High Cholesterol Can Increase Risk of Parkinson's Disease
 

Anybody else heard of this link to PD?


High Cholesterol Can Increase Risk of Parkinson's Disease
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February 30, 2030 by Camilla Hodge

There has been much debate about the role of cholesterol in developing Parkinson's disease. A new study indicates that high cholesterol can affect people ages 24 to 54 and increase their risk of Parkinson's disease. High cholesterol is a significant medical concern for other reasons as well. Read more about the implications of this study.

There is more to this article if anyones interested.
Dan

cholesterol and PD
 

note that the findings were in age range 24-54 --young onset PD. Not for ages >54, which accounts for sporadic onset PD, the greatest % of all PD cases. Dr. Xuemei Huang, MD, found low LDL levels had a positive correlation with PD. She has designed a clinical study to determine if statin use is associated with the onset of PD; she has not found funding to date.

the mavelonate pathway is blocked by statin drugs; one of the sort of "incidental" findings is that statins interrupt the pathway to production of "dolichols". The substantia nigra is composed mainly of fats; the largest % of fats making up the SN are dolichols. Does it matter clinically if one blocks the pathway that accounts for the largest composition of the Substantia nigra structure? Who knows? Who would ever fund this study?
and that is just one of the pathways blocked by statins, there are many others which accomplish essential biological functions.

In some reports, statins are found to cause muscle aches in a large % of patients. madelyn

the jury is very much out
 

I, too, wonder about the age jump. I wonder, too, if any "statin" money was in the funding. I suspect the whole cholesterol frenzy. As was just pointed out, you need cholesterol for nerve health. Another function of cholesterol is to bind and safely transport for detox the bacterial toxin LPS which seems at the core of neuroinflammatory aspects of PD.