INTRODUCTION

Try to fight against the real cause of TOS

Before starting, read this to understand next steps :

Traumatic TOS (rsi ou accident) : explanation based on docter ellis's work :

http://www.doctorellis.com/TOS_neurogenic.html
http://thejns.org/doi/pdf/10.3171/SPI/2008/8/4/347
http://www.doctorellis.com/Lecture.html

So : Trauma -> inflammation spread on the nerve system -> de-differentiation (degeneration so the nerve become immature).

Facts : Regular heparin injection dramatically reduce symptomes but with reccurence

Regular epo injection dramatically reduce symptomes without reccurence


POSSIBLE TREATMENTS

From the most natural drugs to the most "dangerous", but all this stuff is way more safer than surgery

Potential efficacity : *** : maybe very good potential efficacity, ** : maybe potential good efficacity, * : maybe potential Little efficacity
Danger/side effect : !!! : dangerous !! : risk of medium side effect ! : just be careful


Part I - Anticytokine therapy : less inflammation, less pain and more regeneration

These important pro-inflammatory substance called cytokines (tnfa, nkbba) are at the start of the inflammatory cascade. Pro-inflammatory Cytokine reduce neuronal regeneration and exarcerb symptoms. So we must reduce first pro-inflammatory cytokines for less pain and more regeneration because nerve eletricity (pain) and inflammation reduce this regeneration.

General recommendations : Less stress, more exercice, less sugar and more sleep :-)


hight dose of omega3 is safe and reduce the pain of TOS ***!

(Natural omega3 si safer than synthetic : see the last link)
The inclusion of omega-3 fish oils in the diet has been shown to help with autoimmune and inflammatory diseases (Kelley DS 2001; Simopoulos SP 1999, 2002) by suppressing synthesis of TNF-alpha (Endres S et al 1989). Vitamin E and fish oil work together to decrease pro-inflammatory cytokines, including IL-6 and TNF-alpha, in mice (Venkatraman JT et al 1999a,b). Omega-3 fish oils have been useful in patients with a variety of inflammatory diseases, including rheumatoid arthritis and atherosclerosis (Simopoulos SP 1999). Studies in humans with rheumatoid arthritis suggest that fish oil and vitamin E decrease inflammation in humans (Tidow-Kebritchi S et al 2001). Moreover, fish oil supplementation has shown anti-inflammatory effects, including decreased use of anti-inflammatory drugs, for patients with a variety of other chronic inflammatory diseases (Simopoulos SP 2002).

http://www.ncbi.nlm.nih.gov/pubmed/20090445
http://www.futureofmedicine.ca/images/Clin_J_Pain.pdf
http://www.fmnetnews.com/basics-news-omega110.php
http://en.wikipedia.org/wiki/Omega-3_fatty_acid#Fish


Nicotinamide (vitamin B3) *!

Find in beef liver, brewer's yeast, broccoli
These findings demonstrate that nicotinamide has a potent immunomodulatory effect in vitro, and may have great potential for treatment of human inflammatory disease.
http://www.ncbi.nlm.nih.gov/pubmed/12519385
http://www.ncbi.nlm.nih.gov/pubmed/10331648


Bromelain ease pinched nerve pain ***!

"Bromelain, a complex enzyme of pineapple, is commonly used in Europe as an anti-inflammatory compound for many forms of musculoskeletal injury, arthritis, cramps, post-surgery and post-traumatic swelling (so neurogenic inflammation)"
http://ezinearticles.com/?Sciatic-Ne...in!&id=4709603


Turmeric reduce inflammation pain *! :
Anti inflammation drug that work on nerve pain.
http://www.ehow.com/how_2320046_use-...tion-pain.html


N-acetylcysteine *!

N-acetylcysteine (NAC) is a well-known antioxidant that also helps regulate production of inflammatory cytokines. In one study, NAC modulated IL-6 production through an NF-kappa B mechanism (Shibanuma M et al 1994). Its is very safe

http://www.ncbi.nlm.nih.gov/pubmed/19555676


Plant extracts **!

A number of plant extracts have also been shown to decrease NF-kappa B, including stinging nettle extract (Riehemann K et al 1999); helenalin from arnica flowers (Lyss G et al 1997); a spiroketal compound found in chamomile and Plagius flosculosus (Calzado MA et al 2005); oleandrin from oleander (Manna SK et al 2000b); resveratrol from grapes and other fruits (Manna SK et al 2000a); 1’-acetoxychavicol acetate (ACA) from Languas galanga (Ichikawa H et al 2005); curcumin (Jobin C et al 1999); ergolide from Inula britannica (Whan HJ et al 2001); rocaglamides extracted from Aglaia (Baumann B et al 2002); and tetrandrine from Han-Fang Chi, a Chinese herb used to treat rheumatic disorders (Ho LJ et al 2004). Try to find some and add it to your diet


Gamma-linolenic acid *!:

In Borage Oil, Black Currant Press, Evening Primrose.
A number of studies have suggested that it reduces inflammation and produces improvement in patients with rheumatoid arthritis and on nerve conduction velocity. This can realy help on the long run
http://cat.inist.fr/?aModele=afficheN&cpsidt=1935371
http://www.healingchronicpain.org/co..._nutrition.asp


Boswellia **!

http://www.suite101.com/blog/daisyel...s_inflammation
http://www.ncbi.nlm.nih.gov/pubmed/19943332


calendula, elder, and pansy **!

