Reflex Sympathetic Dystrophy (RSD and CRPS) Reflex Sympathetic Dystrophy (Complex Regional Pain Syndromes Type I) and Causalgia (Complex Regional Pain Syndromes Type II)(RSD and CRPS)


advertisement
Reply
 
Thread Tools Display Modes
Old 11-27-2006, 08:01 AM #1
Annie Poo Annie Poo is offline
Junior Member
 
Join Date: Sep 2006
Posts: 85
15 yr Member
Annie Poo Annie Poo is offline
Junior Member
 
Join Date: Sep 2006
Posts: 85
15 yr Member
Default recent article showing impaired endothelial function in cold-type CRPS

(Give this to anyone who thinks you're faking it!)

Neurology. 2006 Aug 22;67(4):673-5.
Endothelial dysfunction in cold type complex regional pain syndrome.

Schattschneider J, Hartung K, Stengel M, Ludwig J, Binder A, Wasner G, Baron R.

The authors examined endothelial function in cold type chronic complex regional pain syndrome (CRPS) I using acetylcholine- and sodium nitroprusside-induced vasodilation combined with laser Doppler flowmetry in 14 patients and 10 controls. On the affected side, acetylcholine-induced vasodilation was significantly reduced in comparison to controls and the unaffected extremity. No significant differences were found after application of sodium nitroprusside. The results demonstrate impaired endothelial function in chronic CRPS I.
Annie Poo is offline   Reply With QuoteReply With Quote

advertisement
Old 11-29-2006, 11:26 PM #2
Vicc's Avatar
Vicc Vicc is offline
In Remembrance
 
Join Date: Nov 2006
Location: SE Kansas.
Posts: 374
15 yr Member
Vicc Vicc is offline
In Remembrance
Vicc's Avatar
 
Join Date: Nov 2006
Location: SE Kansas.
Posts: 374
15 yr Member
Default

I think the first time I mentioned impaired endothelial function was about 2000. If I don't get my butt in gear and write my article, these quacks will end up telling the truth themselves...Vic
Vicc is offline   Reply With QuoteReply With Quote
Old 12-01-2006, 10:29 PM #3
Debby's Avatar
Debby Debby is offline
Member
 
Join Date: Aug 2006
Location: N CA
Posts: 365
15 yr Member
Debby Debby is offline
Member
Debby's Avatar
 
Join Date: Aug 2006
Location: N CA
Posts: 365
15 yr Member
Default

Ok so if that all is the problem with cold type CRPS what the hell is the problem causing the HOT type CRPS????? Cause I deal with that most of the time. My feet are so darn HOT all the time. My toes are always a bright bright red, & they don't even swell anymore. (so why do I now have to buy size 11 D width shoes??? when I use to wear only a 10 B width. I can't even get them on without socks now) They burn & feel like I am walking on HOT COALS or crushed glass or how they feel when frost bitten. Most of my toe nails are icky. If I don't keep them a bit long now they grow into my toes big time. Has taken me forever to get them the way they are & I have to file & round them off constantly.

Then lately burning feelings go up my shim bones. And the surface of lower legs feel weird. One night every inch of my body burned almost. Or I felt numb like pins & needles type numb.

Back to my feet & ankles. The only big reason they don't turn cold is cause I wear leg warmers bunched around my ankles & warm slippers on. I did find some really kewl chenille socks that aren't all fluffy to wear in my shoes. But when they do get cold OH MY GOD............they still burn like hot coals. And when I try to get up in the morning YIKES it feels like I am on a narrow ledge & my feet HURT HURT HURT. I HATE THIS!!!!

Back to the subject...like I asked, what is the cause for the HOT feet???? then.....

AARRRGGGHHHHHHHHHHHHHH
Debby is offline   Reply With QuoteReply With Quote
Old 12-04-2006, 04:08 AM #4
Vicc's Avatar
Vicc Vicc is offline
In Remembrance
 
Join Date: Nov 2006
Location: SE Kansas.
Posts: 374
15 yr Member
Vicc Vicc is offline
In Remembrance
Vicc's Avatar
 
Join Date: Nov 2006
Location: SE Kansas.
Posts: 374
15 yr Member
Default

Hi Debby,

"Cold" RSD describes the 2nd stage of the disease, when skin temperature usually lowers and painful hypersensitivity to cold begins; it includes the painful burning and the allodynia too.

There is research showing endothelial impairment and destruction in RSD; what this means is that capillary walls, which are made up only of endothelial cells, have been damaged and destroyed. It isn't endothelial cell damage that causes the pain of RSD, however, it is that a huge number of microvascular systems (MVS) [the arterioles, capillaries and venules that make up what most of us refer to as capillaries], are no longer functioning.

Arterial blood is no longer reaching the cells through these MVS', and since all of our cells receive all of their oxygen and nutrients through arterial blood, those cells that depended upon the now destroyed MVS' first become hypoxic (oxygen deprived), then dystrophic (nutritionally deprived).

