuroimaging research focuses on identifying and characterizing networks of interconnected nerve cells in the brain, interactions among which form the basis for normal and abnormal behaviors. Researchers hypothesize that abnormalities in the structure and/or function of certain brain circuits could underlie bipolar and other mood disorders, and studies have found anatomical differences in areas such as the prefrontal cortex[8] and hippocampus.

Better understanding of the neural circuits involved in regulating mood states, and genetic factors such as the cadherin gene FAT linked to bipolar disorder,[9] may influence the development of new and better treatments, and may ultimately aid in early diagnosis and even a cure.

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Personality types or traits
An evolving literature exists concerning the nature of personality and temperament in bipolar disorder patients, compared to major depressive disorder (unipolar) patients and non-sufferers. Such differences may be diagnostically relevant. Using MBTI continuum scores, bipolar patients were significantly more extroverted, intuitive, and perceiving, and less introverted, sensing, and judging than were unipolar patients[citation needed]. This suggests that there might be a correlation between the Jungian extraverted intuiting process and bipolar disorder.

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New treatments
In late 2003, researchers at McLean Hospital found tentative evidence of improvements in mood during echo-planar magnetic resonance spectroscopic imaging (EP-MRSI), and attempts are being made to develop this into a form which can be evaluated as a possible treatment.[10],[11]

NIMH has initiated a large-scale study at 20 sites across the U.S. to determine the most effective treatment strategies for people with bipolar disorder. This study, the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), will follow patients and document their treatment outcome for 5-8 years. For more information, visit the Clinical Trials page of the NIMH Web site[10].

Transcranial magnetic stimulation is another fairly new technique being studied.

Pharmaceutical research is extensive and ongoing, as seen at clinicaltrials.gov.

Gene therapy and nanotechnology are two more areas of future development.

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Causes (Etiology)
According to the US government's National Institute of Mental Health (NIMH), "There is no single cause for bipolar disorder—rather, many factors act together to produce the illness." "Because bipolar disorder tends to run in families, researchers have been searching for specific genes—the microscopic "building blocks" of DNA inside all cells that influence how the body and mind work and grow—passed down through generations that may increase a person's chance of developing the illness." "In addition, findings from gene research suggest that bipolar disorder, like other mental illnesses, does not occur because of a single gene." [11].

It is well established that bipolar disorder is a genetically influenced condition which can respond very well to medication (Johnson & Leahy, 2004; Miklowitz & Goldstein, 1997; Frank, 2005). (See treatment of bipolar disorder for a more detailed discussion of treatment.)

Psychological factors also play a strong role in both the psychopathology of the disorder and the psychotherapeutic factors aimed at alleviating core symptoms, recognizing episode triggers, reducing negative expressed emotion in relationships, recognizing prodromal symptoms before full-blown recurrence, and, practicing the factors that lead to maintenance of remission (Lam et al, 1999; Johnson & Leahy, 2004; Basco & Rush, 2005; Miklowitz & Goldstein, 1997; Frank, 2005). Modern evidence based psychotherapies designed specifically for bipolar disorder when used in combination with standard medication treatment increase the time the individual stays well significantly longer than medications alone (Frank, 2005). These psychotherapies are Interpersonal and Social Rhythm Therapy for Bipolar Disorder, Family Focused Therapy for Bipolar Disorder, Psychoeducation, Cognitive Therapy for Bipolar Disorder, and Prodrome Detection. All except psychoeducation and prodrome detection are available as books.

Brain scientist Husseini K. Manji M.D. of the NIMH states that at their most basic level, the bipolar disorders involve problems in brain structure and function. He stated that these structural changes respond very well to treatment with lithium and valproate in a University of California, Los Angeles Neuropsychiatric Institute (NPI) Grand Rounds Talkgiven in 2003 (requires Real Player and a high-speed internet connection).

Early in the course of the illness brain structural abnormalities may lead to feelings of anxiety and lower stress resilience. When faced with a very stressful, negative major life event, such as a failure in an important area, an individual may have his first major depression. Conversely, when an individual accomplishes a major achievement he may experience his first hypomanic or manic episode. Individuals with bipolar disorder tend to experience episode triggers involving either interpersonal or achievement-related life events. An example of interpersonal-life events include falling in love or, conversely, the death of a close friend. Achievement-related life events include acceptance into an elite graduate school or by contrast, being fired from work (Miklowitz & Goldstein, 1997).

Veteran brain researcher Robert Post M.D. of the U.S. NIMH proposed the "kindling" theory [12] which asserts that people who are genetically predisposed toward bipolar disorder experience a series of stressful events, each of which lowers the threshold at which mood changes occur. Eventually, the mood episode starts (and becomes recurrent) by itself. Not all individuals experience subsequent mood episodes in the absence of positive or negative life events, however.

Individuals with late-adolescent/early adult onset of the disorder will very likely have experienced childhood anxiety and depression. Childhood onset bipolar disorder should be treated early because according to Joseph Calabrese of Case Western Reserve University, childhood forms of the illness may be easier to treat than adult forms of the illness. (See his University of California, Los Angeles NPI Grand Rounds Talk on rapid-cycling in October 2003.)

It is becoming increasingly clear that bipolar and unipolar mood disorders have a genetic component. For example, a family history of bipolar spectrum disorders can impart a genetic predisposition towards developing a bipolar spectrum disorder[13]. Since bipolar disorders are polygenic (involving many genes), there are apt to be many unipolar and bipolar disordered individuals in the same family pedigree. This is very often the case (Barondes, 1998). Anxiety disorders, clinical depression, eating disorders, premenstrual dysphoric disorder, postpartum depression, postpartum psychosis and/or schizophrenia may be part of the patient's family history and reflects a term called "genetic loading".

Bipolar disorder is more than just biological and psychological. Since "many factors act together to produce the illness", bipolar disorder is called a multifactorial illness, because many genes and environmental factors conspire to create the disorder (Johnson & Leahy, 2004).

Since bipolar disorder is so heterogeneous, it is likely that people experience different pathways towards the illness (Miklowitz & Goldstein, 1997).

Hi Bizi,

I had read most of this post earlier today and for some reason left. It is a lot to take in my wandering mind. I did get a lot of of it though Thank you. I wonder if bi-polar gets better with age?

befuddled2

I am sorry this is so long perhaps I should edit this?
good for you for trying to get thru some of it.
(((HUGS)))
bizi

Hi bizi,

I think your post is good the way it is. It is comprehensive and what I didn't think related to me I kind of skimmed over or skipped. Someone might take what I left.

befuddled2

Hey- thanks for this! Interesting. Still working through my new diagnosis. ....

That is a great post. Very interesting and very true. As far as how much or how little I really know.

I saw myself there too.

Thanks for sharing.

Hugs, Nikko

the top 10 myths about bipolar disorder

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By John McManamy

Like many mental illnesses, the commentary surrounding bipolar disorder is saturated with myths--it's hard to tell what's true and what's not. Below you'll find the real story, from our expert patient John McManamy.

1. Everyone has their ups and downs, so mine aren’t that serious.

Yes, everyone has good days and bad days, but when these ups and downs seriously interfere with your ability to work, relate to others and function effectively, it is advisable to seek out a psychiatrist.

2. Bipolar disorder is a mood disorder.

Half true. Bipolar disorder certainly affects mood, but it also affects cognition and the ability to perform mental tasks. Some days we can out-think Stephen Hawking. Other days we make Forrest Gump look like an intellectual.

3. Yes, but bipolar disorder is still a mood disorder.

Granted, but for most of us it is also part of a package deal that may include anxiety, substance and alcohol abuse and sleep disorders. Also, researchers are finding smoking guns linking the illness to heart disease, migraines and other physical ailments.

4. Bipolar disorder is characterized by mood swings ranging from severely depressed to wildly manic.

Not necessarily. Most people with bipolar disorder are depressed far more often than they are manic. Often, the manias are so subtle that they are overlooked by both patient and psychiatrist, resulting in misdiagnosis. People with bipolar disorder can also enter long periods of remission.

5. Mania is like being on top of the world—if you could only put it in a bottle and sell it.

You wouldn’t want to with most manias. True, some forms of mild mania are characterized by feelings of elation, but other types have road rage features built in. More severe mania turns up the heat, resulting in different kinds of out-of-control behavior that can ruin your career, relationships and reputation.

6. Bipolar disorder is caused by a chemical imbalance of the brain.

This is the simpler explanation—what you tell your family and friends. What you need to know is our genes, biology and life experience make us extremely sensitive to stress. Various stressors, such as personal relationships and financial worries, have the potential to trigger a mood episode if not effectively nipped in the bud.

7. Medications are all you need to combat bipolar disorder.

False. While medications are the foundation of treatment for bipolar disorder, recovery is problematic without a good lifestyle regimen (diet, exercise and sleep), effective coping skills and a support network. People with bipolar disorder also benefit from various forms of talking therapy and religious/spiritual practice.

8. Medications don’t work for me.

For some people this may be true, but we all need to give our meds a chance. Treatment guidelines anticipate initial failures, and while no two guidelines are in agreement they are all based on the premise that eventually you will find a medication or combination of medications that will help you.

9. Lower quality of life and sluggish cognition are fair trade-offs for reducing mood symptoms.

False, big time. In the initial phase of treatment, meds overkill may be justified to bring your illness under control. But full recovery is based on improving your overall health and ability to function, not just eliminating mood symptoms. Over time, the side effects of medication tend to go away, so patience is advised. You may choose to live with minor side effects such as mild hand tremors. But if major side effects persist, you should work with your psychiatrist in adjusting doses or switching to different meds. The onus is on you to alert your psychiatrist to major side effects and to insist he or she take appropriate action.

10. Once you’ve been diagnosed with bipolar disorder, you can forget about leading a normal life.

False. Living with bipolar disorder is a challenge, and you may have to change your expectations, but you should never give up on living a rewarding and productive life.

Newly diagnosed...1st 48 hours
 

newly diagnosed?

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The First 48 Hours with Bipolar Disorder

By John McManamy

You never find happy individuals walking into a psychiatrist’s office for the first time. People with bipolar disorder only seek help when their life is going terribly wrong or when their brains have taken them hostage. Your situation is probably looking pretty bleak at the moment, and the last thing you need to be told is you are not normal—whatever normal is. "How can I live with a brain I can’t trust?" you may be wondering. "How can I face my family and friends and colleagues—the ones who are still talking to me, anyway? Will I ever be able to get my old life back, or what’s left of it?"

At the same time, you may be feeling an overwhelming sense of relief. Finally, someone has fingered your invisible nemesis and given it a name. Suddenly your whole life begins to make sense, and it has nothing to do with any moral or character weakness on your part. You’ve smoked the beast out into the open. For the first time in your life, you have a fighting chance.

But let’s not kid ourselves. Bipolar disorder takes no prisoners. You’re going to have to fight this with all you’ve got. Here’s what you need to know now that you’ve been diagnosed.

Your Psychiatrist Is Your Partner, Not Your Boss

Your psychiatrist has probably sent you out of the office with a prescription for one or more psychiatric medications. [Read more about medications and drug information.] If you’re one of the lucky ones, the meds will work like a charm. Most likely, an extended adjustment period lies ahead. For starters, you are biologically unique, and no two cases of bipolar are the same. What works for one person may not work for you. Second, medications for bipolar disorder are by no means perfect. They may only get you half-well for now, and you may have to contend with troublesome side effects.

