NeuroTalk Support Groups - New Study Proves that Pain is Not a Symtom of Arthritis, Pain Causes Arthritis.

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- Reflex Sympathetic Dystrophy (RSD and CRPS) (https://www.neurotalk.org/reflex-sympathetic-dystrophy-rsd-and-crps-/)

- - New Study Proves that Pain is Not a Symtom of Arthritis, Pain Causes Arthritis. (https://www.neurotalk.org/reflex-sympathetic-dystrophy-rsd-and-crps-/55745-study-proves-pain-symtom-arthritis-pain-causes-arthritis.html)

New Study Proves that Pain is Not a Symtom of Arthritis, Pain Causes Arthritis.

This is very interesting and includes other inflamitory conditions..
I can't help but wonder at the conectivity of spread of RSD and the spread of inflamation somehow..

http://www.rsds.org/electronic%20ale...22008_138.html

Quote:

Pain is more than a symptom of osteoarthritis, it is an inherent and damaging part of the disease itself, according to a study published today in journal Arthritis and Rheumatism. More specifically, the study revealed that pain signals originating in arthritic joints, and the biochemical processing of those signals as they reach the spinal cord, worsen and expand arthritis. In addition, researchers found that nerve pathways carrying pain signals transfer inflammation from arthritic joints to the spine and back again, causing disease at both ends

There is alot more to this artical, any thoughts?

Dear Sandra -

I thought it was an interesting article and one that ties in well to another recent piece I just attached to a posting under the "Inflamation, any tips to reduce" thread:

. . . there's been recent work done that shows the mechanism of "Association of catastrophizing with interleukin-6 responses to acute pain," Robert R. Edwards at al, Pain epub 2008.07.24, a copy of which is attached for anyone who's interested. It's a very interesting article that can probably be read on a number of levels, but it basically demonstrates that “catastrophizing” produces inflammatory cytokines in and of itself. . . ."

http://neurotalk.psychcentral.com/thread55412.html

I have a pdf copy of the Fiorentino article to which you refer and will be happy to email it to anyone who drops me their email in a PM. (It's too large to attach here.)

What's going on here is that people have for a long time been saying "I see cytokines, therefore RSD must be inflammatory in origin." I know that I took myself out to Johns Hopkins a couple of years ago and sought to get in on a trial of an anti IL-6 drug: fortunately I was refused. The message here is that a number of folks, including perhaps even Anna Louse Oaklander, M.D., may have gotten the causality on this thing backwards. See, "Editorial: RSD/CRPS: The end of the beginning," Pain, epub 2008.08.06, a copy of which is attached.

Mike