Theory about TOS : http://www.doctorellis.com/TOS_neurogenic.html


potential efficacity : *** : maybe very good potential efficacity, ** : maybe potential good efficacity, * : maybe potential Little efficacity
Danger/side effect : !!! : dangerous !! : risk of medium side effect ! : just be careful



Vitamins that may help no regards on the mechanism (sometimes unknow mechanism) :

Capsaicin dermal patch: in non-diabetic peripheral neuropathic pain **!:
http://www.ncbi.nlm.nih.gov/pubmed/20836576


Turmeric and Gamma-linolenic acid (GLA) reduce inlammation pain *! :
http://www.ehow.com/how_2320046_use-...tion-pain.html


Gamma-linolenic acid *!:
http://www.healingchronicpain.org/co..._nutrition.asp


Bromelain ease pinched nerve pain ***!
" Bromelain, a complex enzyme of pineapple, is commonly used in Europe as an anti-inflammatory compound for many forms of musculoskeletal injury, arthritis, cramps, post-surgery and post-traumatic swelling"
http://ezinearticles.com/?Sciatic-Ne...in!&id=4709603


hight dose of omega3 help the pain of TOS ***!
http://www.ncbi.nlm.nih.gov/pubmed/20090445
http://www.futureofmedicine.ca/images/Clin_J_Pain.pdf
http://www.fmnetnews.com/basics-news-omega110.php



Anticytokine

This important inflammatory cytokine is at the start of the inflammatory cascade.

decrease cytokine by simple natural things :
Less stress
exercise
Meditation and Tai Chi
Lose weight
good sleep
Glutathione agents – that includes SAMe, methionine, Coenzyme Q10, alpha lipoic acid. See:
http://painmuse.org/?p=339
and enbrel drug like

N-acetylcysteine *!

N-acetylcysteine (NAC) is a well-known antioxidant that also helps regulate production of inflammatory cytokines. In one study, NAC modulated IL-6 production through an NF-kappa B mechanism (Shibanuma M et al 1994).


Plant extracts **!
A number of plant extracts have also been shown to decrease NF-kappa B, including stinging nettle extract (Riehemann K et al 1999); helenalin from arnica flowers (Lyss G et al 1997); a spiroketal compound found in chamomile and Plagius flosculosus (Calzado MA et al 2005); oleandrin from oleander (Manna SK et al 2000b); resveratrol from grapes and other fruits (Manna SK et al 2000a); 1’-acetoxychavicol acetate (ACA) from Languas galanga (Ichikawa H et al 2005); curcumin (Jobin C et al 1999); ergolide from Inula britannica (Whan HJ et al 2001); rocaglamides extracted from Aglaia (Baumann B et al 2002); and tetrandrine from Han-Fang Chi, a Chinese herb used to treat rheumatic disorders (Ho LJ et al 2004).


Fish oils. ***!

The inclusion of omega-3 fish oils in the diet has been shown to help with autoimmune and inflammatory diseases (Kelley DS 2001; Simopoulos SP 1999, 2002) by suppressing synthesis of TNF-alpha (Endres S et al 1989). Vitamin E and fish oil work together to decrease pro-inflammatory cytokines, including IL-6 and TNF-alpha, in mice (Venkatraman JT et al 1999a,b). Omega-3 fish oils have been useful in patients with a variety of inflammatory diseases, including rheumatoid arthritis and atherosclerosis (Simopoulos SP 1999). Studies in humans with rheumatoid arthritis suggest that fish oil and vitamin E decrease inflammation in humans (Tidow-Kebritchi S et al 2001). Moreover, fish oil supplementation has shown anti-inflammatory effects, including decreased use of anti-inflammatory drugs, for patients with a variety of other chronic inflammatory diseases (Simopoulos SP 2002).


infliximab ***!!!
infliximab treatment suggest that infliximab is effective for suppression of cytokine-mediated inflammation, but could not completely block local vasculitis.
http://www.wjgnet.com/1007-9327/13/2089.pdf
http://cat.inist.fr/?aModele=afficheN&cpsidt=21531802


calendula, elder, and pansy **!

http://www.springerlink.com/content/wq27842134rqh058/


pentoxifylline tendral **!