You have already passed your biggest hurdle: you sought help. Now comes your second-biggest hurdle: forging a working partnership with your psychiatrist. Forget about being a passive patient. Treating bipolar disorder is not the equivalent of taking statins and watching your cholesterol go down—if only life were that simple. All too often, patients quit in frustration when their meds aren’t working right, only to find themselves back in crisis days or weeks or even months later. Often, the problem lies with a psychiatrist who doesn’t listen. More often than not, the patient neglects to speak up.

The onus is on you. Psychiatrists these days have severe constraints on their time. If you don’t badger them, they won’t ask that vital extra question. Remember, psychiatrists are only as good as what you tell them. This is no time to be shy. Here’s a brief list of what I consider to be your rights as a patient:

1. Your psychiatrist has a duty to listen. If you feel this is not happening, find one who does.

2. The American Psychiatric Association, in its 2000 Bipolar Treatment Guidelines, stipulates that the goal of treatment is to achieve remission. The APA goes on to say that this means having virtually no symptoms and functioning fully. Basically, your psychiatrist writing you off is not an option, no matter how bad things may be going for you at the time.

3. You should not have to settle for dulled cognition and a diminished capacity to enjoy life as the price of reduced mood symptoms. Many side effects of major medication tend to go away as your body adjusts to the meds, and you should allow for this. But you should not have to put up with meds that make you feel worse. You can discuss the side effects of bipolar meds on our message boards.

4. You have the right to give your psychiatrist the third degree concerning every medication he or she may prescribe. If you are not satisfied with the answers, you have the right to refuse to take that particular medication or medications.

5. Less may be more. It's overkill is justifiable for a crisis, but is not the right strategy for long-term recovery. There may be valid reasons for remaining on many meds in high doses, but the onus should be on your psychiatrist to provide satisfactory explanations.

6. You’re entitled to timely responses from your psychiatrist. Phone messages should be returned at first opportunity, and your psychiatrist should be available in a crisis.

If you have just been diagnosed, you are probably in a crisis, or are just emerging from one. For the time being, your psychiatrist will be the lead partner. But once you start moving into the recovery phase, you need to show some initiative. Only an equal partnership will get the job done.

Lifestyle Is Just As Important As Meds

You may not want to commit yourself to an improved lifestyle regimen the way you are feeling right now, but your new meds may force you to take immediate action.

Some medications are notorious weight-gainers, and patients are often caught by surprise, with no warning from their psychiatrists. It is not uncommon for patients to put on 20 pounds in a matter of weeks or months and 60 pounds over a year. Sudden weight gain works against the intended result of medications, as the extra pounds contribute to feelings of sluggishness and low self-esteem, which are symptoms of depression. You may have no choice but to take these meds, but you do have the choice to start eating low-fat food. As soon as you’re able, you can work on a more permanent diet and nutrition strategy.

It is wise to cut down on “mood-buster” foods. A 20-oz Coke contains 15 teaspoons of sugar. Sugar has been linked to depression and mood spikes and crashes. Caffeine should be used sparingly and alcohol only with your doctor’s permission. Think before you drink (and eat). Folates, omega-3s, and various vitamins and minerals, on the other hand, have been linked to improved mood and brain function.

Just about everyone with a mood disorder has a sleep problem; they either are unable to fall asleep or sleep too much. A missed night’s sleep can trigger a manic episode. Staying in bed can make depression worse. Sticking to some kind of regular schedule is vital, and establishing sound sleep hygiene is a must. Once sleep is resolved, often with the aid of medications, many mood and cognitive symptoms clear up.

Exercise has been linked to improved mood and brain function, increased energy and higher self-esteem. A regular exercise routine is an essential part of your wellness strategy, though right now you are probably in no shape to make the effort. Resolve to start small, perhaps with a five-minute walk, and add more as you progress through recovery.

Spiritual and religious practice has been linked to improved physical and mental health. This may be because prayer and meditation kick-start a number of beneficial biological processes. Then again, it could be pure God-power. You may feel God has abandoned you right now, but don’t be afraid to rekindle the relationship.

Read more about Therapy and Lifestyle Changes.

Support Is Vital

Whether or not to disclose your illness to family, friends and colleagues is a tough call. Bipolar disorder still carries a heavy stigma that could result in your losing companionship and employment. For good reason, most patients choose to keep their illness a secret from their employers. But your job may be at risk if you don’t clue your employer in on your situation. You may need certain accommodations in order to keep working, such as flexible hours, and you may be surprised at how enlightened some employers can be. If you choose to disclose the information, do it through your organization’s human resources department.

Bipolar disorder is a burden you shouldn’t carry alone. You will almost certainly need to disclose your condition to selected family and friends. Finding a network of people who share your illness is also essential. You are in the right place with this online community. You can find support through our message boards as well as a comprehensive list of other sites that offer support on our support groups page. Face-to-face support is also strongly recommended. The Depression and Bipolar Support Alliance has 1,000 support groups throughout the United States.

Coping Is Your Survival Tool

Over time, you will pick up an invaluable array of coping skills. Learning from fellow patients (such as people you meet in a support group) will help you avoid mistakes others have already made. Successful patients are acutely attuned to the subtleties of their moods and behaviors, and can often nip potential episodes in the bud, before they reach the point of no return. Sometimes it’s as simple as ensuring you get a good night’s sleep or some strategic downtime.

Any practice aimed at reducing stress is worth checking out. This includes meditation, yoga, breathing exercises, relaxation exercises, physical exercise, quality time to yourself, and selectively disengaging from potentially stressful family and work situations.

There are three main types of talking therapy aimed at helping you cope: cognitive therapy, behavioral therapy and interpersonal therapy. These therapies are about the “here and now.” They do not get inside your head. By the end of 12 or so sessions, you will be on your way to turning your “It’s the end of the world” thoughts into “Let’s find a solution.” Read more about therapy here.

Over the long term you may want to seek out talking therapy to help you resolve deep-seated trauma and abuse and other issues, but now is not the time. You are in no shape right now to deal with bad memories and past and present injustices. Work on getting stabilized first. If you are in a toxic working environment or a bad marriage, your meds aren’t going to make your life better. They will help get you back on your feet, but you will find yourself right back in bed or bouncing off walls if you don’t work on correcting the underlying problems.

Isolation Kills

Perhaps worse than the illness is the isolation it brings on. The depressed phase of our disorder turns us into wounded animals seeking the solace of a quiet cave. The manic phase is all about how to lose friends and alienate people. Add to that the stigma and the shame of bipolar disorder, and suddenly Robinson Crusoe looks like a party animal. Once deprived of meaningful human contact, the illness tends to feed on itself, starting a destructive cycle that sends us deeper into depression and robs us of the social skills needed to successfully negotiate stressful situations.

You may be in no mood to talk to others right now, but you can resolve to get out of the house once a day. You may be unable to work, but this should not stop you from performing volunteer work. You may despise egotistical loudmouths, but this should not prevent you from seeking out kindred spirits.

Finally, You Are Not a Helpless Bystander

By now you have learned that meds are just one part of the picture. The bad news is they are unlikely to get the entire job done. The good news is there is a lot you can do to help yourself.

You have just survived a horrific experience and are not yet out of the woods. Please take comfort in the fact that you are much stronger than you think. Living with bipolar disorder will always be a test, but a meaningful and productive life is not out of your reac—however, different it may turn out from your original expectations. Be hopeful. We all hate our illness, but we hardly hate what this illness has made of us. Yes, we would all trade it in in a heartbeat, but we would choose to hold on to the wisdom and insight and deeper sense of humanity and divinity we picked up along the way.

Live smart. Be well.

Hypomania...long but worth the effort!
 

Hypomania
From Wikipedia, the free encyclopedia

This article is an expansion of a section entitled Hypomania from within the main article: Bipolar disorder
Hypomania is a state involving a combination of: elevated mood, irritability, racing thoughts, people-seeking, hypersexuality, grandiose thinking, religiosity, and pressured speech. Bipolar II Disorder is characterized by states of hypomania and depression. Hypomania is a less severe form of mania without progression to psychosis. Many of the symptoms of mania are present, but to a lesser degree than in overt mania. People with hypomania are generally perceived as being energetic, euphoric, overflowing with new ideas, and sometimes highly confident and charismatic, and unlike full-blown mania, they are sufficiently capable of coherent thought and action to participate in everyday life.

Although the DSM-IV-TR classifies hypomania as a mood episode, it is only considered part of bipolar disorder in the context of cycles into depression or more severe mania. A small percentage of the population may experience hypomania without ever having experienced depression or mania. Although some of these people may require treatment or therapy, according to DSM criteria they do not have bipolar disorder.

John D. Gartner's The Hypomanic Edge (Simon and Schuster) "draws a line between hypomania - recognized by such markers as inflated self-esteem, a decreased need for sleep, and episodes of risky behavior - and its far more dangerous cousin, mania." He then goes on to illustrate his thesis that there may be an "up" side to the less dangerous hypomania. His thesis includes a strong link between "(a little) Craziness and (a Lot of) Success." Gartner contends that many famous people including Christopher Columbus, Alexander Hamilton, Andrew Carnegie, Louis B Mayer, and Craig Venter (who mapped the human genome) owed their ideas and drive (and eccentricities) to their hypomanic temperaments (it is called the hyperthymic temperament in clinical research). It is questionable whether hypomania occurs without being part of a cycle of mania or depression. Patients rarely, if ever, seek out a psychiatrist complaining of hypomania. The creativity and risky behavior associated with hypomania (and bipolar disorder in general) may suggest why it has survived evolutionary pressures.

Although hypomania sounds in many ways like a desirable condition, it can have significant downsides. Many of the negative symptoms of mania can be present; the primary differentiating factor is the absence of psychosis. Many hypomanic patients have symptoms of disrupted sleep patterns, irritability, racing thoughts, obsessional traits, and poor judgment. Hypomania, like mania, can be associated with recklessness, excessive spending, risky hypersexual activity, general lack of judgment and out-of-character behaviour that the patient may later regret and may cause significant social, interpersonal, career and financial problems.

Hypomania can also signal the beginning of a more severe manic episode, and in people who know that they suffer from bipolar disorder, can be viewed as a warning sign that a manic episode is on the way, allowing them to seek medical treatment while they are still sufficiently self-aware before full-blown mania occurs.



Deceptive Hypomania: Energies Bop, Inhibitions Drop, Ideas Pop


by John McManamy
Thursday, February 23rd, 2006
No one wants to be depressed. Everyone, on the other hand, wants to be hypomanic. Think of hypomania as “mania lite,” for the time being, an elevated mood state that is better than any recreational drug high. Energies bop, inhibitions drop, ideas pop. This is the kind of personality makeover we all pray will happen to us – salesperson of the month productivity combined with life-of-party sociability.

So “right” does hypomania feel to most of us that we are inclined to mistake this state of well-being for our normal selves, Life is a cabaret. Who wants the party to stop? Not surprisingly, psychiatrists never encounter individuals walking into their office for the first time complaining of hypomania.

Psychiatrists and therapists inevitably wag their finger at the mention of hypomania. They’ve seen the consequences in far too many of their patients and clients. Sure, mild hypomania may make us the envy of the human race, but ratchet up the mood a degree or two and we start doing stupid things, make stupid decisions. This may range from spending way too much money to sleeping around to dancing on tables.

Now trouble is brewing. Overly hypomanic individuals are well on the way to destroying their finances, their relationships, their careers, and more, with no insight into the risks they are exposing themselves to. The cabaret is out of control. Life is a parody rather than a party. Events and conversations become out of sync and decidedly unpleasant. No one understands. Everyone is stupid. It’s all their fault. Anger erupts. Voices are raised …

The roller coaster ride is about to begin in earnest. For some, the crash into depression may happen. For others, the terror of full-blown mania is about to take hold.

