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-   -   Posted in chronic pain also. Help! New pain meds making me sick! (https://www.neurotalk.org/spinal-disorders-and-back-pain/163718-posted-chronic-pain-help-pain-meds-sick.html)

Dr. Smith 01-25-2012 01:47 AM

Quote:

Originally Posted by joojee22 (Post 844837)
Although the gabapentin maybe making you feel funny, this is also true for the percocetts:

Quote:

Buprenorphine itself binds more strongly to receptors in the brain than do other opioids, making it more difficult for opioids (or opiates) to react when buprenorphine is in the system. The blockade effect also has the result of blocking endogenous endorphins from binding to receptors, which can lead to psychological alterations in mood and mental capacity. This can cause cognitive and memory deficiencies via blockade of the reward system, which is pertinent to memory formation and normal mental function.
What I get that says, which appears to have been considerably altered from the original:
http://en.wikipedia.org/wiki/Buprenorphine
is that the butrans would be the cause of cognitive and memory deficiencies by blocking the endogenous endorphins from binding to the receptors - not the percocet.

Oxycodone has some deliterious effects on some few patients, but generally with opioid-naive patients. More often it may have euphoric/calming effects, which wear off in time, (would be blocked by the butrans) and would not be likely with a patient who has taken percocet for a very long time.

The two 800 lb. gorillas in the room appear to be the butrans and/or gabapentin, and since the problematical effects seem to be abating, this (hopefully) won't be an issue for very much longer anyway.

Doc

cath1 01-25-2012 10:22 AM

Quote:

Originally Posted by Dr. Smith (Post 844885)
What I get that says, which appears to have been considerably altered from the original:
http://en.wikipedia.org/wiki/Buprenorphine
is that the butrans would be the cause of cognitive and memory deficiencies by blocking the endogenous endorphins from binding to the receptors - not the percocet.

Oxycodone has some deliterious effects on some few patients, but generally with opioid-naive patients. More often it may have euphoric/calming effects, which wear off in time, (would be blocked by the butrans) and would not be likely with a patient who has taken percocet for a very long time.

The two 800 lb. gorillas in the room appear to be the butrans and/or gabapentin, and since the problematical effects seem to be abating, this (hopefully) won't be an issue for very much longer anyway.

Doc

Hopefully the gorillas are on a stronger patch then I am!!! LOL :Thats-Funneh:

joojee22 01-25-2012 06:14 PM

Yeh, maybe I read that a little wrong.

hey not to steal anyones thread, but this seems to be a Butran thread.

Why would Butran cause dehydration?
I spoke with my physical therapist and she said that pain meds cause dehydration and I am thinking the headache is from the dehydration caused by the Butrans? Seems to be working since I started drinking more water no headache so far... sigh...

also having some heart palpitaions??

Thanks :)

Dr. Smith 01-26-2012 03:01 AM

Quote:

Originally Posted by joojee22 (Post 845107)
Why would Butran cause dehydration?
I spoke with my physical therapist and she said that pain meds cause dehydration and I am thinking the headache is from the dehydration caused by the Butrans? Seems to be working since I started drinking more water no headache so far...

I don't know that Butran, or pain meds, do necessarily cause dehydration. Some people get opioid-induced edema, which is retention of water. Dehydration or dry mouth (and headache) do come up as known side effects of many pain medications (including Butran), but the frequencies I've seen have been in the 5-10% range. Opioid pain medications do cause constipation, but from partial paralysis of the stomach, decreasing peristalsis, reducing digestive secretions, etc. Dehydration could certainly cause constipation, and drinking more water is advised to patients with opioid-induced constipation, but constipation doesn't necessarily mean dehydration.
http://www.medicalnewstoday.com/info...nstipation.php

Headaches from opioids usually fade within a few days as the body adjusts to the medication.

Palpitations are also a known side effect, but could also be more serious; I'd call your doctor about that.

Dehydration will cause a headache - that's pretty much what a hangover is.

Doc

joojee22 01-30-2012 06:32 PM

relief
 
I'd like to say that I got my headaches(migraines) to calm down by not only drinking gatorade (sugar free) but I added MILK.

I'm not exactly sure why the milk works, but I believe it stimulates the liver to release it's toxin's.

Anyway, thought I would mention it in case anyone else is having the same issue.

They also added gabapentin to my regime today.. argh..

J.

Dr. Smith 01-30-2012 09:02 PM

Quote:

Originally Posted by joojee22 (Post 846595)
I'd like to say that I got my headaches(migraines) to calm down by not only drinking gatorade (sugar free) but I added MILK.

I'm not exactly sure why the milk works, but I believe it stimulates the liver to release it's toxin's.

I've never heard that; have you got anything (sites) on it? Milk thistle, yes, but milk - no.

Gatorade, I get - electrolytes. Milk is often named as a trigger/causal effect of migraine, but it's also mentioned as both abortive and prophylactic due to its calcium content.

These could both be clues if you get migraines other times.

Doc

cath1 01-31-2012 11:06 AM

Quote:

Originally Posted by joojee22 (Post 846595)
I'd like to say that I got my headaches(migraines) to calm down by not only drinking gatorade (sugar free) but I added MILK.

I'm not exactly sure why the milk works, but I believe it stimulates the liver to release it's toxin's.

Anyway, thought I would mention it in case anyone else is having the same issue.

They also added gabapentin to my regime today.. argh..

J.

I've been getting daily headaches from the patch (or gabapenten?) too. Some are closento migraine level.

I've been using accupuncture and resting more, coping with them. I just try to drink as much water as possible. Some days are better then others.

Good luck to us both!

joojee22 01-31-2012 03:11 PM

I will try taking calcium and see if that does anything... I couldnt find any literature about it, just a random post and i remembered something about drinking milk with LSD from way way back when (i'm older)... lol..

Cath1 - I would be very interested in your results if you try drinking milk?

Dr. Smith 01-31-2012 07:38 PM

Quote:

Originally Posted by joojee22 (Post 846922)
I will try taking calcium and see if that does anything...

Google: migraine calcium

You'll find articles on both sides; some recommending calcium (and/or magnesium) and some on calcium channel blockers, which supports calcium being both cause/trigger and/or abortive/prophylactic, depending on the individual.
Quote:

I couldnt find any literature about it, just a random post
SMACK! :Doh:

Doc

cath1 01-31-2012 08:48 PM

Quote:

Originally Posted by joojee22 (Post 846922)
I will try taking calcium and see if that does anything... I couldnt find any literature about it, just a random post and i remembered something about drinking milk with LSD from way way back when (i'm older)... lol..

Cath1 - I would be very interested in your results if you try drinking milk?

I have milk everyday and still have a headache. I'm also on a whack of supplements and take extra calcium. Doesn't help my headaches though. :(

I will bring it up at my next drs appointment and seebif he has any advice to offer. I also find I'm very tired and foggy (which I dont like) haven't decided if I'm going keep sticking with it. Not sure what is worse, pain or side effects of drugs?

Cathie


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