This disease was called RSD to explain the dystrophy, but when researchers proved the sympathetic nervous system (SNS) was not abnormally blocking blood flow, the originator of this hypothesis, Rene LeRiche, abandoned it. The rest of the medical profession has taken about 60 years to catch up with him. They spent many of those years pretending that cyanosis (that blue to purplish skin color) doesn't really exist; and destroying patient's circulatory systems by severing their sympathetic nerves (sympathectomies).

Many physicians have stopped pretending that SNS damage causes RSD and now pretend it is peripheral nerve damage (PND), but since PND cannot explain cyanosis, they still don't mention that word.

When we see this skin discoloration, what we actually see are capillaries close to the skin that are filled with hypoxic arterial blood. This blood is trapped in the MVS where its oxygen is leeched out, and there it sits, unable to pass back into a vein and be replaced by fresh arterial blood. MVS' below the skin are also cyanotic, but we can't see them.

The reason for "cold" RSD is that our soft tissue cells generate all of the heat in our bodies; when enough MVS' are destroyed, these cells can't get the oxygen and nutrients they need in order to function. It is by combining these two things that cells generate heat and meet their energy needs.

Not all of the MVS in an area are destroyed: If they had been, cells would begin to die and tissue become necrotic (gangrene), killing us in rather short order.

Our nerve cells need oxygen and nutrients too, and when they don't get enough, they become dysfunctional; pain sensory nerves send pain signals, while other sensory nerves (touch, etc), react to a breeze as if it were sandpaper on a sunburn. Other complex nerve dysfunctions are also taking place, but all of this seeming nerve damage is the result of hypoxia and dystrophy.

Hair and nails need oxygen and nutrients; when they don't get enough, nail growth slows and hair loss can occur. Bones also need arterial blood in order to replace calcium; without it, spotty osteoporosis results, with some parts of the bone still getting adequate arterial blood while others don't.

The only neurological explanation for inadequate arterial blood is SNS dysfunction, which isn't taking place; that's why they finally stopped calling it RSD and now call it CRPS.

These other signs, however, prove that this is more than a complex pain disorder: We may notice the pain most, but nerves; bone; muscle; MVS; and other cells are being destroyed too.

This is what endothelial dysfunction in CRPS really means, and if sodium nitropusside (vasodilation) had any lasting therapeutic effect, the cure to this disease might be at hand; but I suspect that widespread infusion affecting both damaged and undamaged MVS would pose life-threatening risks and even if effective would only be temporary,

As to your hot feet: the redness is usually a sign of continuing inflammation (the first stage of the disease). I don't know why this would continue, but there are many things I don't understand about this disease.

What I do understand, however, is that there is a disorder called ischemia-reperfusion injury that seems identical to RSD; the problem today is that IRI in internal organs was identified nearly 50 years ago, but only relatively recently in skeletal muscle. I strongly suspect that if the word "cyanosis" hadn't virtually vanished from the lexicon of RSD, more physicians knowledgeable about IRI might suddenly become intensely interested in this disease.

Eventually this secret will get out, however, and when that happens this neurological house of cards will collapse and effective therapies for RSD will finally begin. Meanwhile, I try to keep writing posts while I pray that I will eventually be able to finish my journal article. Even that will only help a few people, but a few more than are being helped now...Vic

Last edited by Vicc; 12-04-2006 at 12:53 PM. Reason: making minor word changes
Vicc is offline   Reply With QuoteReply With Quote
Old 12-04-2006, 05:37 AM #5
frogga's Avatar
frogga frogga is offline
Member
 
Join Date: Nov 2006
Location: UK
Posts: 830
15 yr Member
frogga frogga is offline
Member
frogga's Avatar
 
Join Date: Nov 2006
Location: UK
Posts: 830
15 yr Member
Default

Dear Vic

Thankyou so much for posting that - you have given me an insight into the physiological mechanisms of this disease in a way that other papers and doctors have failed. I am guessing this is why HBOT helps some people? as it reverses the tissue hypoxia and forces oxygen into the MVA?

Thanks!! hope you are ok

Rosie xxxxxxxxxxxxxxxx
__________________
It's always darkest just before dawn... but smile and the world smiles with you, cry and you cry alone
frogga is offline   Reply With QuoteReply With Quote
Old 12-04-2006, 10:38 AM #6
artist
Guest
 
Posts: n/a
artist
Guest
 
Posts: n/a
Default

Well Vic,

Whatever else you think may be going on in that brain of yours, you have not lost your marbles or the use of those grey cells...or your sense of humour...brilliantly clear, very many thanks,
all the best!
  Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
new article--possible role of inflammation in CRPS Annie Poo Reflex Sympathetic Dystrophy (RSD and CRPS) 1 11-29-2006 11:29 PM
new article--incidence of CRPS Annie Poo Reflex Sympathetic Dystrophy (RSD and CRPS) 0 11-27-2006 07:47 AM


All times are GMT -5. The time now is 02:59 AM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.