And there is the psychiatrist or therapist, with knowing looks, saying, “I told you so.”

But how much does psychiatry truly know about hypomania? The answer is surprisingly – and inexcusably – precious little. The pioneering clinician Emil Kraepelin indentified hypomania in his classic 1920 opus, but until last year no book appeared with the term in the title.

Studies on hypomania are virtually nonexistent, absolutely ZERO clinical trials have been done on treating patients with hypomania, treatment guidelines are entirely silent on this critical phase of the illness, and the DSM provides precious little guidance.

One result is some overly-cautious psychiatrists who err on the side of overmedicating us. Patients then complain to their clinically deaf psychiatrists about feeling like zombies and having to put up with other burdensome side effects. Frustrated, these patients may quit on their meds, with predictable results.

And there’s the psychiatrist, knowing wagging his finger, blaming the poor patient.

In the next several blogs, we will discuss how some experts are challenging commonly-held assumptions, and what they are recommending to patients. Yes, hypomania poses a real danger, but for some of us it may be close to our true baseline, part of our true temperament. Are the people who treat you aware of this? Are they doing anything about it?

Hypomania Part II: What It Means for Depression Treatment


by John McManamy
Monday, February 27th, 2006
Conventional wisdom states that hypomania (see my Feb 23 blog) is a psychopathology that needs to be avoided at all costs. Surprisingly, a literal reading of the DSM does not give that impression.

You could have knocked me over with a feather when, a few years back, I carefully read what the DSM had to say about hypomania. There was the usual laundry list of symptoms, but nowhere was it expressly stated that hypomania ALONE automatically justified admission to the bipolar club. Instead, says the DSM, hypomania needs to be tag-teamed with depression to qualify for the diagnosis of bipolar II. (For bipolar I, mania alone will do.)

This means if your psychiatrist first sees you when you feel like Shizuka Arakawa after winning a gold medal in figure skating then he or she needs to probe for a history of depression. The catch is no one books emergency visits to psychiatrists when they are feeling on top of the world.

Typically, patients seek help when they are depressed. But it is impossibly difficult for individuals who feel depressed to accurately recall those times in their lives when they felt normal or better than normal. Not surprisingly, according to a 1994 DBSA survey and corroborated in subsequent studies, it takes a bipolar patient about 10 years from the time he or she first seeks help to the time his or her psychiatrist (typically the third or fourth one) arrives at a correct diagnosis.

Just to make matters slightly more confusing: There is a very strange DSM diagnosis called bipolar NOS (not otherwise specified) that does give psychiatrists discretionary leeway, but you only have to imagine NOS being applied to criminal law (murder NOS) or quantum physics (itty-bitty small particles NOS) to see the absurdity of this classification.
So hypomania gives us a valuable insight into treating depression. But what about the hypomania, itself. Does hypomania truly justify treatment? And if so, how should it be treated? You would be amazed at what even the experts don’t know.

Hypomania Part III: Can Too Much Hypomania Be Bad For You?


by John McManamy
Monday, March 6th, 2006
In a provocative and important book published last year, “The Hypomanic Edge: The Link Between (A Little) Craziness and (A Lot) of Success in America,” John Gartner, Ph.D. of Johns Hopkins contends that in many individuals hypomania needs to be regarded more as a positive personality temperament than a pathology.

These are America’s success stories, your visionaries and go-getters who are “up” practically all the time without being too far up and who are down only when temporarily sidelined due to their own excesses.

What initially hooked me on the book was that I used to be a financial journalist, and that Dr. Gartner was writing about the very people I used to interview. In a pilot study he conducted, Dr. Gartner surveyed 10 Internet CEOs, and asked them to rate on a scale of one to five how certain personality traits (such as “feels brilliant, special, chosen, perhaps even destined to change the world”) applied to them. “Many,” he reported, “gave ratings that were right off the chart … One subject repeatedly begged me to let me give him a seven.”

Bipolar disorder is more prevalent in the US than in Europe, says Dr. Gartner, and his theory to explain this is that it took driven individuals who were crazy enough to risk their lives to leave their familiar surroundings at home for an uncertain future on a strange shore. Their genes live on in today’s generation of bright sparks, entrepreneurs and political and religious zealots.

In this context, genetic transmission refers to temperament as well as a biological predisposition to mental illness. In Darwinian terms, the risk of full-blown mania and depression justified the positive benefit in passing on high-performance DNA to the next generation.

Dr. Gartner illustrates his thesis by examining the lives of a number of figures who explored, settled, founded and otherwise defined America. Queen Isabella’s advisers, for example, thought Columbus was mad for more reasons than simply wanting to sail west to reach the East (such as wanting to use the profits from his venture to fund a new Crusade). The Puritans were religious fanatics, but they were also entrepreneurs whose “risk capital” amounted to their very lives.

Then there was Alexander Hamilton, who led a foolhardy charge at Yorktown, saved a fledgling nation from bankruptcy, set the scene for US capitalism and foolishly stopped Aaron Burr’s bullet. Yes, too much hypomania can be bad for you.

There was no keeping Andrew Carnegie down. A dirt-poor immigrant with big ambitions, young Carnegie came to the attention of his superiors by showing initiative and breaking the rules. He broke yet more rules by getting into steel in the middle of an economic depression. The rest is history.

Movie mogul Louis B. Mayer played golf five balls at a time, while geneticist Craig Ventner mapped the human genome years ahead of schedule, only to get fired from the company he founded. Hypomanic individuals can be a wacky and wild lot.

As Dr. Gartner’s book makes clear, even successful individuals with hypomanic temperaments can engage in self-destructive behavior. Treatment may be justified, but intervention shouldn’t be equated with medicating the personality out of individuals. This is what so many of our population are fearful of.
But lest we confuse hypomania with an exuberant joy ride, first we need to look at its dark side.

Hypomania Part IV: It Can Make Us Want to Crawl Out of Our Own Skin


by John McManamy
Friday, March 10th, 2006
Hypomania is not all fun and games.

While working on technical update to the DSM, Trisha Suppes MD, PhD of the University of Texas Medical Center in Dallas carefully read its criteria for hypomania, and had an epiphany. “I said, wait,” she told a UCLA grand rounds lecture in April 2003, “where are all those patients of mine who are hypomanic and say they don’t feel good?”

These are your typical road rage cases. Why was there no mention of that in hypomania? Dr Suppes wondered. A subsequent literature search yielded virtually no data.

The DSM defines hypomania as “a distinct period of persistently elevated, expansive, or irritable mood.” Note that overlooked word, irritable. We’re not talking about letting the good times roll. In an irritable state, depression symptoms typically intrude into hypomania, what is called a “mixed” state. Unaccountably, although the DSM acknowledges mixed states in full blown mania, it is silent on the phenomenon in hypomania.

Many of us wind up spending a good deal of our lives feeling miserable in hypomania, and in a study published in the October 2005 Archives of General Psychiatry, Dr. Suppes provided proof. Drawing from patients in seven clinics associated with the Stanley Foundation Bipolar Treatment Network, Dr. Suppes found that the majority of hypomanic patients “met criteria for mixed hypomania,” that is at least mild hypomania combined with at least mild depression.

Meanwhile, in a study published in Bipolar Disorders the same month, Hagop Akiskal, MD of the University of California, San Diego and Franco Benazzi, MD of the Hecker Outpatient Center (Ravenna) found individuals with “dysphoric hypomania” experienced more agitated depressions by a wide margin than “pure” bipolar II patients.

I see these individuals in my support group all the time, and I am often one of them. We tend not to feel comfortable in our own minds and own bodies, as if we need to crawl out of our skin. It’s as if our brains had a minor power surge and power outage at the same time. Predictably, we are not prime candidates for Miss Congeniality. This is where you want to throw Richard Simmons off the Carnival Cruise ship. Okay, many normal people feel that way, too, but in this state of mind you want to do it in waters frequented by sharks who are slow picky eaters.

The authors of both studies observe that because clinicians are under the misconception that hypomania is supposed to be euphoric, misdiagnosis is common. People who should be diagnosed as bipolar II instead are classified as having unipolar depression or some kind of personality disorder, then are put on the wrong treatments. (To learn more about treatments for depression, read our treatment guide.)

Not that we know the right treatments. There are no major studies involving treating patients with mixed hypomania, much less any mention in any of the treatment guidelines.

For this, the dark side of hypomania, we are truly in the dark ages.

Hypomania Part V: How Little We Really Know


by John McManamy
Thursday, March 16th, 2006
The conventional view is that hypomania is part of an illness rather than our true personality, and so requires medical intervention.

But hold on, you’re Alexander Hamilton and you’ve just come up with a brilliant plan that will guarantee a new nation’s solvency for generations to come. But there’s also this insufferable prat named Aaron Burr who is bugging the hell out of you.

Now imagine you’re Hamilton’s psychiatrist. Do you reach for the Zyprexa?

Not so fast, says John Gartner, PhD, author of The Hypomanic Edge: The Link Between (a Little) Craziness) and (a Lot of) Success in America. Rather than part of an illness, Dr Gartner contends that in many individuals hypomania may be a true part of a person’s temperament – the good, the bad, and the ugly. Yes, it may be okay to reach for the prescription pad to tone down Hamilton just a tad – just enough to keep his hot head from getting hotter – but not enough to medicate the brilliance out of him.

That was the gist of an interview I had last year with Dr. Gartner. His remarks came to me as such a breath of fresh air that I could only think, “Man, the psychiatric establishment is going to hate this guy.”

I did my own research and what I found – or rather didn’t find – truly dismayed me: A PubMed search from May last year revealed only 652 article entries for hypomania vs 19,537 for mania and 176,667 for depression. There were no published clinical trials for treating patients with hypomania, and no information in any of the treatment guidelines on what to do for patients in this state of mind.

In short, psychiatry has no authority – zero, zip, nada – for treating patients with hypomania, an extremely frightening thought considering how common this phase of the illness is. Standard practice, instead, involves extrapolating from studies and clinical experience involving patients having manic episodes. These tend to be your 911 cases who generally require meds overkill to bring them out of danger.

But Alexander Hamilton was not a 911 case, though we know he was a slowly ticking time bomb. What do we do? Dr. Gartner likens the situation to the pitcher in Bull Durham with the 100 MPH fast-ball who keeps beaning the mascot. We want to slow him down a little bit so he has control, but not so he throws at 50 MPH. Dr. Gartner refers to this as “taking the edge off of the edge.”

This may involve careful micro-adjustments with small doses until you and your psychiatrist find the sweet spot. The sweet spot for you may be mildly hypomanic, with room to cycle down as well as shift sideways into occasional grumpy periods – in short, you. It feels right and you feel reasonably safe.

It’s a different story if you don’t feel reasonably safe. Many people only know hypomania as the prelude to something dreadful about to happen, either as the beginning of an ascent into mania or the start of a long drop into depression. If you’re one of these individuals, you already know that immediate and unequivocal meds intervention is a must.

Psychiatrists have good reason to be fearful of hypomania. But we often tend to fear most the things we know least. Oh, how little we know.

Hypomania Part VI: Coping


by John McManamy
Friday, March 31st, 2006
In previous blogs, I pointed out how frighteningly little the psychiatric profession knows about hypomania and its treatment. The best information we have, believe it or not, comes from our fellow patients.

