[misreable]

Hi All
Inflammation is this or is it not part of the symptom's and pain associated
with RSD? have read all the articles on this- still do not under stand why they
do not recommend taking NSAID'S for this- I was on ETODOLAC (LODINE) 200mg. Had to stop was having kidney problems- also have been told not to take inflamatory med's with any pain relief medication- as soon as I stopped the LODINE- (the kidney problems went away)-- back is starting to burn some
now - a lot more after stretching. THANKS ADA for the WD. article we sure
could use more of this.
Take Care
Susan

[dreambeliever128]

I tried taking over the counter meds a few weeks ago for inflamation in my hip and pelvic are and they actually did seem to help but I had to quit them due to GERD and PUD. It made me worse and even the prevacid didn't help settle the problems.



How are you doing? I was just thinking of you yesterday. I hadn't heard from you via PM for a few days. I was hoping you were ok.

Ada

[misreable]

Hey Ada
Do you know anything about the inflammation problem? don't start ph.
till next MON--looking forward to it--loved that article forward it on to my MOM
who doesn't seem to under stand any thing I'M telling her.I didn't know you had
MS my husband was just diagnosed with this 4 months ago he is on REBIF Injections 3t.a wk. I think I read you had this? how much more can you deal with? Take Care SUSAN

[fmichael]

Dear Miserable -

By coincidence, I put up a thread yesterday regarding a new online article dealing directly with the inflamatory mechanism in CRPS. "Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1," J George Groeneweg et al, BMC Musculoskelet Disord. 2006; 7: 91. http://www.pubmedcentral.nih.gov/art...medid=17137491 and posted here at http://neurotalk.psychcentral.com/sh...ad.php?t=13221

For a couple of earlier studies by largely the same group of authors, check out the following:

1. "Evidence for local inflammation in complex regional pain syndrome type 1," Frank J P M Huygen, Anke G J De Bruijn, Martha T De Bruin, J George Groeneweg, Jan Klein, and Freek J Zijistra, Mediators Inflamm. 2002 February; 11(1): 47–51 at http://www.pubmedcentral.nih.gov/art...medid=11930962 and

2. "Intermediate Stage Complex Regional Pain Syndrome Type 1 Is Unrelated to Proinflammatory Cytokines," Renate J. M. Munnikes, Christel Muis, Martine Boersma, Claudia Heijmans-Antonissen, Freek J. Zijlstra, and Frank J. P. M. Huygen, Mediators Inflamm. 2005; 2005(6): 366–372 (as described in their most recent article, this study looked at "patients with an intermediate duration of CRPS (median 20 months) and . . . found a significant elevation of IL-6 and TNF-α in the involved extremity compared with the uninvolved extremity") at http://www.pubmedcentral.nih.gov/art...medid=16489257

For what is probably the best known study in the area, you can also take a look at "Changes in Cerebrospinal Fluid Levels of Pro-inflammatory Cytokines in CRPS," Alexander GM, van Rijn MA, van Hilten JJ, Perreault MJ, Schwartzmann RJ, Pain 2005;116:213-219. A copy of the article can be downloaded from the RSDSA Medical Articles Archive page at http://www.rsds.org/2/library/articl...ive/index.html The article appears at about the middle of the page, under the heading "Research," where it is listed aphabetically by author.

I hope this is helpful. (These are all free full-text copies.)

Mike

[fmichael]

p.s. to my last. A friend of mine was just kind enough to send me a copy of a relatively new article, "Advances in treatment of complex regional pain syndrome: recent insights on a perplexing disease," Amit Sharma at al, Curr Opin Anaesthesiol. 2006 Oct;19(5):566-72.

The article is short enough to be posted here, and includes a brief discussion of treatment with anti-inflammatory drugs.

I hope it's helpful.

[misreable]

Hi Mike
Thanks so much for all the info. lots to read--have an appt. with my neuro Dr. next week see what kind of answer he might have-any thing you might have in future would appreciate.
THANK'S AGAIN
SUSAN