NeuroTalk Support Groups - Metoclopromide or Reglan cause TD????

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Metoclopromide or Reglan cause TD????

I have been taking Reglan for over a year for gastrointestinal motility, to keep foods from sticking in my chest. It also helps immeasurably with the back pain - sever - that I used to have in conjunction with the motility problem. After my doctor mentioned that it had some [unspecified] side effects, I cut down dosage no one per day in the AM. Over past several months I have noticed a grinding of my teeth, almost constantly. Could this be the beginning of Tardive Dyskinesia? Thanks to anyone who might have info. I don't know of anything that might substitue for Reglan. :confused:

Quote:

Metoclopramide is a gastrointestinal prokinetic agent used in the treatment of symptomatic gastroesophageal reflux disease and diabetic gastroparesis. In addition, injectable metoclopramide is used to prevent nausea and vomiting following chemotherapy and facilitate small bowel intubation and radiological examinations. As an antidopaminergic agent, metoclopramide can cause tardive dyskinesia (TD), a syndrome characterized by persistent, potentially irreversible, abnormal involuntary movements. (http://www.medscape.com/viewarticle/498144)

Here's a definition of TD for you, but as you're obviously having side effects to this medication, you'll need to see your doctor so any problems don't progress to irreversable. They are other medications that will do the same job as this drug.... maybe you just need a change.

Quote:

...Tardive dyskinesia is characterized by repetitive, involuntary, purposeless movements. Features of the disorder may include grimacing, tongue protrusion, lip smacking, puckering and pursing of the lips, and rapid eye blinking. Rapid movements of the extremities may also occur.... (http://en.wikipedia.org/wiki/Tardive_dyskinesia)

Quote:

Originally Posted by Koala77 (Post 542834)

I couldn't find any reference particularly to grinding of the teeth as a side effect Billie, but I did find lots of information related to the drug and TD, so maybe you're right. I hope not though.

Metoproclamide is one of those medications that you should never take more often than's ordered, but the literature says not to take it for than 3 months. Long term use causes tremors and/or uncontrollable muscle movements, especially in older women, so maybe it's time for a change.

Here's a definition of TD for you, but as you're obviously having side effects to this medication, you'll need to see your doctor so any problems don't progress to irreversable. They are other medications that will do the same job as this drug.... maybe you just need a change.

My gastro doc did not want me on Metacloprimide long term because of worries about Tremor problems. He put me on Domperidone for my gastroparesis because it doesnt cross the blood brain barrier. I have to order it from Canada but docs in the US can prescribe it.

Are you also using an SSRI type drug? These also cause jaw/mouth/neck spasms when used for over 6mos, in some people.

You could try taking some B6 in the form of P5P (the activated form). B6 can help tardive in some people.

http://www.ncbi.nlm.nih.gov/pubmed/18052557