In an eye-opening article in the March 2005 Australian and New Zealand Journal of Psychiatry, Sarah Russell PhD of the Melbourne-based Research Matters reported on her survey of 100 bipolar patients who were doing well and what they did to stay well. So novel was the idea of a researcher actually seeking advice from patients that I awarded Dr Russell with “Study of the Year” honors in a newsletter I publish.

Dr Russell’s findings were recently expanded into a small but highly informative book, A Lifelong Journey: Staying Well with Manic Depression/Bipolar Disorder. The book deals with how patients successfully manage all phases of their illness, but what they have to say about controlling their swings into hypomania is particularly insightful:

Jodie, who has been free of serious episodes for three years, has learned to take her pills without resentment, has limited her social activities and involvement in various projects, and has established a regular sleep schedule and other routines. Especially important, Jodie has developed “the capacity and insight to see episodes coming on.” For example, when she finds herself talking very quickly and craving excitement, she implements her “action plan.”

By the time the hypomanic good times start to roll, Dr. Russell points out, it’s generally too late for most of us. Instead, the people she talked to were microscopically attuned to far more subtle shifts in their moods and behaviors and energy levels, as well as their environment. Rather than simply taking their meds and forgetting about their illness (an impression created by their doctors), patients would “move swiftly to intercept a mood swing.” Moving swiftly often meant a decent night’s sleep and other strategic stop and smell the roses moments.

Susie, for instance, knows her main triggers are family stress and caffeine. When she finds herself buying more than one lotto ticket, visiting adult bookshops and writing late at night, she goes to battle stations. This includes limiting her coffee, restricting her access to cash, turning off her computer after 6 pm, and not going to night clubs on her own.

The people Dr. Russell talked to were uniformly fanatic about maintaining their sleep. When disruptions to their routines did happen, these individuals did not hesitate to take a sleep medication. Adjusting meds doses was par for the course, but meds changes were seen as minor compared to the life and lifestyle changes Susie and Jodie and the others were willing to make.

Common tools included yoga and other stress-busters, but Dr. Russell was quick to note that some found these practices boring. Basically, we are all unique and need to come up with our means of coping. The people in Dr. Russell’s study were smart enough to do just that.

Hypomania Part VII: We Are Not Helpless Bystanders


by John McManamy
Thursday, April 13th, 2006
Last year I received a request from a publisher to write a blurb for an upcoming book entitled, “The Bipolar Workbook: Tools for Controlling Your Mood Swings.” I’m fairly skeptical of workbooks, but I had heard the author Monica Basco PhD of the University of Texas Southwestern Medical Center at Dallas speak at a conference several years back.

“I do not believe you should be a passive recipient of care,” she told me at that conference. So I gave the publisher the go-ahead to send me a manuscript copy of the book.

“The era of take your meds and shut up is over,” I wrote after reading the manuscript. Naturally, I didn’t expect the publisher to use my remarks, but there I was six months later on the back cover, featured as the top blurb. “Yes, we need our meds,” I went on to say, “but we also require the personal skills to be smart and vigilant about our illness.”

Dr. Basco is a leading proponent of cognitive behavioral therapy. The therapy is used extensively for treating depression, and is starting to come into its own to catch swings into hypomania and mania. The first section of “The Bipolar Workbook” sets the tone: “See It Coming,” says the heading. Emotions such as sadness or euphoria, Dr. Basco says, change the type of things you think about, as well as the quality of your thinking, which affects behavior.

Her book covers all aspects of bipolar disorder, but what she has to say about nipping baby manias in the bud is particularly apropos. For instance, the euphoria of a brewing mania can bring on the perception of a bright idea and the impetus to take on a new enterprise. This may lead one to stay up all night working on the idea, which sets us up for arriving at our day job exhausted and with racing thoughts. The bullet train to our next serious episode is about to leave the station.

“The problem was not the project,” Dr. Basco writes. “The problem was the timing … Emotions can set you up to overreact to internal or external events.”

”Walk away from the situation,” Dr. Basco advises. Take time to evaluate it. Sleep on it, get the advice of your friends. Count to ten.

Self-knowledge is the key. Most of us have learned the hard way. We don’t want to go there again. From our bitter experience we can take stock, spot patterns, recognize triggers. Dr. Basco uses various terms, but what she is driving at is mindfulness, the ability to recognize when the brain is starting to play tricks on us. We may personalize, catastrophize, engage in mind-reading and fortune-telling, think in absolutes, and on and on.

Catch the distortions in thinking as they occur, Dr. Basco advises, Control them by keeping them from influencing your behavior. Correct any errors in your logic.

Cognitive behavioral therapy is manual-based (no idle chit-chat), time limited (10 or 12 sessions max), and focuses on the here and now (you can’t change what happened in your childhood).

Because the therapy delivers results, it gets a strong thumbs-up from those in my support group who have tried it. Your medical plan may pick up the tab, but the short-term aspect of the therapy means you can contain your costs if you’re forced to foot the bill.

from psych central BP site
 

Some basics thing s that you can do starting today:

First, get eight hours of sleep, at night, every night. You have to keep your body rhythyms regular, and here's the place to start. Second, get thirty minutes of exercise every day. If you can get outside in the sun that's the best. Even if you just walk down to the corner and back a few times, it's critical that you do this. Good nutrition is also important...moderation in everything is the key. Are you in therapy? You will double your chances of recovery with both drug therapy and talk therapy. Also, find a support group in your area...go to www.DBSAlliance.org or www.nami.org to find a group in your area.

long as well...!
 

Bipolar 2
Bipolar II



Bipolar disorder, also sometimes called manic-depressive disorder, is a mood disorder in which a person experiences episodes of mania without other etilogies to rule out the diagnosis of bipolar disorder. Also, possible, and more commonly known, is to have extreme shifts in mood between depression and manic euphoria.

These "cycles" which vary in speed, can sometimes affect the victim's levels of motivation, energy, and functioning, can be disabling. The DSM lists two main types of bipolar disorder (recognized clinically as Bipolar I and Bipolar II), the former of which features more marked mania, along with possible diagnoses of a "single non-recurring manic episode" which may not be called "bipolar disorder".



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Treatment of disabling bipolar disorder is with mood stabilizers, prominently lithium salts or some anticonvulsants.

Epidemiology
In most populations, bipolar disorder affects around 1% of the population. Bipolar disorder is gender-neutral, affecting both women and men equally. According to psychiatrists, the first episode typically appears in adolescence or early adulthood (mean of 21 years of age) and if recurring or cycling, affects sufferers throughout their life span. Although traditionally thought of as an adult disorder, there is now recognition that children may also suffer from chronic bipolar disorder. (see Bibliography for references.)



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Etiology
A diagnosis of bipolar disorder means the diagnosis of a person having a spontaneous and usually first episode, and they hypothesize that is likely to reoccur with manic or hypomanic symptoms or if diagnosed while manic, depressive symptoms. The causes of a manic episode may also be determinable, leaving the diagnosis of chronic bipolar disorder in doubt. See manic episode or depressive episode.

Episodes linked to stressful events
Scientists assert that recurring (as opposed to singular non-recurring) bipolar disorder may be caused by a combination of biological and psychological factors. Most commonly the onset of this disorder can be linked to stressful life events. According to the "Kindling theory" and possibly assumed, periods of depression, mania, or "mixed" states of manic (euphoric) and depressive symptoms typically recur and may become more frequent, often disrupting work, school, family, and social life. It is possible to see single occurences of depression and mania which do not recur.

The "kindling" theory suggests that persons who are genetically prone toward bipolar disorder experience a series of stressful events, each of which lowers the threshold at which mood changes occur. Then at some point these mood changes occur spontaneously. The person then "becomes bipolar". This might explain why the cause of bipolar disorder is difficult to pinpoint but is somehow related to genetic and/or genetic and enviromental causes. People can also be "prone" to bipolar disorder after substance abuse, or because of a neurological condition or brain damage.

The Kindling Theroy has not been disputed. (as far as we are aware)

Multiple co-occuring explanations
If drug abuse can be linked to bipolar symptoms, they may not recur. Adderall and other drugs and amphetamines (including meth) have been cited as producing mania, even if the drug is not in the bloodstream. For such a patient, the euphoria of the Adderall might not wear off as quickly as it may for others. They may exhibit manic symptoms while on the drug. Some medications have depression as a side effect.

For some people, multiple factors may be valid, including:

stressful events or major life transitions
a family history of psychiatric diagnoses including bipolar disorder, clinical depression, or schizophrenia (This increases a family member's likelihood of having psychiatric symptoms by 10%)
past or present drug use (may complicate diagnoses if present and may lead to misdiagnoses)
Co-occurring conditions
The NIMH states that anxiety disorders and/or obsessive compulsive disorder (mild or severe) may co-occur with or after an episode. Such disorders are not episodic, so they may persist even when one's mood is stable. They may not respond to the medicine(s) that the bipolar disorder does. If thoughts of self-harm exist, the possibility of anxiety-linked obsessive-compulsive disorder should be explored.

Links with creativity
Many artists, musicians, and writers have experienced its mood swings, and some credit the condition with their creativity. However, this disease ruins many lives, and it is associated with a greatly increased risk of suicide. Kay Jamison, who herself is living with bipolar disorder and is considered the leading US expert on the disease, has also written several books that explore this idea. Research indicates that while manic phases may contribute to creativity (see Andreasen, 1988), hypomanic phases, such as those experienced in cyclothymia, actually contribute more (see Richards, 1988). This is perhaps due to the distress and impairment associated with full-blown mania.

Additionally, creativity has been linked to almost every medical conditions affecting the brain, including physical and cognitive disabilities.

Manifestations of bipolar disorder: types of episodes
Bipolar disorder manifests itself in numerous ways, most notably:

Depression: symptoms include a persistent sad mood; loss of interest or pleasure in activities that were once enjoyed; significant changes in body weight; significant changes in appetite; difficulty sleeping or oversleeping; physical slowing or agitation; loss of energy; feelings of worthlessness or inappropriate guilt; difficulty thinking or concentrating; recurrent thoughts of self-harm, death or suicide. (Some people are also diagnosed and treated for obsessive compulsive disorder, anxiety, and/or panic disorder.)
Mania: Abnormally and persistently elevated (high) mood and/or irritability accompanied by at least three of the following symptoms (four if the mood is merely irritable): decreased need for sleep; increased talkativeness; racing thoughts; distractibility; increased goal-directed activity such as shopping, or other tasks carried on in an urgent manner; physical agitation; hypersexuality; excessive involvement in risky activities. The behavior may seem unusual to friends or family, while the person's level of insight may vary, and is higher among those with co-occuring conditions.
Mania is often divided diagnostically into two categories:

full-blown manic episodes, and
hypomania, a less severe form of mania.
Hypomania is often not especially problematic for the person, as he or she typically feels very energetic and in a very good mood. As such, hypomania is often unreported and undiagnosed (this is perhaps the biggest cause of incorrect diagnoses between unipolar and bipolar depression.) Some patients experience only hypomania; in others, hypomania progresses into a full manic state in which the patient has more and more trouble retaining control, and the symptoms become more problematic. For some people, hypomania is an acceptable baseline.

Hypomania and mania can both make a person angry, making the mood shift harder to detect as even government guidelines advise that you watch for euphoria. Some people with bipolar disorder will never have full-blown mania; while others will have it rarely.

