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- Myasthenia Gravis (https://www.neurotalk.org/myasthenia-gravis/)

- - magnesium (https://www.neurotalk.org/myasthenia-gravis/7254-magnesium.html)

hi need to know something my friend also has MG and she just told me that she has been taking magnesium i thought you could not take this if you have MG she says that she has had no side effects and no weakness how is this possible she is neg for antibodies but everything else was positive

I am curious about this... so I researched it for you:

Quote:

Muscle Nerve. 1990 Aug;13(8):708-12. Links
Myasthenia gravis presenting as weakness after magnesium administration.

* Bashuk RG,
* Krendel DA.

Emory University School of Medicine, Department of Neurology, Atlanta, Georgia.

We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usually well tolerated. The magnesium was stopped and she recovered over a few days. While she was weak, 2-Hz repetitive stimulation revealed a decrement without significant facilitation at rapid rates or after exercise, suggesting postsynaptic neuromuscular blockade. After her strength returned, repetitive stimulation was normal, but single fiber EMG revealed increased jitter and blocking. Her acetylcholine receptor antibody level was markedly elevated. Although paralysis after magnesium administration has been described in patients with known myasthenia gravis, it has not previously been reported to be the initial or only manifestation of the disease. Patients who are unusually sensitive to the neuromuscular effects of magnesium should be suspected of having an underlying disorder of neuromuscular transmission.

PMID: 2385256 [PubMed - indexed for MEDLINE]

This was high dose IV treatment mentioned in the article.

and this:
http://www.digitalnaturopath.com/cond/C491841.html
also refers to LARGE doses.

You know you can get magnesium from food. 3 ounces of unsalted almonds have 270mg in them. This might be the best way for you to get your mag.;)

thanks but i would never try it i have to many problems right now , i dont want to add to it , i just cant understand why it does not affect her she has had MG longer then i have and i have a feeding tube and she seems to be doing great maybe it works for her , but thanks for finding that site it is very interesting or maybe she is in some kind of remission well i guess what ever works for her thanks again

Littlewish, mrsd is quite correct, the amount necessary to cause weakness in a myasthenic is a very high dose. The amt of magnesium found, for example, in a vitamin pill, is just not a high enough dose to cause any problems. Actually, a certain amount of magnesium is not only beneficial, it's absolutely necessary for good health. I've taken a multivitamin for years that contains magnesium, and have never had any problems with it at all. Remember, even something as necessary and beneficial as is Mestinon to an MGer will cause weakness if one takes too much.
Hugs,