Swiss Company Ethos' PDEase
 

Anyone have any thoughts about this? The study, reported in full on their website, shows impressive results (still have to take Ldopa, just makes it much more effective...)

TAGERWILEN, SWITZERLAND - October, 2008 /PRAvenueNW/ - Ethos, the Swiss based pharmaceutical company that made the headlines back in 2003 with their 'miracle eye drops' that dissolve cataracts naturally without the need for invasive surgery ( www.ethos.ag ) and again in 2006 with their 'miracle anti-aging face cream' (www.rejuvion.com) have now made an incredible breakthrough for Parkinson's Disease sufferers the world over.

Finally, they have made a revolutionary new breakthrough in the treatment of Parkinson's Disease. Ethos Endymion PD Ease is not some new wonder drug but is an all natural substance found within all of our bodies that depletes with age. Ethos Endymion PD Ease is the purest form of this natural substance found anywhere in the world and
is also certified as 'bio-active' by Professor Gallant and Professor Boldyrev who are the world leading authorities on this compound and who we have to thank for proving the beneficial effects it gives Parkinson's Disease sufferers through their latest clinical trial. Not all people with Parkinson's have a hard time doing things most of us take for granted such as being able to walk and use our hands. With Parkinson's disease, daily life becomes first laborious, then impossible. Possibly even more debilitating, Parkinson's disease gradually deteriorates brain cells, so that thinking becomes more and more scrambled.

Ethos Endymion PD Ease crosses the blood-brain barrier where it goes to work repairing damage at a cellular level, which in turn helps to relieve the symptoms of Parkinson's Disease. To read a personal testimonial and a much more detailed and technical explanation, please review the Ethos PD Ease website: www.pdease.com

http://www.ipdgroup.com/pr-news/1048...ease-sufferers

L-Carnosine
 

that's what they say it is. Everette, what does all this mean? http://caprofile.net/CARNOSINEwarning1.html - I'm stumped.
Is this product more than Russian (researchers) hype?:confused: ibby

The title of their article calls it Carnisone and in the article it is called Carnosine. Why??

http://www.pdease.com/Ethos_PD_Ease.pdf

Only 20 patients took the carnosine.

They used Sevitine tablets which contain carnosine and are commercially available as a food additive.

http://www.google.com/search?hl=en&r...ts&btnG=Search

A book about carnosine:

http://books.google.com/books?id=d82...sult#PPA247,M1

Arch Pharm (Weinheim). 2008 Jul;341(7):412-7.
New L-dopa codrugs as potential antiparkinson agents.
Sozio P, Iannitelli A, Cerasa LS, Cacciatore I, Cornacchia C, Giorgioni G, Ricciutelli M, Nasuti C, Cantalamessa F, Di Stefano A.

Dipartimento di Scienze del Farmaco, Università G D'Annunzio, Chieti, Italy.

This paper reports the synthesis and preliminary evaluation of new L-dopa (LD) conjugates (1 and 2) obtained by joining LD with two different natural antioxidants, caffeic acid and carnosine, respectively. The antioxidant efficacy of compounds 1 and 2 was assessed by evaluating plasmatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the rat. Rat striatal concentration of LD and dopamine (DA), and central nervous effects were evaluated after oral administration of the codrugs 1 and 2.

The results suggest that, though our codrugs are devoid of significant antioxidant activity, they are able to induce sustained delivery of DA in rat striatum and can improve LD and DA release in the brain.

http://www.ncbi.nlm.nih.gov/pubmed/18581391

Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide

Abstract Ageing and neurodegenerative conditions are often associated with proteasome dysfunction, possibly mediated by zinc and/or copper ions. Studies have shown that (i) the olfactory lobe is normally enriched in carnosine and zinc, (ii) carnosine can suppress copper and zinc toxicity in olfactory neurones, (iii) olfactory dysfunction is often associated with neurodegenerative conditions and (iv) elevated levels of zinc are found in brains of Alzheimer’s patients. It is suggested that nasal administration of carnosine should be explored as a possible way of suppressing zinc/copper-mediated proteasome inhibition and consequent neurodegeneration.

Alan R. Hipkiss

2004

http://www.springerlink.com/content/...p/fulltext.pdf



*********************
Carnosine fights brain disease
By Ben Wasserman
Sep 22, 2008


Monday Sep 22, 2008 (foodconsumer.org) -- Chinese scientists reviewed studies and said carnosine or beta-alanyl-L-histidine found in animal tissue such as brain and skeletal muscle tissue can help fight many disease of central nervous system including Alzheimer's disease, Parkinson's disease and cerebral ischemic diseases.



The authors said carnosine is a potent hydrophilic antioxidant, anti-glycating agent and reactive oxygen species scavenger and pH-buffer.



The review titled Carnosine and diseases of central nervous system was conducted by Shen Y, Hu WW, and Chen Z. at Zhejiang University in Hangzhou, China and published in March 2007 issue of Zhejiang Da Xue Xue Bao Yi Xue Ban.

Biochemistry (Mosc). 2000 Jul;65(7):807-16.
Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection.
Trombley PQ, Horning MS, Blakemore LJ.

Biochemistry (Mosc). 2000 Jul;65(7):807-16.Click here to read Links
Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection.
Trombley PQ, Horning MS, Blakemore LJ.

http://www.ncbi.nlm.nih.gov/pubmed/10951099

Carnisone or L-Carnosine?
 

ZF,
I noticed that too. Thank you for digging on this one. I am incapable of doinig so in numerous ways!
I like the nosedrop idea. Beats 170$ tubof it that you have to sip all day.
Please let us know iiif you follow this somewhere good! Thanks, Ibby

Is your work Chemistry?

Zf ...
 

I am a bit slow here, are you saying there is some scientific support for this drug ....

or not ?

Neil.

Yes, but it's not a drug. It's a food additive, food supplement, available at IHerb.com and elsewhere.
There is science behind it, and in the small clinical trial, it was helpful.

I'm going to buy some and try it.

Zf ...
 

Is it the l-carnosine you are trying and how does this differ from carnosine, (what does the "l" mean ?) ?

Neil.