Mixed state: Symptoms of mania and depression are present at the same time. The symptom picture frequently includes agitation, trouble sleeping, significant change in appetite, psychosis, and negative thinking, some of which may be automatic (see Automatic Negative Thoughts (ANTs) leading to depression. In a mixed state, depressed mood accompanies manic "activation". Also known as dysphoric mania (from Greek dysphoria: dys, difficulty, phorós, bearer); it does not euphoric characteristics. This is the form most often seen in children.
Diagnostic criteria
According to the DSM-IV-TR (p. 345), the two principal forms of Bipolar disorder are:

Bipolar I disorder, the diagnosis of which requires over the entire course of the individual's life at least one manic (or mixed) state episode which is usually (though not always) accompanied by major depressive episodes.
Bipolar II disorder, which over the course of the individual's life must involve at least one major Depressive episode and must be accompanied by at least one hypomanic episode. There must be no manic episodes. If there were manic episodes, the accurate diagnosis would be Bipolar I.
Therefore, bipolar disorder need not have both severe manic episodes and depressive episodes. In certain cases the sufferer has only episodes of mania. There need be no "cycles" of mania and depression.

This is why certain contemporary psychiatrists avoid from the original name, "manic depression", which suggests that all individuals have both mania and depression. It is unrelated with the notion of equal distribution of cycles of mania and depression, since there need not be any cycles at all-in fact, even when there is one (or more) bout of both mania and depression over the course of an individual's life, the two episodes may be so unrelated to each other temporally and otherwise that this need not constitute a cycle. However, a significant portion of individuals with bipolar experience the classical alternating episodes (cycles) of mania and depression and therefore it is overstating the case to say that the classical alternation "rarely" occurs.

The DSM-IV treats these bipolar disorders as variants of mood disorders (or affective disorders). Other types include major depressive disorder and dysthymic disorder. Bipolar and other mood disorders may have no identifiable medical, traumatic or other external cause (exogenous) or may be due to a medical condition (endogenous). Current psychiatric view no longer labels mood episodes as endogenous or exogenous. The exceptions being a substance induced mood disorder or a mood disorder due to a general medical condition.

In order for a person to be properly diagnosed with bipolar disorders, the mood episodes cannot be due to external medication, drugs or treatment for depression.

Cycles in bipolar disorder
Emil Kraepelin, who first described the illness, included in his original description of manic depression the phenomenon that episodes of acute illness, whether mania or depression, are usually punctuated by relatively symptom-free intervals during which the patient is able to function normally both at work and in social affairs.

The cycles of bipolar disorder may be long or short, and the ups and downs may be of different magnitudes: for instance, a person suffering from bipolar disorder may suffer a protracted mild depression followed by a shorter and intense mania. The manic episodes typically include euphoria, tirelessness, and impulsivity particularly relating to activities; the depressed periods may seem much worse following a manic period from the point of view of the patient.

Severe depression or mania may be accompanied by symptoms of psychosis. These symptoms include hallucinations (hearing, seeing, or otherwise sensing the presence of stimuli that are not there) and delusions (false personal beliefs that are not subject to reason or contradictory evidence and are not explained by a person's cultural concepts). Psychotic symptoms associated with bipolar disorder typically reflect the extreme mood state at the time.

Domains of bipolar disorder
Mania
Researchers at Duke University have refined Kraepelin-s four classes of mania to include hypomania (featuring mainly euphoria), severe mania (including euphoria, grandiosity, sexual drive, irritability, volatility, psychosis, paranoia, and aggression), extreme mania (most of the displeasures, hardly any of the pleasures), and two forms of mixed mania (where depressive and manic symptoms collide)[2].

Hypomania
Hypomania is not necessarily a pathology, especially if not part of a cycle of mania or depression. Patients rarely, if ever, seek out a psychiatrist complaining of hypomania. Johns Hopkins psychologist John Gartner in The Hypomanic Edge contends that many of America-s greatest visionaries - including Christopher Columbus, Alexander Hamilton, Andrew Carnegie, Louis B Mayer, and Craig Venter (who mapped the human genome) owed their brilliance and drive (and eccentricities) to their hypomanic temperaments.

"Mania lite", however does carry a downside. Trisha Suppes of the University of Texas, Dallas points out that many hypomanic patients have symptoms of irritability (classic -road rage- cases). The DSM, at present, fails to recognize this fact of life. Hypomania can also signal the beginning of a more severe manic episode.

Unfortunately, hypomania has not been well-researched, and much more work needs to be accomplished before psychiatrists can accurately diagnose and treat this overlooked aspect of bipolar disorder. (See Hypomanic Nation.)

Bipolar depression
People with bipolar disorder are depressed far more often than they are manic. According to the Stanley Foundation Bipolar Network, bipolar patients spend three times more days in depression than they do in mania. For bipolar II patients, a study by Hagop Akiskal of the University of California, San Diego revealed this population was depressed 37 times more than they were hypomanic.

A 2003 study by Robert Hirschfeld of the University of Texas, Galveston found bipolar patients fared worse in their depressions than unipolar patients. (See Bipolar Depression.)

Cognition
Numerous studies show that bipolar disorder affects a patient's ability to think and perform mental tasks, even in states of remission. Deborah Yurgelun-Todd of McLean Hospital in Belmont, Massachusetts has argued these deficits should be included as a core feature of bipolar disorder.

By the same token, research by Kay Jamison of Johns Hopkins University and others have attributed high rates of creativity and productivity to individuals with bipolar disorder. (See Brain Damage.)

The Mood Spectrum
Clinical depression and bipolar disorder are classified as separate illnesses, but psychiatry is increasingly viewing them as part of an overlapping spectrum that also includes anxiety and psychosis.

In a 2003 study, Akiskal and Judd re-examined data from the landmark Epidemiological Catchment Area study from two decades before. The original study found that .08 percent of the population surveyed had experienced a lifetime manic episode (the diagnostic threshold for bipolar I) and .05 a hypomanic episode (the diagnostic threshold for bipolar II). But by tabulating survey responses to include criteria below the diagnostic radar, such as one or two symptoms over a short time period, the authors of the study recalculated the data to arrive at an additional 5.1 percent of the population, adding up to a total of 6.4 percent of the entire population who could conceivably be thought of as having bipolar disorder.

There is also a case that clinical (unipolar) depression can be bipolar disorder waiting to happen. In a 2005 study, Jules Angst and his colleagues at Zurich University tracked 406 patients with major mood disorders over a 20-year period. Of 309 patients presenting with depression, 121 (39.2 percent) eventually manifested as bipolar (24.3 percent to bipolar I, 14.9 percent to bipolar II). In all, more than 50 percent of the study population turned out to have bipolar disorder. (See The Mood Spectrum.)

Environmental factors affecting mood in bipolar disorder
In mid-2003, a twin study was published concerning environmental factors and bipolar disorder. The bipolar twin was found to be far more affected by changes in sunlight. Longer nights resulted in mood and sleep-length changes far greater than the healthy twin. Sunny days also did more to improve mood. In fact, natural light in general was found to have a profound positive effect upon the well-being of the bipolar twin.

Paradoxically, in the 2004 publication of a study using Tel Aviv's public psychiatric hospitals, it was found that "Admission rates of bipolar depressed patients increase during spring/summer and correlate with maximal environmental temperature". Unipolar depressed patient admission had no such correlation. High temperature points in the month, as well as high temperature months, were found to be correlated with depressive episodes in admissions.

Bipolar disorder and childbirth
For many women with depression or bipolar disorder, the postpartum period is a period of risk for developing illness. Episodes of bipolar disorder that follow childbirth are traditionally called postpartum depression (PD) puerperal psychosis (PP). Ian Jones of the Department of Psychological Medicine in Cardiff is researching this area.

Dual diagnosis
Bipolar disorder is often complicated by co-occurring alcohol or substance abuse. Traditionally this has been viewed as an attempt by patients to self-medicate the condition. More recently, some have doubted if this is an entirely accurate description. Cannabis in particular can alleviate symptoms of depression and may also have a mood stabilizing component in bipolar disorders, but the random titration of drug abusers usually does do more harm than good. There is growing evidence, however, that carefully titrated dosage of delta-9-THC tincture, taken sublingually, may prove of some benefit when taken with other mood stabilizer medications. In some cases, the substance abuse seems to begin before the onset of bipolar disorder, which is difficult to reconcile with the idea of self-medication (at least initially). Nicotine addiction is very common in people with bipolar disorder, and in the view of some, may be an active precursor to mature onset of both bipolar affective disorder and other forms of clinical depression in general.

Drugs like adderall, Ritalin or any stimulant can produce mania, but often times this is not actually bipolar disorder, but a singular manic episode. This is valid according to the DSM.

Treatment of bipolar disorder
There is no cure for bipolar disorder; the emphasis is on management of the symptoms. A variety of medications are used to treat bipolar disorder; many people with bipolar disorder require multiple medications (sometimes up to five). Some people with bipolar disorder add to or replace their Western medication with herbal or holistic options. Still, even with optimal medication treatment, many people with the illness have some residual symptoms. Cognitive therapy may work to lessen the severity of mood swings by recognizing and managing triggering symptoms or events.

Principles
Medications called mood stabilizers are be used to prevent or mitigate manic or depressive episodes. Because mood stabilizers are generally more effective at treating mania than bipolar depression, periods of depression are sometimes also treated with antidepressants, although this carries a risk of inducing mania (especially when no mood stabilizer is also prescribed).

In severe cases where the mania or the depression is severe enough to cause psychosis (and recently sometimes in less severe cases as well, although this remains controversial), antipsychotic drugs may also be used. A new class of atypical antipsychotics are also popular. The FDA has only approved them for acute episodes, if at all. Like most doctors, psychiatrists use medication for "off-label" uses, though this carries more risk of unexpected side effects.

Some people have reported that antipsychotics cause mania, panic attacks, or psychosis. Any agitation should be reported to the doctor immediately.

Medications work differently in each person, and it takes considerable time to determine in any particular case whether a given drug is effective at all, since bipolar disorder is sometimes episodic, and patients may experience remissions and periods of normal functioning (which may last years) whether or not they receive treatment. For this reason, neither patients nor their doctors should expect immediate relief, although extreme mania will seem to dissapate quickly. Dr. John Burrows says that patients should not expect full stabilization for at least 3-4 weeks.

Compliance with medications can be a major problem, because some people becoming manic lose insight, or the awareness of having an illness, and they therefore discontinue medications. They may suddenly find themselves initiating multiple projects often being scattered and ineffective, or may go on a spending spree or take a poorly planned trip landing them in an unfamiliar location without cash. The manic periods, euphoric as they may be, may seem or be disastrous because of the impulsiveness and irrationality that comes with them.

Depression does not respond instantaneously to resumed medication, typically taking 2-6 weeks to respond. Mania may disappear slowly, or it may become depression. Other reasons cited by individuals for discontinuing medication are side effects, expense, and the stigma of having a psychiatric disorder. In a relatively small number of cases stipulated by law (varying by locality but typically, according to the law, only when a patient poses a threat to himself or others), patients who do not agree with their psychiatric diagnosis and treatment can legally be required to have treatment without their consent. Throughout North America and the United Kingdom, involuntary treatment or detention laws exist for severe cases of bipolar disorder and other mental illnesses. In some cases, the burden of proof favors the psychiatrist.

Prognosis
While bipolar disorder can be one of the most severe and devastating medical conditions, fortunately many individuals with bipolar disorder can also live full and mostly happy lives with correct management of their condition. Compared to patients with schizophrenia, persons with bipolar disorder are more likely to have periods of normal functioning in the absence of medication. Although schizophrenic patients may have remissions with relatively high levels of functioning, schizophrenic patients tend to suffer some impairment during these intervals in contrast to persons with bipolar disorder who often appear completely healthy when they are between mood swings.

