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-   -   Scientists: century-old drug might cure Parkinson’s, more (https://www.neurotalk.org/parkinson-s-disease/52430-scientists-century-drug-cure-parkinson.html)

dbiker2 08-19-2008 02:44 AM

Scientists: century-old drug might cure Parkinson’s, more
 
Has anyone seen or heard of this???

http://www.world-science.net/othernews/080818_blue

jeanb 08-19-2008 07:13 AM

read it
 
I read this - couldn't find a lot more info on it tho....

Quote:

Originally Posted by dbiker2 (Post 349890)
Has anyone seen or heard of this???

http://www.world-science.net/othernews/080818_blue


olsen 08-19-2008 09:40 AM

methylene blue info from wikipedia
 
http://en.wikipedia.org/wiki/Methylene_blue

"...Methylene blue is a monoamine oxidase inhibitor,[4] and if infused intravenously at doses exceeding 5 mg/kg, may precipitate serious serotonin toxicity, serotonin syndrome, if combined with any selective serotonin reuptake inhibitors (SSRIs) or other serotonin reuptake inhibitor (e.g., duloxetine, sibutramine, venlafaxine, clomipramine, imipramine).[5]

TauRx Therapeutics has reported that methylene blue (methylthioninium chloride), under the tradename rember, may provide a way of halting or slowing the progression of Alzheimer's dementia.[6] However, the formulation used was different from that commonly available as a medicine and caution has been expressed about use of methylene blue as a treatment for Alzheimer's.[7] TauRx Therapeutics has suggested that the mechanism by which methylene blue might delay or reverse neurodegeneration in Alzheimer's disease is as an inhibitor of Tau protein aggregation. While methylene blue arguably has an effect on Tau aggregation, it also has an effect on mitochondrial function which is likely to play an important role. In vitro studies suggest that methylene blue might be an effective remedy for both Alzheimer's and Parkinson's disease by enhancing key mitochondrial biochemical pathways. It can disinhibit and increase complex IV, whose inhibition correlates with Alzheimer's disease. Methylene blue might also delay senescence as one study has shown that it extended the lifespan of IMR90 fibroblasts by more than 20 population doublings..."

reverett123 06-23-2009 01:47 PM

Bought a bottle today at the local PetLand. Five bucks for a lifetime supply. You KNOW they are going to fast track this one.....:D

I'm going to wait a couple of weeks to clear up some other things, but will report back then.

lurkingforacure 06-23-2009 04:08 PM

Beware side effects...
 
I read somewhere that this causes green urine and blue where the whites of our eyes are, and think it is the same thing....used in the military years ago until they discovered these unsavory side effects. Anyone know, I guess Rick will report whether his wife freaked out when he opens his eyes in the morning!!!

reverett123 06-23-2009 04:44 PM

As best I can tell the doses are too low for the "Dune" look and the blue pee thing is no problem. In fact, the doses are so low that it is like the LDN. Also, if anyone else is considering this, I have run across some discussion that indicates that where the popular press was talking about milligrams that the actual work was in micrograms. A bit of a difference. See http://groups.google.ms/group/sci.li...178fcaaf4eed25


Quote:

Originally Posted by lurkingforacure (Post 527515)
I read somewhere that this causes green urine and blue where the whites of our eyes are, and think it is the same thing....used in the military years ago until they discovered these unsavory side effects. Anyone know, I guess Rick will report whether his wife freaked out when he opens his eyes in the morning!!!


Heidi L 06-26-2009 07:11 PM

Methylene Blue inactivates herpes viruses.
Alzheimer's plaques contain HSV1 particles.

95% of Parkinson's patients show HSV1 immune response.


The herpes connection to PD has been known for almost a century and yet nobody has ever done a clinical trial of Acyclovir on PD. Fast track indeed...


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