NeuroTalk Support Groups - Anodyne Therapy

Hi Sailprice...
I think you should add in acetyl carnitine (up to 2 grams a day)
and r-lipoic acid.

Start with 500mg of the carnitine daily and work up if necessary.
When you increase, take in divided doses, since it is not all absorbed in one bolus type dose.

R-lipoic is a newer version of alpha lipoic and more potent.
Start at 50mg of this. I use 100mg/day BTW.

Make sure your CoQ-10 is a quality type, with absorption enhancing qualities. Plain old powder capsules without Bioperine, are most likely not being absorbed well.

Some makers assure on the label, the enhancing vehicle for the CoQ-10. I'd take more than 100mg (more like 200mg) because of the statin.

Examples of quality CoQ-10:
http://www.epic4health.com/noname.html
or
http://www.iherb.com/Doctor-s-Best-H...e-Caps/20?at=0

If you opt for the Doctor's Best with Bioperine, take it away from any other drugs you use. It will enhance absorption of RX drugs as well, and these have specific absorption qualities for their dosing and you may end up with MORE drug than you need. So take them at least 6 hrs apart.

Regarding Bioperine:
I just looked around on PubMed for this additive for studies and found THIS:

Quote:

Phytother Res. 2009 Jan 26. [Epub ahead of print]Click here to read Links
Antihyperlipidemic Compounds from the Fruit of Piper longum L.
Jin Z, Borjihan G, Zhao R, Sun Z, Hammond GB, Uryu T.

Institute of Macromolecular Chemistry and Mongolian Medicine, Inner Mongolia University, Huhhot 010021, China.

A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin. Copyright (c) 2009 John Wiley & Sons, Ltd.

PMID: 19172581 [PubMed - as supplied by publisher]

from http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

Also I checked Dr. Sahelian's site, and he suggests periodic rests from piperine extracts.
But the link to potential lowering of cholesterol is interesting here with it.

This newer paper suggests that piperine is safe:

Quote:

Crit Rev Food Sci Nutr. 2007;47(8):735-48.Click here to read Links
Black pepper and its pungent principle-piperine: a review of diverse physiological effects.
Srinivasan K.

Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India. ksri.cftri@gmail.com

Black pepper (Piper nigrum) is one of the most widely used among spices. It is valued for its distinct biting quality attributed to the alkaloid, piperine. Black pepper is used not only in human dietaries but also for a variety of other purposes such as medicinal, as a preservative, and in perfumery. Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive enzymes of pancreas, enhances the digestive capacity and significantly reduces the gastrointestinal food transit time. Piperine has been demonstrated in in vitro studies to protect against oxidative damage by inhibiting or quenching free radicals and reactive oxygen species. Black pepper or piperine treatment has also been evidenced to lower lipid peroxidation in vivo and beneficially influence cellular thiol status, antioxidant molecules and antioxidant enzymes in a number of experimental situations of oxidative stress. The most far-reaching attribute of piperine has been its inhibitory influence on enzymatic drug biotransforming reactions in the liver. It strongly inhibits hepatic and intestinal aryl hydrocarbon hydroxylase and UDP-glucuronyl transferase. Piperine has been documented to enhance the bioavailability of a number of therapeutic drugs as well as phytochemicals by this very property. Piperine's bioavailability enhancing property is also partly attributed to increased absorption as a result of its effect on the ultrastructure of intestinal brush border. Although initially there were a few controversial reports regarding its safety as a food additive, such evidence has been questionable, and later studies have established the safety of black pepper or its active principle, piperine, in several animal studies. Piperine, while it is non-genotoxic, has in fact been found to possess anti-mutagenic and anti-tumor influences.

PMID: 17987447 [PubMed - indexed for MEDLINE]

from http://www.ncbi.nlm.nih.gov/pubmed/17987447?ordinalpos=1&itool=EntrezSystem2.PEntrez. Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.P ubmed_Discovery_RA&linkpos=4&log$=relatedreviews&l ogdbfrom=pubmed