inhaler for diabetes, why not PD?
 

Here's a news article heralding an inhaler for diabetes...which was a topic here just a week or so ago, an inhaler for PD. This article also has a brief discussion on PD:

http://www.dailymail.co.uk/health/ar...s-recover.html

Hello,
Thanks for another interesting article. Let me try to answer your question. Of course there are others people in this forum who know much more than I do regarding this subject.

Intranasal is one of the best ways send a drug to brain, but the problem is with dopamine. It has be coated with something or formulated (as in the article you posted) so that it doesnt react or irritate the nasal mucosal layers or the lungs. Second degree of difficulty is it is a small molecule and has both activating and inhibitory properties depending on which receptor it binds to. So any coating substance used has to preserve its native structure to certain extent for Dopamine to work the way it should.
Insulin which is what the article talks about, is a protein and I guess is relatively easier to formulate than Dopamine. Dopamine is a very small molecule and possibly loses its configuration and function when formulated. If the formulation is good, Dopamine inhalation should work.

This is my theory! Any other thoughts?

Girija

Not intranasal
 

Hi Lurkingforacure,
The inhaler you describe is not for the nose, where there is a direct connection to the brain. It is an oral inhaler and the drugs go into the lungs then bloodstream. Since they go into the bloodstream it is similar to taking drugs by mouth.
Girija is right about the difficulty of formulating dopamine into a nasal (not mouth) spray.It could damage the delicate nose lining, with repeated use. It would be interesting to try a single experiment though, to confirm it works.
Ron
PS Did you read my reply to your question in the virus thread?

I did thanks
 

Thanks as always for sharing your knowledge...I did read it, and was going to post a news article about "rogue" immune cells being thought to contribute to PD, the timing is very coincidental to me since this has been a topic of late. I will post that article as a new thread, it seems similar yet different to the link I posted 12/23 on this forum.