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Reflex Sympathetic Dystrophy (RSD and CRPS) Reflex Sympathetic Dystrophy (Complex Regional Pain Syndromes Type I) and Causalgia (Complex Regional Pain Syndromes Type II)(RSD and CRPS) |
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12-02-2008, 09:43 AM | #1 | |||
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This is a really important study. Here's the PubMed abstract:
The Brain in Chronic CRPS Pain: Abnormal Gray-White Matter Interactions in Emotional and Autonomic Regions.Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, Apkarian AV. Neuron. 2008 Nov 26;60(4):570-81.http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum Separately in a CBC News story distributed by the RSDSA, the authors suggest that: "This is the first evidence of brain abnormality in these patients," said the study's lead investigator, Vania Apkarian, a professor of physiology at Northwestern University's Feinberg School of Medicine in Chicago.http://www.rsds.org/electronic%20ale...12008_147.html And for what it's worth, Vania Apkarian is probably the leading neuroscientist in the world on matters relating to pain, so I take his comments from the CBC News story as significant in their own right. Mike Last edited by fmichael; 12-02-2008 at 12:17 PM. |
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"Thanks for this!" says: | CZZ74 (12-06-2008), daylilyfan (12-06-2008), Imahotep (12-17-2008), JOAN_M (12-03-2008), kejbrew (12-02-2008), loretta jewell (12-03-2008), mollymcn (12-03-2008) |
12-03-2008, 12:16 PM | #2 | |||
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A friend of mine just sent me the article:
The Brain in Chronic CRPS Pain: Abnormal Gray-White Matter Interactions in Emotional and Autonomic Regions.Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, Apkarian AV. Neuron. 2008 Nov 26;60(4):570-81.It is exceptionally well illustrated, if neccesarily technical. Because it's too large to post here or send by PM, if you want to look it over just drop me a PM with your email address and I'll send it on out: for personal use only, please. It might be something worth sharing with your pm docs. Mike |
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"Thanks for this!" says: | kejbrew (12-03-2008), loretta jewell (12-03-2008) |
12-03-2008, 07:19 PM | #3 | |||
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Thank you! I will send you a pm with my email. I am also curious as to the effects HBOT has on the brain. I have been doing a little research on that. I still have a lot to learn after all these years.
Di |
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12-04-2008, 12:08 AM | #4 | |||
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Senior Member
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Quote:
Mike Last edited by fmichael; 12-04-2008 at 08:02 PM. Reason: local color |
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"Thanks for this!" says: | DianaA (12-04-2008), loretta jewell (12-09-2008) |
12-04-2008, 01:04 PM | #5 | |||
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Senior Member
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In correspondence with a member this morning, I remembered that I had not been explict with respect to the relationship between thalamocortical dysrhythmias and the topic at hand, CRPS.
Basically, if you take up the invitation to read the article, you have to bear in mind the key metaphor for the structures of the brain, they are empty, just as the tornado is only wind. But that does not make it nothing. (And the references throughout the article to Eigenvalues are just a term from linear algebra relating to values of normal occillation.) In fact, there are a lot of folks who think that all creation is vibration, the only thing fixed and static are the definitions we construct, each of which must relate to another term or concept to define them, hence they are called relational. But I go on . . . . Mike Last edited by fmichael; 12-04-2008 at 07:39 PM. Reason: sp |
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"Thanks for this!" says: | DianaA (12-04-2008) |
12-04-2008, 06:18 PM | #6 | |||
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Senior Member
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Quote:
I seem to recall something about how it was believed that HBOT's mechanism of action was it's effect of the brain, and perhaps specifically the thalamus. Can you bring us up to date? Mike |
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12-05-2008, 10:09 AM | #7 | |||
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Magnate
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Thank you for posting this - it is great news if it is true and brings us all hope!
I'm going to speak to my PM Doctor about it and see what he says - sometimes we find interesting articles that he has never seen before!
__________________
To the World you may be one person, but to one person, you may be the World. |
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12-05-2008, 05:32 PM | #8 | |||
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I think that you are much better at the researching than I am. Maybe you could take some time and pull up a few sites that might be of interest to all of us. I have some listed in my favorites, but I am just not sure how to get them on the post. There seems to be a lot more research and research studies, requesting people for clinical studies on the govtrials.com web site as well. I am currently doing a series of dives at home 2.2ata and just not up to the task. I don't want to misquote by just throwing out what I have read about HBOT and the effects on the brain. There are also a few new Utube sites on HBOT and Brain injury, effects etc. Maybe you could help present some of this information. If not, I'll get back to you I just am short of hours. 1 1/2 hours in the am and pm for dives. I'll try to get someone to do this for me if you can't help at this time. I do think we would all find this very interesting. I'll get back to you. Diana
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12-15-2008, 05:02 PM | #9 | ||
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Hi Guy,
Just came across your post. Bumping up because I am very interest in the white and grey matter volume in the brain. The why and what is what is bothering me. Bless You Mike for caring. Roz |
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12-17-2008, 08:27 PM | #10 | |||
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Senior Member
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Okay. I'll admit to being pretty lethargic and ignoring responsibilities on the board over the last couple of weeks. To answer Diana's question about researching HBOT as a treatment for CRPS, I went to my "usual sources" and didn't come up with much. Going first to my the easiest reference page of all, the RSDSA Medical Articles Archive page at http://www.rsds.org/2/library/articl...ive/index.html we get one lone article from 1995:
Hyperbaric oxygen and the reflex sympathetic dystrophy syndrome: a case report. Peach G, Undersea Hyperb Med. 1995 Dec; 22(4): 407-8.A pdf photocopy of the article is available on the through RSDSA page at http://www.rsds.org/2/library/articl...Hyperbaric.pdf I then ran the article through PubMed - http://www.ncbi.nlm.nih.gov/pubmed/ - an online collection of medical articles and their abstracts maintained by the NIH, often with extensive cross-referencing, but found that the article in question was apparently never cited thereafter. At that point. I was left just running searches on PubMed. Doing that, I came up with a few abstracts, which are listed below. Unfortunately, none of these article are currently free, so you would have to (1) go to a medical library, (2) make the acquaintance of someone with access to a research university computer system, or (3) if you're lucky, once you've called up the individual article abstracts on PubMed you can then follow the available links to the publisher sites, which would in turn sell you copies of the article from anywhere from $20 to $35 each. In any event, here's what I came up with, and please note the distinctive international flavor in what follows: 1. Hyperbaric oxygen therapy in chronic pain management.Yildiz S, Uzun G, Kiralp MZ. Curr Pain Headache Rep. 2006 Apr;10(2):95-100.Pretty slim pickings overall, and none of the four abstracted articles listed above are even linked for online purchase at that, although I haven't tried accessing the publishers directly. Perhaps someone else will have better luck. Mike |
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