Hi there
Alison is currently taking 75mg of Lyrica three times daily
I collected our new prescription form my Pharmacy at the end of last week as our supply of Lyrica ran out over the weekend
When I opened the box I notice the tablets looked different and when I looked closer the Pharmacy had dispensed 200mg tablets so if I hadn't noticed Alison would have been taking 600mg a day
I have no idea if the mistake was made by our GP or the Pharmacy as both are closed over the weekend
Consequently Alison hasn't had her Lyrica over the weekend and has had trouble sleeping as a result (it makes no differnece to her pain)
I know the maximum dose for adults is 600mg daily but as Lyrica is not advised for use in children I have no idea what (if any) the recommended dosage should be
The drug manufacturers website states:
The safety and efficacy of pregabalin in pediatric patients have not been
established.
In studies in which pregabalin (50 to 500 mg/kg) was orally administered to
young rats from early in the postnatal period (Postnatal Day 7) through sexual
maturity, neurobehavioral abnormalities (deficits in learning and memory, altered
locomotor activity, decreased auditory startle responding and habituation) and
reproductive impairment (delayed sexual maturation and decreased fertility in
males and females) were observed at doses ≥50 mg/kg. The neurobehavioral
changes of acoustic startle persisted at ≥250 mg/kg and locomotor activity and
water maze performance at ≥500 mg/kg in animals tested after cessation of
dosing and, thus, were considered to represent long-term effects. The low effect
dose for developmental neurotoxicity and reproductive impairment in juvenile
rats (50 mg/kg) was associated with a plasma pregabalin exposure (AUC)
approximately equal to human exposure at the maximum recommended dose of
600 mg/day. A no-effect dose was not established.
Reading about reproductive imparement really scares me - what implications might taking this drug now have on Alisons future health and well-being !!!!
As I say, Alison never took the 600mg I prescribed but I have grave concerns about what would have happened if she had taken it
Any advice would be welcome - particularly any studies of the long term use of this drug in children
Thanks
Andrea