Lithium salts
The use of lithium salts as a treatment of bipolar disorder was first discovered by Dr. John Cade.

Lithium salts have long been used as a first-line treatment for bipolar disorder. In ancient times, doctors would send their mentally ill patients to drink from "alkali springs" as a treatment. They did not know it, but they were really prescribing lithium, which was present in high concentration in the waters. The therapeutic effect of lithium salts appears to be entirely due to the lithium ion, Li. The two lithium salts used for bipolar therapy are lithium carbonate (mostly) and lithium citrate (sometimes). Approved for the treatment of acute mania in 1970 by the FDA, lithium has been an effective mood-stabilizing medication for many people with bipolar disorder. Lithium is also noted for reducing the risk of suicide. Although lithium is among the most effective mood stabilizers, most persons taking it experience side effects similar to the effects of ingesting too much table salt, such as high blood pressure, water retention, and constipation. Regular blood testing is required when taking lithium to determine the correct lithium levels since the therapeutic dose is close to the toxic dose.

The mechanism of lithium salt treatment is believed to work as follows: some symptoms of bipolar disorder appear to be caused by the enzyme inositol monophosphatase (IMPase), an enzyme that splits inositol monophosphate into free inositol and phosphate. It is involved in signal transduction and is believed to create an imbalance in neurotransmitters in bipolar patients. The lithium ion is believed to produce a mood stabilizing effect by inhibiting IMPase by substituting for one of two magnesium ions in IMPase's active site, slowing down this enzyme.

Lithium orotate is used as an alternative treatment to lithium carbonate by some sufferers of bipolar disorder, mainly because it is available without a doctor's prescription. It is sometimes sold as "organic lithium" by nutritionists, as well as under a wide variety of brand names. There seems to be little evidence for its use in clinical treatment in preference to lithium carbonate. Self-treatment without medical monitoring is potentially dangerous.

Anticonvulsant mood stabilizers
Anticonvulsant medications, particularly valproate and carbamazepine, have been used as alternatives or adjuncts to lithium in many cases. Valproate (Depakote and Depakene) was FDA approved for the treatment of acute mania in 1995, and is now considered by many to be the first line of therapy for bipolar disorder. It is preferable to lithium because its side effect profile seems to be less severe, compliance with the medication is better, and fewer breakthrough manic episodes occur. However, valproate is not as effective as lithium in preventing or managing depressive episodes, so patients taking valproate may also need an SSRI or other antidepressant as an adjunct medicinal therapy. Some research suggests that different combinations of lithium and anticonvulsants may be helpful. Newer anticonvulsant medications, including lamotrigine, gabapentin, and topiramate, have been studied to determine their efficacy as mood stabilizers in bipolar disorder. Lamotrigine is particularly promising, as there is evidence it acts as a mood stabilizer and particularly helps bipolar persons with severe depression. Topiramate has not done well in clinical trials, which may be because it seems to help a few patients very much but most not at all. Unfortunately, there are several controlled studies that show that gabapentin is very effective for certain types of epilepsy and has a mild side effect profile but is ineffective for bipolar disorder. Nevertheless, many psychiatrists continue to prescribe topiramate and gabapentin for bipolar disorder, although this is becoming increasingly controversial.

According to studies conducted in Finland in patients with epilepsy, valproate may increase testosterone levels in teenage girls and produce polycystic ovary syndrome in women who began taking the medication before age 20. Increased testosterone can lead to polycystic ovary syndrome with irregular or absent menses, obesity, and abnormal growth of hair. Therefore, young female patients taking valproate should be monitored carefully by a physician. It should be noted, however, that the therapeutic dose for a patient taking valproate for epilepsy is very different than the therapeutic dose of valproate for an individual with bipolar disorder.

Atypical antipsychotic drugs
The newer atypical antipsychotic drugs such as risperidone, quetiapine, and olanzapine are often used in acutely manic patients, because these medications have a rapid onset of psychomotor inhibition, which may be lifesaving in the case of a violent or psychotic patient. Parenteral and orally disintegrating (in particular, Zyprexa Zydis) forms are favoured in emergency room settings. [7] These drugs can also be used as adjunctives to lithium or anticonvulsants in refractory bipolar disorder and in prevention of mania recurrence. In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder.[8] A head-to-head randomized control trial in 2005 has also shown olanzapine monotherapy to be just as effective and safe as Lithium in prophylaxis.[9]

Marijuana
Although the use of marijuana for the treatment of bipolar disorder is seldom mentioned by proponents of medical marijuana, there is anecdotal evidence that its use can alleviate the mood swings associated with the disease. The euphoriant effect of marijuana may be useful for mood elevation during the depressive phase, while the manic phase may be moderated by the tranquilizing effects of the drug.

Omega-3 fatty acids
Omega-3 fatty acids are also used as an alternative or additional treatment for bipolar disorder. Omega-3 fatty acids are polyunsaturated fatty acids which can be found in wild salmon, flaxseed and walnuts. To receive a significant dose, however, omega-3 fatty acids must usually be taken in the form of a fish oil supplement. An initial clinical trial by Stoll et. al. which produced strongly positive results . It has been hypothesized that the therapeutic ingredient in omega-3 fatty acid preparations is eicosapentaenoic acid (EPA) and that supplements should be high in this compound to be beneficial.

However, although there are a number of clinical trials with encouraging results, and widespread anecdotal reports of efficacy, attempts to confirm the hypothesized beneficial effects of omega-3 fatty acids in several larger double-blind clinical trials have so far produced unconclusive results.

Psychotherapy
Certain types of psychotherapy or psychosocial interventions, generally used in combination with medication, often can provide tremendous additional benefit. These include cognitive-behavioral therapy, interpersonal and social rhythm therapy, family systems therapy, and psychoeducation.

Electroconvulsive therapy
Electroconvulsive therapy (ECT) is sometimes used to treat severe bipolar depression in cases where other treatments have failed. Although it has proved to be a highly effective treatment, doctors are reluctant to use it except as a treatment of last resort because of the side-effects and possible complications of ECT, particularly when repeated treatments ("maintenance ECT") are needed.

Alternative treatments
Complementary non-Western treatments, such as acupuncture and orthomolecular therapy, are used by people with bipolar disorder, and some research shows that some of them may have some scientific merit.

Treatment issues
Nearly all bipolar treatment studies have involved treating patients in the acute (initial) mania stage, where overmedication is often justified in removing a patient from danger. Much less is known, however, about long-term treatment, where relapse prevention and full remission are the main treatment goals.

Virtually nothing is known about treating hypomania. Conceivably patients in hypomania, if otherwise stable, could be treated with reduced medication doses, various forms of talking therapy, or relaxation exercises, but there are no studies to guide patients and psychiatrists. On one hand, mild hypomania may be a legitimate baseline for some patients. For others, hypomania may signal the beginning of a cycle into more severe mania, necessitating immediate intervention.

Until recently, depression was largely overlooked in bipolar disorder. The anticonvulsant medication, lamotrigine is often used for treating bipolar depression, particularly where other drugs have failed and the patient's disorder has a strong depressive component. New clinical trials are finding that certain new-generation antipsychotics such as olanzapine and quetiapine show some beneficial effect in treating bipolar depression. Lithium also has a mild antidepressant effect.

Because there is a danger of antidepressant medications such as SSRIs switching bipolar patients into mania, these medications are used with caution, nearly always with an antimania agent[12].

Research findings
Heritability
Bipolar disorder appears to run in families. The rate of suicide is higher in people who have bipolar disorder than in the general population. In fact, people with bipolar disorder are about twice as likely to commit suicide as those suffering from major depression (12% to 6%).

The rate of prevalence of bipolar disorder is roughly equal in men and women. Lifetime risk of bipolar I disorder is often quoted as around 1%, but when bipolar II is included the true rate may be around 4%.

More than two-thirds of people with bipolar disorder have at least one close relative with the disorder or with unipolar major depression, indicating that the disease has a heritable component. Studies seeking to identify the genetic basis of bipolar disorder indicate that susceptibility stems from multiple genes. Scientists are continuing their search for these genes using advanced genetic analytic methods and large samples of families affected by the illness. The researchers are hopeful that identification of susceptibility genes for bipolar disorder, and the brain proteins they code for, will make it possible to develop better treatments and preventive interventions targeted at the underlying illness process.

Recent genetic research
Bipolar disorder is considered to be a result of complex interactions between genes and environment. The monozygotic concordance rate for the disorder is 70%. This means that if a person has the disorder, an identical twin has a 70% likelihood of having the disorder as well. Dizygotic twins have a 23% concordance rate. Children of a bipolar parent have a 50% chance of developing schizophrenia, schizoaffective or bipolar disorder. First degree relatives are seven times more likely to develop the condition than the general population.

In 2003, a group of American and Canadian researchers published a paper that used gene linkage techniques to identify a mutation in the GRK3 gene as a possible cause of up to 10% of cases of bipolar disorder. This gene is associated with a kinase enzyme called G protein receptor kinase 3, which appears to be involved in dopamine metabolism, and may provide a possible target for new drugs for bipolar disorder.

Medical imaging
Researchers are using advanced brain imaging techniques to examine brain function and structure in people with bipolar disorder, particularly using the functional MRI. An important area of imaging research focuses on identifying and characterizing networks of interconnected nerve cells in the brain, interactions among which form the basis for normal and abnormal behaviors. Researchers hypothesize that abnormalities in the structure and/or function of certain brain circuits could underlie bipolar and other mood disorders. Better understanding of the neural circuits involved in regulating mood states may influence the development of new and better treatments, and may ultimately aid in diagnosis.

Personality types
An evolving literature exists concerning the nature of personality and temperament in bipolar disorder patients, compared to major depressive disorder (unipolar) patients and non-sufferers. Such differences may be diagnostically relevant. Using MBTI continuum scores, bipolar patients were significantly more extroverted, intuitive and perceiving, and less introverted, sensing, and judging than were unipolar patients. This suggests that there might be a correlation between the Jungian extraverted intuiting process and bipolar disorder.

Research into new treatments
In late 2003, researchers at McLean Hospital found tentative evidence of improvements in mood during EP-MRSI imaging, and attempts are being made to develop this into a form which can be evaluated as a possible treatment.

It has been hypothesized that bipolar disorder may be the result of poor membrane conduction in the brain and that one possible cause may be a deficiency in omega-3 fatty acids. Following an encouraging small-scale study conducted by Andrew Stoll at Harvard University's McLean Hospital, the Stanley Foundation is sponsoring research regarding the beneficial claims, and several large scale trials of treatment using omega-3 fatty acids are under way.

NIMH has initiated a large-scale study at twenty sites across the U.S. to determine the most effective treatment strategies for people with bipolar disorder. This study, the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), will follow patients and document their treatment outcome for 5 to 8 years. For more information, visit the Clinical Trials page of the NIMH Web site.

In 2005 two double blind placebo controlled studies were underway at Harvard University and University of Calgary to determine if the trends noted in several open label trials using a mineral, vitamin and amino acid supplement called E.M. Power would continue to demonstrate effectiveness. In preliminary studies, as many as 70% of patients taking the supplements were free of symptoms after slowly having withdrawn from psychotropic medications.

For immediate management of mania, left coloric vestibular stimulation has proven effective in dramatically and rapidly stopping mania for up to 24 hours. Currently there are only case reports, and there has been no organized research on use of the procedure for acute mania.

