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Mike |
Thank you SO much for posting this article - I found it really interesting and am going to print it off and take it to my PM Doctor and see what he thinks and whether he can run any tests to check my B19.
When I was about 5, I had LOTS of small spots and rashes on my bottom and I had to go to the Doctors lots of times for them and they didn't know what they were and just kept giving me lots of cream. After about 6 months, they finally cleared up but I still have the scars from where they were! After reading on the internet about B19 Parvovirus, it said you most often get it when you are between the ages of 5 and 15 so that would make a lot of sense if it was that and is something to look into!!! I'm interested to know though why 100% of CRPS Type 2 patients tested positive for Parvovirus whilst only 70 something % tested positive in type 1 CRPS - were they mis-diagnosed or is everyone different??? I'm going to be interested in following this news. I recently participated in a Research Study provided by RSDSA where you had to give a DNA sample (spit into a container), fill in an online survey and then send it back off so maybe they were testing for this also - who knows! Thanks again for posting! |
Interesting Mike. Great job! While HPV B19 no doubt enters into the equation in some capacity, I am not sure that it enters into the causative side rather that in some way, it is simply a side effect of CRPS.
Seropositive existence of HPV B19 increases with age. By the age of 15, about 50% of individuals have serologic evidence of a past infection, which may present as the common childhood disease erythema infectiosum. At the age of 70, seroprevalence reaches 80 to 100%. This is according to a paper: Human parvovirus B19: relevance in internal medicine. Van Elsacker-Niele AM, Kroes AC. And Sève P, Ferry T, Charhon A, Calvet A, Broussolle C, in a paper titled Systemic manifestations of Parvovirus B19 infections, found that "B19 infection associated with virus clearance suggesting that B19 can act as a trigger of systemic disease. However, studies in large series indicate that in fact B19 is probably an extremely rare cause..." And then Van de Vusse AC, Goossens VJ, Kemler MA, Weber WE. found in their study entitled Screening of patients with complex regional pain syndrome for antecedent infections, that "seroprevalence in lower extremity CRPS 1 (94%) was significantly higher than in upper extremity CRPS I patients (68%)." Why would there be such a huge difference in seroprevelance simply by virtue simply of location of symptoms? And that would also then mean that HPV B19 was not present at all in the blood of 32% of the patients with upper extremity CRPS I. The B19 DNA seems to also cross over to many, many other illnesses like aplastic crisis in chronic haemolytic anaemias, exanthemathous disease and arthropathy, mainly in women, and chronic anaemia in the immunocompromised host. Even heart disease as discovered by Schenk T, Enders M, Pollak S, Hahn R, Huzly D, High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilative cardiomyopathy, which stated that "B19 DNA was found in myocardial samples from 46 of 48 seropositive and in none of 21 seronegative individuals." I think Gross et. al. may have it right in their abstract when they "suggest the involvement of parvovirus B19.......in the pathogenesis of CRPS." Perhaps there exists some defect or attack on the immune system to where HPV B19 then becomes a key player? Much like Pneumocystis carinii/jirovecii pneumonia is a very rare infection in people with normal immune systems but can become deadly in the immunocompromised. Very interesting paper though. Thanks for sharing! |
This is a fantastic article on Bacteria and viral infections relating to Neuro. Diseases
http://www.immed.org/NeuroDiseases/n...dicine0508.pdf Dear Mike, Could you please show me some research where it might not relate to RSD Type 2? It took getting out of pain to realize how very ill I was. I still have Neuro. problems and am still in treatment. On a serious note, if I went to a Neuro. MD I would most likely get DX with MS now. Remember Andi, I really believe if she would of had the right MD her life could of been spared. Much Love, Roz |
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The Gross article at the top of the thread showed a statistically significant relationship between parovoviris B19 and CRPS-1 (p< .01) in addition to the overwhelming finding with respect to CRPS-2. I'll email you a copy. I am unaware of any other studies thus far linking parovoviris B19 or for that matter any other infectious agent with CRPS, to a level of statistical significance. However, time will tell. Thank you for posting the survey piece by Garth L. Nicolson, it was interesting. One thing I didn't understand initially was the discussion of his prior article "High frequency of systemic mycoplasmal infections in Gulf War veterans and civilians with amyotrophic lateral sclerosis (ALS)," Nicolson GL, Berns P, Nasralla M, et al., J Clin Neurosci. 2002; 9: 525–529, where he reviews the information about how the ALS patients coming back from the Gulf War were all poisitive for mycoplasmal infections, but didn't reference a comparision with a control population. But I looked up the abstract on PubMed, and there it was: The presence of systemic mycoplasmal infections in the blood of Gulf War veterans (n=8) and civilians (n=28) with Amyotrophic Lateral Sclerosis (ALS) and age matched controls (n=70) was investigated by detecting mycoplasma gene sequences with forensic Polymerase Chain Reaction (PCR) and back hybridization with a radiolabeled internal oligonucleotide probe. Almost all ALS patients (30/36 or approximately 83%) showed evidence of Mycoplasma species in blood samples, whereas <9% of controls had blood mycoplasmal infections (P<0.001). Using PCR ALS patients with a positive test for any mycoplasmal infection were investigated for the presence of M. fermentans, M. pneumoniae, M. hominis and M. penetrans in their blood. All Gulf War veterans with ALS were positive for M. fermentans, except one that was positive for M. genitalium. In contrast, the 22/28 civilians with detectable mycoplasmal infections had M. fermentans (13/22, 59%) as well as other Mycoplasama species in their blood, and two of the civilian ALS patients had multiple mycoplasma species (M. fermentans plus M. hominis). Of the few control patients that were positive, only two patients (2/70, 2.8%) were positive for M. fermentans (P<0.001). The results support the suggestion that infectious agents may play a role in the pathogenesis and/or progression of ALS, or alternatively ALS patients are extremely susceptible to systemic mycoplasmal infections.Thanks again for posting this. Mike ps Hardly a day goes by that I don't think about Andi, but I won't get started on that now. :icon_cry: |
Mike, I find this article very interesting. I was diagnosed with this at some point. I am now trying to remember if it was before of after I had the surgery that led to my RSD. I always wondered if it was tied to the fact that I had Scarlet fever with a 107 degree tempertaure as a child. Or if it had something to do with my dog needing to be put down two days before that surgery from an undiagnosed auto-immune disorder. I also crushed the hand that was operated on 18 years ago. But I have always believed there was more too this than just that. Maybe someday we will know for sure.
Thanks, Denny |
Parvovirus
I am looking for some answers myself, as I contracted Parvo June 2012, rash came out July 2012, and I have suffered from two major spinal surgeries and severe joint pain, now having to go see a rheumatologist. Any help and research is greatly appreciated.
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I've only come across this thread today after melissa's post...but it's very interesting and I am wondering what people think about it in relation to IVIg as a treatment for CRPS? More and more, CRPS seems to be linked to auto-immune system failings, and having coeliac disease myself and arthritis, it's easy to think that perhaps my immune system is just cruddy. I also had glandular fever as a young woman, and was very poorly for nearly 2 years.
Any thoughts? Bram. |
Melissa,
Sorry that it has taken me this long to respond. Apparently I''m easily confused these days and sent a PM to someone else, thinking it was you :o. They have responded and now it is all sorted out. I too have been diagnosed with Parvo; and have been dealing with the joint symptoms for the past 4 months. The docs are looking into using IVIG as a therapy to help the body get over the virus. Have you had any therapy suggestions? I posted a thread on the MS forum (was diagnosed over 30 years ago and have SPMS). http://neurotalk.psychcentral.com/thread200717.html With love, Erika |
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