Parkinson's disease: return of an old prime suspect
Neuron. 2007 Jul 5;55(1):8-10. Links
Parkinson's disease: return of an old prime suspect.Sulzer D, Schmitz Y. Department of Neurology, Columbia University Medical School, New York State Psychiatric Institute, New York, NY 10032, USA. d...@columbia.edu Pacemaking activity in adult substantia nigra (SN) dopamine neurons relies on L-type Ca2+ channels, but a surprising study in Nature by Chan et al. demonstrates that blockade of these channels by dihydropyridines re-establishes the pacemaking driven by sodium and HCN channels found in juvenile SN. This shift protects SN neurons in chemical models of Parkinson's disease (PD), suggesting that elevated intracellular Ca2+ participates in SN cell loss and that dihydropyridines may provide therapy in PD. PMID: 17610813 [PubMed - indexed for MEDLINE] (dihydropyridines are calcium channel blocker agents used in cardiovascular diseases, including arrhythmias) |
Thanks Madeleine,
I have met Dr. Sulzer, Peg and I sat at dinner table with him and his wife in New York, gosh life sounds fabulous too bad i always feel like crap. He's an interesting personality and anything for now would be good. paula oh dear I typed this and then decided to at last read Birtes piece. Thanks to her too -I sure needed something solid to read! paula |
Again the electrolytes
Went searching for a "natural" dihydropyridine as is my wont. Seems that another old friend fills the bill - magnesium.
"... Although Mg2+ is three to five orders of magnitude less potent than the organic Ca2+ channel blockers, it possesses unique and potentially useful Ca2+ antagonistic properties. PMID: 3300911 [PubMed - indexed for MEDLINE]" So, to recap: 1) Steffi works wonders with her "Metatone" tonic (an electrolyte megamix). 2) I find that potassium (another electrolyte) really is important. 3) And now we have hints that the interaction between two other electrolytes - calcium and magnesium - may be more relevant than supposed. Anyone know much more on this one? -Rick |
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