Just thought I'd post up an update on my toes. I found out about a transdermal PLO gel base that can be used with pain management drug delivery into the skin as opposed to orally. Its standard practice and widely available in the USA/CA, but not in the UK or EU.

I managed to track down a specialist compounding pharmacy in London, UK **that compounds in an imported PLO gel from Canada called Medisca VersaPro gel. I just received it last week (£45 for 100g) with 10% amitriptylene compounded into it and have been testing it out. So far results have been good. I put it on before walking and it seems to stop the erythema leading to the stinging pain. When I run it seems to come back, but I need to do more testing before anything is definitive.

For me transdermal drug delivery is so much more preferable to orally taking drugs with all the side effects as I just can't focus on my work and don't like feeling semi comatose.

The NHS is currently trying to fast track something very similar called AmiKet - which is essentially the same thing with 2% ketamine added to the mix.

Anyway just thought I'd share my info in case it can help others who have not heard or considered this type of drug treatment