Rationale for a trial of immunosuppressive therapy in acute schizophrenia.

jccgf · 01-25-2007, 08:24 PM

I ran across this new study on PubMed and thought someone might be interested~

Rationale for a trial of immunosuppressive therapy in acute schizophrenia.

Quote:

Schizophrenia is a debilitating, costly, socially disruptive, life-threatening disease in which available treatments are largely palliative and empirical, and produce significant short- and long-term side effects. Therefore, a strong case can made for exploring alternative treatments with a rational basis for use in this disease. Considerable evidence indicates that autoimmune processes may be involved in some forms of schizophrenia, including altered risk of certain autoimmune diseases in patients and their relatives, shared epidemiological features, and apparent involvement of genes known to influence the immune response repertoire. Attempts to provide direct evidence for autoimmune processes have proven elusive, possibly due to the technical difficulty inherent in accessing autoantibodies with high affinity for brain cell-surface receptors. In view of this impasse, we argue for a well-designed trial in schizophrenia of immunosuppressive therapy, which is now the mainstay of therapy for many autoimmune diseases. Analysis of disease states in which immunosuppression has been effectively used over many decades provides guidelines necessary for a meaningful trial.Molecular Psychiatry advance online publication, 23 January 2007; doi:10.1038/sj.mp.4001959.
PMID: 17245324
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum

Also might be of interest~

MEDSCAPE (must register, but it's free)
Schizophrenia Linked to Variety of Autoimmune Disorders March 2006

The gluten connection: the association between schizophrenia and celiac disease. PMID: 16423158 Feb 2006

Jaspar · 10-12-2008, 12:01 PM

Quote:

Rationale for a trial of immunosuppressive therapy in acute schizophrenia

Schizophrenia Linked to Variety of Autoimmune Disorders

The gluten connection: the association between schizophrenia and celiac disease.

"Will the real 'schizophrenia' please stand up?" If removing gluten can cause "complete remission" in some cases of "schizophrenia" why is that even called the same illness as ones that instead need hormones, or the ones that need vitamins, or the ones that are purely mitochondrial, or the ones that.....

Jaspar

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