Hi Folks,
Do you think Prion's could be part of your RSD DX????
Their are several different strains, even though I have LYME they could very well be in the mix as well.
God Bless, Roz

Although cytokine production by activated glia precedes the apoptotic loss of hippocampal neurons in brains from scrapie-infected mice (47), the experiments presented here suggest that TNF-α and IL-6 alone do not play a critical role in the development of pathology in the CNS. Therefore, the apparent resistance of TNF-α−/− mice to i.p. challenge with scrapie could not be attributed to a role of TNF-α in the development of pathology in the CNS. Our experiments strongly suggest that the effects of TNF-α operate at a peripheral stage, prior to neuroinvasion.
http://www.pubmedcentral.nih.gov/art...i?artid=111835

http://www.microbiologybytes.com/virology/Prions.html

Hi Mates,

Even though I am in the States now, I still am English.
http://www.protomag.com/assets/in-pursuit-of-prions

Yes, I am 100% still out of pain. But I had to know why I got RSD, after my injury. The pain is just a SX of what what wrong with me. My nervious system was supposed to be protected, but it wasn't.

Much Love, Roz

Buckwheat,
I'm skimming what you have here, but is there any link between an increase in the incidence of RSD within populations most likely exposed to infectious prions (say, butchers or populations ingesting prion contaminated food)? Are there any autopsy findings indicating prion disease in those who have RSD as there are with CJD? Typically, these things are found and prion-related disease yields significant cognitive slowing over time which I haven't seen in the research with RSD, though I'm by no means any type of expert.
Lori Lee

Hi Lori Lee,

I hope these lines find you doing well. I am by no means saying I have this or anyone else. But in my case I have always known something broke the BBB.

The first 3 years I had just noticed the RSD in my PNS, a bit after the 3 year mark it went to my CNS. Around 5 years into RSD I noticed short term memory loss,with cognitive impairment as well. Maybe some others who have had RSD for over 5 years can share weather they have cognitive impairment, or short term memory loss??? I have lyme and Bartonella though, I also had to be treated for other parasite infections as well. Much Love, Roz

Hi Again,

No I could not find any autospy findings relating it to RSD thank goodness. But I could't find any relating it to Bartonella either.

I was raised pretty much a vegetarian, and still somewhat am. Hugs, Roz

Buckwheat, I reviewed the abstract on Pubmed that you supplied. All it really relates is that when you do an intraperitoneal injection of Scrapie (a disease that only affects mice and sheep, not humans) in immunodeficient (sick) mice, they lived longer than those with direct innoculation.

Can you please explain how a disease that does not make humans sick relates to human physiology, the difference and significance of the direct and indirect innoculation methodology and most importantly how all this could relate to CRPS in humans with normal immune systems (not mice or sheep)?

I am sorry, I am not getting it....

Dear Dubious,

I have to start with this article, focus on the IL 6 and TNF alpha.

The pathophysiology of CRPS is still a matter of debate. Afferent, efferent and central nervous system mechanisms are presumed. In artificially raised skin blisters in CRPS involved extremities, significantly higher levels of IL6 and TNF alpha were found. This is evidence for, in part, an inflammatory process. In another study significantly higher levels of tryptase in blister fluid of involved extremities were found; this demonstrates involvement of mast cells in the inflammatory process. In a case study describing one patient with an acute CRPS and another with a chronic CRPS, both patients received intravenous antiTNF. Both showed a clinical improvement and a decrease in cytokine levels in blister fluid. It is concluded that not only the nervous system but also the neuroimmune system is involved in the pathophysiology of CRPS.
http://www.rsdcanada.org/parc/englis...udies2005.html

Take notice of the neuroimmune system. Hugs, Roz