[boytos]

Mu receptor agonists are minimally effective in controlling the chronic pain of TOS, producing a generalized numbness, but little amelioration of the more intense symptoms. This is characteristic of neuropathic/neurogenic disorders [16]. Interestingly, nalbuphine, a kappa and sigma agonist, is consistently more effective and has minimal side effects.


Octreotide, a somatostatin analog which quickly down regulates neuropeptide production (SubP, CGRP, VIP, etc.}, is effective during early flare-ups, corroborating the importance of neurogenic peptides in initiating symptoms [17]. Octreotide labeled positron emission tomography is a potential diagnostic method because of its ability to image localized neurogenic inflammation.

Topical nitroglycerin can lessen pain significantly, more so than opiates. This points to the importance of endothelial factors that are nitric oxide mediated as well as the importance of vascular integrity [18].


Substantiating the importance of TNF-alpha, a major cytokine of mast cells, Etanercept, a TNF-alpha blocker, eliminates the diffuse and spreading pain accompanying flare ups (personal communication) [19].

More dramatically, low-dose heparin produces relief, lasting weeks to months. Heparin is a complicated mix of glycose aminoglycans with pleiotropic functions

http://www.doctorellis.com/TOS_neurogenic.html

[boytos]

If it right, maybe one day we will never broke some bones/muscles and pray it do the trick when a problem occure

[boytos]

Mu receptor agonists are minimally effective in controlling the chronic pain of TOS, producing a generalized numbness, but little amelioration of the more intense symptoms. This is characteristic of neuropathic/neurogenic disorders [16]. Interestingly, nalbuphine, a kappa and sigma agonist, is consistently more effective and has minimal side effects.

[Jomar]

Originally Posted by boytos

http://www.doctorellis.com/TOS_neurogenic.html

Thanks for posting doctor ellis's site - www.doctorellis.com - I haven't read it for yrs.
Thet linked article has some interesting info - I had to reread it a few times for it to sink in due to all the medical/scientific wording.

[boytos]

if it's inflammation maybe immobilization can be useful
more :

http://www.nutritionalwellness.com/a.../11_seaman.php


*added by Jo*mar*
The linked site has a poor safety rating per WOT {web of trust} so may be OK but might not be OK - FYI

[boytos]

autre :

http://www.doctorellis.com/Lecture.html
www.doctorellis.com/ClinicalFindings.pdf

[tied]

heparin is a blood thinner and how it works on tos is to thin the blood so it can more easily get through a narrower gap in the brachial plexus. they have also prescribed plavix and aspirin for me. be careful as if you get an injury you won't clot so easily. it also causes a lot of bruising for those minor bumps that come with living.

[boytos]

The document say :

Only 3% of the heparin functional sites are dedicated to anticoagulation. The rest regulate the extracellular matrix, cytokines, chemokines, growth factors, normalize the endothelium, leukocyte migration, cellular junctions, and stabilize mast cells. Its tissue half life in the extracellular matrix is on the order of several weeks [20]. Heparin has been shown to reduce: post-radiation neuropathy, inflammation and pain in severe burns, asthmatic bronchoconstriction, the symptoms of irritable bowel syndrome, and the pain of nerve entrapments by its direct action on peripheral nerves

[boytos]

what do you think about it tied ?