Numerous studies show that pentoxifylline (PTX) is a potent inhibitor of TNF-a, IL-1(b), IL-6, and other pro-inflammatory cytokines (Neuner et al. 1994; Noel et al. 2000; Pollice et al. 2001; Ventura et al. 2001). Similarly, studies also show that DHA fish oil suppresses these same cytokines (Das 2000; Yano et al. 2000). In people who have a chronic disease involving elevated levels of the inflammatory cytokines, the daily administration of 400-800 mg of PTX and/or 1000-2000 mg of DHA fish oil could be of enormous benefit.


Bosellia **!
http://www.suite101.com/blog/daisyel...s_inflammation


siromilus***!!!
http://www.ncbi.nlm.nih.gov/pubmed/20600616
http://fr.wikipedia.org/wiki/Sirolim....C3.A9sirables



Antifibrotic

In the neurogenic inflammation theory, post-operative pain works like tos.
Several therapeutic agents have been shown to inhibit fibrosis and improve regeneration after injury in skeletal muscle by antagonizing transforming growth factor-β1
info :
http://jap.physiology.org/cgi/conten...ract/102/2/755
http://d-scholarship.pitt.edu/1045/


pentoxifylline–tocopherol*!
It seem that pentoxifylline–tocopherol is useful for fibrosis specially radiotherapy fibrosis.
http://bjr.birjournals.org/cgi/content/full/77/922/885
http://jco.ascopubs.org/content/21/13/2545.full


DuraSeal Xact***!
Prevent scar tissue
DSX for fibrosis prevention shows promising results in terms of safety, reduction of postoperative pain and functional results when compared to control with the additional advantage of being suitable for use in the presence of a dural tear.
http://www.biomedsearch.com/nih/Redu.../20542472.html


Using decorin, an anti-fibrosis agent, to improve muscle recovery after injury ***(!?)
De-activating TGF-beta (fibrosi)
Fortunately, researchers at the University of Pittsburgh have been working hard to develop ways to control fibrosis. The Pittsburgh scientists realised that fibrosis is stimulated by the overproduction of a chemical called transforming growth factor-beta (TGF-beta). TGF-beta is produced by tissues in response to injury and disease and is the major cause of fibrosis in humans and other animals.
The Pittsburgh researchers also knew that decorin - a proteoglycan (a protein with sugar attached) naturally found in the human body - has the ability to de-activate TGF-beta. Decorin has been shown to inhibit fibrosis in the kidney, liver, and lung, so why - the Pennsylvania scientists reasoned - would it not also stop fibres from taking over muscle tissue?
In recent research, the Pittsburgh medical team has in fact been able to show that decorin is a powerful anti-fibrotic agent in muscle tissue - and thus that decorin administration has the potential to be an outstandingly effective treatment for muscle injury (Kazumasa, F. et al., 'The Use of An Antifibrosis Agent to Improve Muscle Recovery after Laceration,' The American Journal of Sports Medicine, Vol. 29 (4), pp. 394-402, 2001).
These results suggest that decorin not only prevents fibrosis but also improves muscle regeneration and repair.
http://www.sportsinjurybulletin.com/archive/decorin.htm
http://ajsm.highwire.org/content/29/4/394.abstract
http://www.nature.com/mt/journal/v15.../6300250a.html


relaxin ***(!?)
Administration of relaxin can significantly improve skeletal muscle healing.
http://ajsm.highwire.org/content/33/12/1816.abstract


Suramin***!!
Intramuscular injection of suramin after a contusion injury improved overall skeletal muscle healing
http://ajsm.highwire.org/content/36/12/2354.abstract
http://www.jaaos.org/cgi/content/abstract/16/2/68
http://en.wikipedia.org/wiki/Suramin


angiotensin II***!
By modulating the response to local and systemic angiotensin II, angiotensin receptor blocker therapy significantly reduced fibrosis and led to an increase in the number of regenerating myofibers in acutely injured skeletal muscle
Angiotensin receptor blockers may provide a safe, clinically available treatment for improving healing after skeletal muscle injury.
http://ajsm.highwire.org/content/36/8/1548.abstract
http://en.wikipedia.org/wiki/Losartan

**

For those who are intersted :

http://thejns.org/doi/pdf/10.3171/SPI/2008/8/4/347
http://www.doctorellis.com/Lecture.html
http://ves.sagepub.com/content/40/3/251.full.pdf

goodbye