Another avenue for treatment that has, at times been curative for resolving manic psychosis is by treating an underlying infections such as Lyme disease. Results in these cases suggest that the term bipolar disorder may not accurately represent the actual biological disorders which meet the DSM-IV requirement for a bipolar disorder. For an unknown number of patients, the problem may be a kind of immune mediated disorder provoked by Lyme disease (Toxoplasmosis, Bornea virus), or any or a number of other chronic infections, including something as common as the flu.

Bipolar disorder, talent and famous people
Many famous people are believed to have been affected by bipolar disorder, based on evidence in their own writings and contemporaneous accounts by those who knew them. Bipolar disorder is found in disproportionate numbers in people with creative talent such as artists, musicians, authors, poets, and scientists, and it has been speculated that the mechanisms which cause the disorder may be related to those responsible for creativity in these persons. (Many of the historical creative talents commonly cited as bipolar were "diagnosed" retrospectively after their deaths and thus the diagnoses are unverifiable; however, in cases diagnosed in recent decades there does seem to be at least some correlation between bipolar disorder and creativity.) The possible explanation for this is that hypomanic phases of the illness allow for heightened concentration on activities and the manic phases allow for around-the-clock work with minimal need for sleep. See list of people believed to have been affected by bipolar disorder.

Sources
Material from public domain text copied from http:www.nimh.nih.gov/publicat/manic.cfm which states: "All material in this fact sheet is in the public domain and may be copied or reproduced without permission from the Institute. Citation of the source is appreciated."
1, 2, 3 and 4 Links and references showing that gabapentin (Neurontin) is an inappropriate and ineffective medication for bipolar disorder.
Suicide rate of persons with bipolar disorder
References
^ Link and reference involving kindling theory
^ Hakkarainen R, et al. (2003). Seasonal changes, sleep length and circadian preference among twins with bipolar disorder. BMC Psychiatry 3 (1), 6.
^ Shapira A, et al. (2004). Admission rates of bipolar depressed patients increase during spring/summer and correlate with maximal environmental temperature. Bipolar Disorder Feb;6 (1), 90-3.
^ Baldessarini RJ, et al. (2003). Lithium treatment and suicide risk in major affective disorders: update and new findings. J Clin Psychiatry 64 (Suppl 5), 44-52.
^ 1 and 2 Links and references showing the promise of lamotrigine (Lamictal) in the treatment of bipolar depression.
^ Osher Y, Bersudsky Y, Belmaker RH. Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study. J Clin Psychiatry. 2005;66(6):726-9. PMID 15960565
^ Stoll AL, Severus WE, Freeman MP et al. (1999), Omega 3 fatty acids in bipolar disorder. A preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 56(5):407-412.
^ Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593-602. PMID 15939837
^ Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR. Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Mol Psychiatry. 2003 May;8(5):546-57.
Further reading
Classic works on this subject include

Manic-depressive insanity and paranoia by Emil Kraepelin., 1921. ISBN 0405074417 (English translation of the original German from the earlier Eighth Edition of Kraepelin's textbook - now outdated, but a work of major historical importance).
Manic-Depressive Illness by Frederick K. Goodwin and Kay Redfield Jamison. ISBN 0195039343 (The standard, very lengthy, medical reference on bipolar disorder.)
Touched With Fire: Manic-Depressive Illness and the Artistic Temperament by Kay Redfield Jamison (The Free Press: Macmillian, Inc., New York, 1993) 1996 reprint: ISBN 068483183X
An Unquiet Mind: A Memoir of Moods and Madness by Kay Redfield Jamison (Knopf, New York, 1995) (An excellent autobiographical work about what it's like to have bipolar disorder, by the woman who is also one of the medical world's experts on it.) ISBN 0330346512
Mind Over Mood: Cognitive Treatment Therapy Manual for Clients by Christine Padesky, Dennis Greenberger. ISBN 0898621283
Bipolar Disorder: A guide for patients and families by Francis Mondimore M.D., 1999. ISBN 0801861179 (A detailed in-depth book covering all aspects of bipolar disorder: history, causes, treatments, etc.)

screening tool
 

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The HCL-32 is a screening tool for researchers trying to find people with bipolar disorder. This is one of the better "complete but simple" lists of manic-side symptoms. It's a good "fine-tooth comb" when people want to inventory all possible hypomanic symptoms, usually in the context of asking "do I really have bipolar disorder?" (Download pdf of symptom list only)
Remember, however, that this is not exactly the right question. As at the Harvard bipolar clinic, we should instead be asking "how much bipolarity might you have?" In that clinic's Bipolarity Index, you'll note that hypomania or mania only account for up to 1/5th of the possible score; the other 4/5th's of the total 100 points possible come from other factors such as family history, age of onset of depression, course of the depressions since, and response to medications.
Thus you should not look at the HCL as a "yes or no" tool for detecting bipolar disorder. It's simply a handy way to check what should be checked when looking for hypomania or mania -- which is just one part of the story. Okay, with that reminder, here we go.
At different times in their life everyone experiences changes or swings in energy, activity and mood ("highs and lows" or "ups and downs"). The aim of this questionnaire is to assess the characteristics of the "high" periods.
1. First of all, how are you feeling today compared to your usual state?

Much worse than usual Worse than usual A little worse than usual Neither better nor worse than usual
A little better than usual Better than usual Much better than usual

2. Compared to other people, my level of activity energy and mood: (Not how you feel today, but how you are on average)

is always rather stable and even is generally higher is generally lower repeatedly shows periods of ups and downs

3. Please try to remember a period when you were in a "high" state (while not using drugs or alcohol). In such a state:

1. I need less sleep
2. I feel more energetic and more active
3. I am more self-confident
4. I enjoy my work more
5. I am more sociable (make more phone calls, go out more)
6. I want to travel and/or do travel more
7. I tend to drive faster or take more risks when driving
8. I spend more money/too much money
9. I take more risks in my daily life (in my work and/or other activities)
10. I am physically more active (sport etc.)
11. I plan more activities or projects.
12. I have more ideas, I am more creative
13. I am less shy or inhibited
14. I wear more colourful and more extravagant clothes/make-up
15. I want to meet or actually do meet more people
16. I am more interested in sex, and/or have increased sexual desire
17. I am more flirtatious and/or am more sexually active
18. I talk more
19. I think faster
20. I make more jokes or puns when I am talking
21. I am more easily distracted
22. I engage in lots of new things
23. My thoughts jump from topic to topic
24. I do things more quickly and/or more easily
25. I am more impatient and/or get irritable more easily
26. I can be exhausting or irritating for others
27. I get into more quarrels
28. My mood is higher, more optimistic
29. I drink more coffee
30. I smoke more cigarettes
31. I drink more alcohol
32. I take more drugs (sedatives, anti-anxiety pills, stimulants)

The remaining questions ask how these "highs" affect your life (positively or negatively); other people's reactions to them; how long they last; whether you've had one recently; and how much of the last year has been spent in such a state.

If you are considering suicide...
From the American Association of Suicidology - http://www.suicidology.org/

Quote:
IF YOU ARE CONSIDERING SUICIDE

The last thing that most people expect is that they will run out of reasons to live. But if you are experiencing suicidal thoughts, you need to know that you’re not alone. By some estimates, as many as one in six people will become seriously suicidal at some point in their lives. Fortunately, most people do not act on their suicidal thoughts – crises pass and problems are solved. But sometimes thoughts lead to self-harm.

Some Important Facts AAS Would Like to Share with You

Suicidal thinking is usually associated with problems that can be treated. Clinical depression, anxiety disorders, chemical dependency, and other disorders produce profound emotional distress. They also interfere with effective problem-solving. But you need to know that new treatments are available, and studies show that the vast majority of people who receive appropriate treatment improve or recover completely. Even if you have received treatment before, you should know that different treatments work better for different people in different situations. Several tries are sometimes necessary before the right combination is found.

If you are unable to think of solutions other than suicide, it is not that solutions don’t exist, only that you are currently unable to see them. Therapists and counselors (and sometimes friends) can help you to see solutions that otherwise are not apparent to you.

Suicidal crises are almost always temporary. Although it might seem as if your unhappiness will never end, it is important to realize that crises are usually time-limited. Solutions are found, feelings change, unexpected positive events occur. Suicide is sometimes referred to as “a permanent solution to a temporary problem.” Don’t let suicide rob you of better times that will come you way when you allow more time to pass.

Problems are seldom as great as they appear at first glance. Job loss, financial problems, loss of important people in our lives – all such stressful events can seem catastrophic at the time they are happening. Then, month or years later, they usually look smaller and more manageable. Sometimes, imagining ourselves “five years down the road” can help us to see that a problem that currently seems catastrophic will pass and that we will survive.

Reasons for living can help sustain a person in pain. A famous psychologist once conducted a study of Nazi concentration camp survivors, and found that those who survived almost always reported strong beliefs about what was important in life. You, too, might be able to strengthen your connection with life if you consider what has sustained you through hard times in the past. Family ties, religion, love of art or nature, and dreams for the future are just a few of the many aspects of life that provide meaning and gratification, but which we can lose sight of due to emotional distress.

Do not keep suicidal thoughts to yourself! Help is available for you, whether through a friend, therapist, or member of the clergy. Find someone you trust and let them know how bad things are. This can be your first step on the road to healing.

Telephone Numbers for More Information on Receiving Help

National Mental Health Association 703-684-7722
Anxiety Disorders Association of America 301-231-9350
American Psychological Association 202-336-5500
American Psychiatric Association 202-682-6000
Depressive and Manic-Depressive Association 312-642-0049
National Alliance for the Mentally Ill 703-524-7600
National Suicide Prevention Lifeline 800-273-TALK
(800-273-8255)

Med mix up
 

:grouphug:
What a great article. I agree with most of it. I was diagnosed about 16 years ago bi-polar, took a few years to get the right meds, but my combo has worked so well over the past 14 years, that I have kept jobs, relationships, my kids talk to me, and I have a few great groups of supportive friends.
I am in a little bit of a bind today however. I sent my prescriptions to the mail in pharmacy (being the first of the year I have to meet an insurance deductable) so the 90 day scripts for the meds I take weren't covered and they wouldn't mail them without an approval from me. Well, they kept leaving messages on my home phone, which I don't check and never tried my cell...so by the time I recieved the Letter in the mail informing me they were holding onto my scripts until they were authorized, I was already out of my meds!
I was told I would recieve them by the end of the week ( I now have been off them for 4 days, that will make 9 days).
I called my dr's office, explaining to them what happened and that I was already feeling like an electric current was running through my normally serene body, they agreed to call in 4 days worth to the local pharmacy.
When I landed at the pharmacy..they refuse to fill it...saying I could go to jail for it.
I believe in peace, love and joy. Serenity, bliss and happiness, so no I didn't threaten, though I did try to reason wiht the pharmasist.
She still refused to give me 4 days worth. I did not pull the mental illness card (which could have been fun, but sadistic).
SO
After all that,,,,I am trying to find out what kind of withdrawl symptoms I can expect to experience until the "pills come in the mail".
I have been on Tegretol and Paxil for over 15 years.
Every day, working in New York and Hawaii, I had my pills...
this is the first time I have not been able to get them.
The electrical charge is strongest when I am sitting still... I am going to ask the Divine to assist me in this as I seem to be quite helpless tonight..
Any ideas?

