PRIALT is known as an N-type calcium channel blocker, which means it blocks the channels on pain- sensing nerve cells. Once the channels are blocked, calcium cannot enter and pain signals cannot travel to the brain PRIALT is indicated for the management of severe chronic pain in patients for whom intrathecal (IT) therapy is warranted, and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies or IT morphine. I've heard it is expensive but highly effective. www.prialt.com Posted by: Man-ala-pan on Wed Aug 29, 2007 1:30 pm --------------------------------------------------------------------------

Has anyone tried this?

Deb

some have had this and had awful side effects-who knows?

Before anyone writes off Prialt based on reports of side effects while using the pump, check out Michael Stanton-Hicks amazing little report:

"An Effective Treatment of Severe Complex Regional Pain Syndrome Type 1 in Child Using High Doses of Intrathecal Ziconotide (Letter to the Editor)," Stanton-Hicks MD, Kapural L, Journal of Pain and Symptom Management, 2006; 6: 509-510.

You can open it on the RSDSA Medical Articles Archive page at http://www.rsds.org/2/library/articl...ive/index.html then scroll down, it's listed alphabetically by author under the heading "Treatment."

Mike

I had an infusion of Aredia which I think is the same? but not sure- I tried to email my old PM, who is moving, but got no response.

Thanks for the info

Debbie

Deb -

Aredia is a brand name of Pamidronate [http://www.nlm.nih.gov/medlineplus/d.../a601163.html], a bisphosphonate, which to the best of my understanding is not a calcium channel blocker.

For an earlier thread on Zometa as Pamidronate+ - and one that infuses in only 15 minutes - see, http://neurotalk.psychcentral.com/sh...ad.php?t=24411.

Mike

I found this about Aredia -
[Aredia®
pamidronate disodium for injection
For Intravenous Infusion

Rx only
DESCRIPTION

Aredia, pamidronate disodium (APD), is a bone-resorption inhibitor available in 30-mg or 90-mg vials for intravenous administration. Each 30-mg, and 90-mg vial contains, respectively, 30 mg and 90 mg of sterile, lyophilized pamidronate disodium and 470 mg and 375 mg of mannitol, USP. The pH of a 1% solution of pamidronate disodium in distilled water is approximately 8.3. Aredia, a member of the group of chemical compounds known as bisphosphonates, is an analog of pyrophosphate. Pamidronate disodium is designated chemically as phosphonic acid (3-amino-1-hydroxypropylidene) bis-, disodium salt, pentahydrate, (APD), and its structural formula is

Pamidronate disodium is a white-to-practically-white powder. It is soluble in water and in 2N sodium hydroxide, sparingly soluble in 0.1N hydrochloric acid and in 0.1N acetic acid, and practically insoluble in organic solvents. Its molecular formula is C3H9NO7P2Na2·5H2O and its molecular weight is 369.1.

Inactive Ingredients. Mannitol, USP, and phosphoric acid (for adjustment to pH 6.5 prior to lyophilization).
Next: Aredia - Clinical Pharmacology »]
copied from & more at link below -
http://www.rxlist.com/cgi/generic/aredia.htm