NeuroTalk Support Groups - Migraine Mice Exhibit Enhanced Excitatory Transmission At Cortical Synapses

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03-12-2009 01:10 PM

Migraine Mice Exhibit Enhanced Excitatory Transmission At Cortical Synapses

Main Category: Headache / Migraine Also Included In: Neurology / Neuroscience ; Biology / Biochemistry ; Genetics Article Date: 12 Mar 2009 - 2:00 PDT New research is unraveling the complex brain mechanisms ...

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(From Topix Neurology)

Jaspar

03-12-2009 01:38 PM

Quote:

calcium influx and subsequent glutamate release at cortical pyramidal cell synapses were increased in mice carrying the FHM mutation. Glutamate is the major excitatory neurotransmitter in the brain. The facilitation of induction and propagation of CSD in the FHM mice was completely eliminated when glutamate release was decreased to control levels. Importantly, in contrast with the enhanced excitatory neurotransmission, inhibitory neurotransmission was not altered in the migraine mice.

This further blurs the line between neurology and psychiatry.

Doody

03-12-2009 02:20 PM

I feel sorry for the mice.

Jaspar

03-13-2009 10:09 AM

Quote:

Originally Posted by Doody (Post 480008)

I feel sorry for the mice.

Agreed. Like the mice driven insane with torture in order to mimic the stress effects in schizophrenia.

You will not see me working in one of those labs.

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