I read it and I think it is very informative. Thanks to you I have an idea of what I am dealing with :) I have Bipolar disorder level 1. I am not on meds at all. But I seem to be doing pretty well. But my moods however is a different story.:p

Self-Defeating Beliefs and irrational thinking
1. Emotional perfectionism: " I should always feel happy, confident and in control of my emotions"

2. Emotophobia: "I should never feel angry, anxious, inadequate, jealous or vulnerable."

3. conflict phobia: " people who love each other should not fight"

4. entitlement: "people should be the way I expect them to be."

5. low frustration tolerance: "I should never feel frustrated,
life should be easy"

6. performance perfectionism: "I must never fail or make a mistake"

7. perceived perfectionism: "people will not love and accept me as
a flawed and vulnerable human being"

8. fear of failure: "my worthwhileness depends on my achivements,
(or my intelligence, or status or attractiveness)."

9. fear of disapproval or criticism: "I need everybody's approval to be
worthwhile"

10. fear of rejection or being alone: "If I am alone, then I'm bound to feel miserable and unfulfilled. If I am not loved life is not worth living."

These are self-defeating beliefs and might be part of our self esteem and
linked to co-dependant behavior.
Each one of these beliefs is irrational thinking and are some common cognitive distortions. They include the 10 types of stinkng thinking.

1. all or nothing thinking: "I am either a success or a failure" " the world is either black or white"

2. Mind reading: "They probably think that I am incompetent," "I just know that he or she disapproves" Don't jump to conclusions.

3. emotional reasoning: "Because I feel inadequate. I am inadequate"
"What I feel therefore I am."

4. Personalizations: "That comment wasn't just random, it must have been directed toward me."

5. Overgeneralization: "Everything I do turns out wrong. It doesn't matter what my choices are, I always fall flat."

6. Catastrophizing: "If If I go to the party there will be terrible consequences", " I better not try because I might fail and that would be awful!"

7. Should statements: "I should visit my family everytime they want me to." " You should do this or that"

8. Control Fallacies: "If I'm not in complete control all fo the time, I will go out of control" "I must be in control of all of the contingencies in my life."

9. Comparing: "I am not as competant as my co-workers or supervisors." "Compared to others there is clearly something flawed about me."

10. Heavens reward fallacy: "If I do everything perfectly here, then I will be rewarded later," I have to muddle through this life maybe things will be better latter."

11. Disqualifying the positive: "This success experience was only a fluke', "The compliment that I received was unwarrented"

12. Perfectionism: "I must do everything perfectly or I will be criticized and a failure."
"An adequate job is akin to a failure"

13. Selective abstraction: The rest of the information doesn't matter. This is a salient point" "I must focus on the negative details
while I ignore and filter out all of the positive aspects of a situation. and obcess about it"

14. Externalization of self worth: "my worth is dependant upon what others think of me" "They think therefore I am"

15. Fallacy of change: "You should change your behavior because I want you to."They sould act differently because I expect them to."

16. Fallacy of worrying: " If I worry enough it will be resolved." "One cannot be too concerned"

17. Fallacy of ignoring: "If you isnore it, maybe it will go away." If I don't pay attention then I will not be held responcible"

18. Fallacy of fairness: "Life should be fair, people should be fair."

19. Being right: I must prove that I am right because being wrong is unthinkable." To be wrong is to be a bad person."

20. Fallacy of attachment. "I can't live without a man." "If I was in an intimate relationship all of my problems will be solved." "You can only be attached by being intimate with them."

Self Defeating
 

Helpful, any other self defeating articles?

Diagnosed Bi-polar at 63
 

This overview "101" was exactly what I was looking for. Many thanks.
After being diagnosed as a typical only child at 8, depressed after my husband & child died, then clinically depressed while caring for my Alzheimer's-suffering dad (all of which were treated with lots of drugs but not, in my opinion, successfully), I was told that all that was wrong & that all my life I was dealing with a bi-polar condition. I've been treated with low doses of neurotin (had to stop because of side effects, speech probs) now topamax (milder side effect of skin prickling, mainly around mouth). The change this medication has had on my life has amazed me & leaves me convinced that I finally have a proper diagnosis.
I was already on cymbalta from my MD for statin pain, which the psychiatrist says will moderate the topamax & prevent my tipping over into mania. To my knowledge I've never had a manic episode. Do I now have to worry about this "mood stabilizer" becoming an upper? & is this the way these 2 drugs interact? My pharmacist says no.
Anyone who's been there, please advise.

hi jude,
have you noticed any mental fogging with the topamax?
there are other mood stabilizers if this is not working for you.
bizi
welcome to the forums.

Nope, no fogging that I've noticed. No feedback suggesting any.
Thanks so much for what you've posted. No wonder my psych recommended that I come here. Your welcome is also appreciated.

nice to meet you jude.
I am sorry for your losses. are you living alone now?
do you have family support?
I have a husband and no children and worry about my future.
bizi

Very nice to meet you, Bizi <envision me grinning broadly with joy>!
Yes, I've been alone for about 20 yrs now--though not really, because I have critters.
What was left of my family thought me odd & always tried to shift me off on the other side of the family, so I disowned them all. They were relieved, I was too, & now my "family" is one I've put together from a few very excellent friends. There are three of them, 2 younger than me who are my healthcare surrogates.
I worry about my future too. Probably everyone with a grain of sense does. Having kids (considering some of the kids I know) would not necessarily ease those fears. It's a very scary world.
I'm glad I found this website. You, Mari, wave, the others. I know it's going to help.

Weird bipolor
 

Hi everyone, just wanted to post on this bipolar thread and see if anyone has ever heard of a case such as mine.

I'm 56 now and I've had a major depression every 10 years since I was 25. Major where I couldn't sleep, lost significant weight and wanted to die (suicidal thoughts) for much of the depression. Hospitalization required.

The end of 2010 started another depression which lasted about 5-6 months. The doc subscribed remeron which he said would help me sleep and give me back my appetite. This worked, I gained all of my weight back but I also went into a significant (2.5 weeks) mania stage where I needed hospitalization.

They took me off of the remeron and put me on lithium and seroquel which definately leveled me out.

My question is, how uncommon is it to become bipolar at age 56, or have I been bipolar all along, just without major mania?????

I am really gleaning a lot from the board, thanks for those that contribute so much.

late onset is not typical, but not impossible.

were your prior depressions typical (melancholy mood, loss of interest in activities, low energy) or did you have agitated depressions (agitation, anxiety, irritable mood?)

also wondering if you were ever medicated for depression before this time?

if not, it is likely you had a manic reaction to the antidepressant Remeron, which can happen to bipolars and non-bipolars. but bipolars are more predisposed.

there is debate regarding whether a diagnosis of bipolar can be made based on a manic reaction to an antidepressant alone. the DSM clearly states that mania as a drug reaction cannot be considered, and that there must be manic or hypomanic episodes in the patient's history. however, some pdocs do, and some even give it a name (Bipolar III, where the DSM describes only bipolar I, II, and NOS).

perhaps when you were hospitalized, and they took your history, they were relatively able to establish or suspect prior periods of hypomania and went with Bipolar as being the "best-fitting" diagnosis for you at this point. this would also serve as a caution to new doctors who might otherwise feed you antidepressants and, possibly, make you manic again.

the deal with antidepressants is not all or nothing, either. just because one makes you manic doesn't mean another will. just keep track of your reactions, and let new doctors know. also slow titration is always prudent.

hope that helps

~ waves ~

Transformation is exhausting!
 

Well I wish there were a better way for them to figure out the drugs. Pdoc had my Cymbalta + Topamax perfectly suited. Life was grand day in & day out, I could adjust to cope. Then a depression hit, & nothing's worked since. He added Abilify. It made me feel At Attention & didn't help depression. Pdoc cut it out. Now I have to wait 2wks for it to leave my system bfr anything else--meantime original Cymbalta + Topamax aren't doing piddlysquat for me. I'm sad, mad, all the stuff I was a couple yrs ago! It's always like this whenever another drug needs to join the mix. & every time I wonder whether I'm gonna survive the transformation. Reminds me of all those weirwolf movies of the 1930s & 40s. Transforming is exhausting! Even for a theatre major...

Dear CarGirl,

Hold on. I hope you get better.

M

Yes. Holding on is the secret, isn't it. Thank you;).

http://psychcentral.com/blog/archive...hly-sensitive/
5 Gifts of Being Highly Sensitive
By Therese J. Borchard
Associate Editor

I was diagnosed with bipolar 2 three an a half years ago, after having my mother fight for the diagnosis for me from a young age. I have had classic symptoms since I was a preteen and have tried so may different meds it makes my head spin thinking about it. I am so glad to have stumbled upon this site and this forum. Thank you for your detailed posts! I have always had a hard time understanding my dx because it has never really been fully explained to me. Your posts have been helpful in helping me to understand this disorder, especially the one concerning hypomania! I cried reading some of this because I have struggled with episodes of moderate mania and sever depression since I was a kid. Im 28 years old now with 3 children, only one of whom lives with me, and it i STILL a daily struggle. This was such a help, and I don't feel so alone now! Thanks again! :)

Thank you
 

I was diagnosed as major depressive disorder about 25 years ago and knew then I was manic depressive. I have recently been diagnosed as bipolar. Unfortunately, my life is in a complete shambles. This information is very helpful to me. I think it just made me feel a tiny bit less like an alien. That is quite a feat! Thanks again. :)

Bizi

I have read your post several times. I wouldn't shorten it. It has a wealth of information. Any reference material (like your post) is useful many times over. So I'm glad that it is here and so informative. Thanks again for posting it.

As a young person who is just not only starting to realize, but full aware of how this disorder is affecting my life and has previously before learning what was affecting myself... This article YES LONG but for someone who is grabbing at straws right now trying to find an answers and methods/skills to cope with this. The article is almost a god send...

Now when i look back at all the times ive been challenged with "life" knowing this years ago would have helped...

My big question is, management skills and how to cope.. Currently "coping" is becoming harder each day the past couple weeks have just been a huge nightmare of crying and punching stuff(4 fractured fingers) and no sleep... My food intake is horrible, maybe 2000 calories a week...

Any help would be so appreciated

Hi,

Make an appointment with a psychiatrist.
Or see regular family doctor to make a recommendation / referral to a psychiatrist.
Or go to the ER.

The psychiatrist will evaluate you and perhaps give you some medication.

The coping skills are about dealing with the medications.


Mari

Currently seeing a medical team, and have been put on 900mg of lithium (been about a week and a half now)

Eburns,


Avoid or reduce coffee if you can.

Did the pdoc (psychiatrist) ask you to take the lithium in divided doses -- part of it in the morning and part later in the day for example?
Drink plenty of water.
Some times after two weeks some people start to feel a little bit better but it usually can take several weeks longer to feel the way you want.
Probably the pdoc wants you to get a blood test soon to see your blood level. Then you might be given a higher dose.


Here are some web sites that might be helpful.
http://www.nami.org/Content/ContentG...e1/Lithium.htm
http://www.crazymeds.us/pmwiki/Meds/Lithium
http://www.psycheducation.org/depres...s/lithium.html

NAMI is a good organization for family members: https://www.nami.org
They might have a good support group near you.
http://www.nami.org/Template.cfm?Sec...iateFinder.cfm

You can also find other bipolar groups in real life at http://www.meetup.com

Again, do not concern your self with skills at this time.
Is there something that you are most concerned about?
Try to get enough sleep at night, mostly eat things that are healthy for you, and get some exercise if you can -- like walking.
(If you exercise and sweat a lot, you will need to drink lots and lots of water -- Lithium is a salt.)

Take it easy on yourself while your body and brain are going through this med transition.


M