http://www.springerlink.com/content/wq27842134rqh058/


infliximab ***!!!

infliximab treatment suggest that infliximab is effective for suppression of cytokine-mediated inflammation, but could not completely block local vasculitis. Maybe too many side effect
http://www.wjgnet.com/1007-9327/13/2089.pdf
http://cat.inist.fr/?aModele=afficheN&cpsidt=21531802


siromilus ***!!!
Many side effect
http://www.ncbi.nlm.nih.gov/pubmed/20600616
http://fr.wikipedia.org/wiki/Sirolim....C3.A9sirables
http://www.ncbi.nlm.nih.gov/pubmed/20600616



Part II - Antifibrotic - scar tissue

Fibrosis and scar tissue reduce neuronal regeneration too
Several therapeutic agents have been shown to inhibit fibrosis and improve regeneration after injury in skeletal muscle by antagonizing transforming growth factor tnfa

info on fibrosis :
http://jap.physiology.org/cgi/conten...ract/102/2/755
http://d-scholarship.pitt.edu/1045/


Withanolide compounds **!
Withanolide compounds as inhibitors of fibrosis and identification of molecular targets for anti-fibrotic drug development

http://www.freshpatents.com/Withanol...0080032958.php


pentoxifylline–tocopherol(vitamine E)*!
It seem that pentoxifylline–tocopherol is useful for fibrosis specially radiotherapy fibrosis.
http://bjr.birjournals.org/cgi/content/full/77/922/885
http://jco.ascopubs.org/content/21/13/2545.full


Using decorin, an anti-fibrosis agent, to improve muscle recovery after injury ***(!?)
De-activating TGF-beta (fibrosi)
Fortunately, researchers at the University of Pittsburgh have been working hard to develop ways to control fibrosis. The Pittsburgh scientists realised that fibrosis is stimulated by the overproduction of a chemical called transforming growth factor-beta (TGF-beta). TGF-beta is produced by tissues in response to injury and disease and is the major cause of fibrosis in humans and other animals.
The Pittsburgh researchers also knew that decorin - a proteoglycan (a protein with sugar attached) naturally found in the human body - has the ability to de-activate TGF-beta. Decorin has been shown to inhibit fibrosis in the kidney, liver, and lung, so why - the Pennsylvania scientists reasoned - would it not also stop fibres from taking over muscle tissue?
In recent research, the Pittsburgh medical team has in fact been able to show that decorin is a powerful anti-fibrotic agent in muscle tissue - and thus that decorin administration has the potential to be an outstandingly effective treatment for muscle injury (Kazumasa, F. et al., 'The Use of An Antifibrosis Agent to Improve Muscle Recovery after Laceration,' The American Journal of Sports Medicine, Vol. 29 (4), pp. 394-402, 2001).
These results suggest that decorin not only prevents fibrosis but also improves muscle regeneration and repair.
http://www.sportsinjurybulletin.com/archive/decorin.htm
http://ajsm.highwire.org/content/29/4/394.abstract
http://www.nature.com/mt/journal/v15.../6300250a.html


relaxin ***(!?)

Administration of relaxin can significantly improve skeletal muscle healing.
http://ajsm.highwire.org/content/33/12/1816.abstract


DuraSeal Xact***!

Prevent scar tissue (at surgery )
DSX for fibrosis prevention shows promising results in terms of safety, reduction of postoperative pain and functional results when compared to control with the additional advantage of being suitable for use in the presence of a dural tear.
http://www.biomedsearch.com/nih/Redu.../20542472.html


angiotensin II ***!

By modulating the response to local and systemic angiotensin II, angiotensin receptor blocker therapy significantly reduced fibrosis and led to an increase in the number of regenerating myofibers in acutely injured skeletal muscle
Angiotensin receptor blockers may provide a safe, clinically available treatment for improving healing after skeletal muscle injury.
http://ajsm.highwire.org/content/36/8/1548.abstract
http://en.wikipedia.org/wiki/Losartan
http://onlinelibrary.wiley.com/doi/1.../hep.20425/pdf
http://www.jleukbio.org/cgi/content/full/78/1/195


Suramin***!!

Intramuscular injection of suramin after a contusion injury improved overall skeletal muscle healing
http://ajsm.highwire.org/content/36/12/2354.abstract
http://www.jaaos.org/cgi/content/abstract/16/2/68
http://en.wikipedia.org/wiki/Suramin



Part III - Nerveregeneration

The best part : Tos seems to be a de-differentiation problem so here we go (it can take time but you can have permanent relief)


AAL : Alpha lipoid acid **!

Very safe popular drug enhance nerve regeneration !
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939615/


Centella asiatica ethanolic extract **!

Study indicates components in CA ethanolic extract may be beneficial for accelerating repair of damaged neurons.
In many study, centella extract in the drinking water hastened recovery after nerve damage, with increased axonal regeneration and accelerated functional recovery.
Scar Management: Oral and topical use have reported benefits on wound and scar management with relief of symptoms, disappeance of inflammation and hastening of scar maturity.

http://www.ncbi.nlm.nih.gov/pubmed/16105244
http://cat.inist.fr/?aModele=afficheN&cpsidt=17082906
http://www.freepatentsonline.com/y2007/0196522.html
http://onlinelibrary.wiley.com/doi/1....0018/abstract

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816466/ ))) anti allergic


Acetyl-L-carnitine ***!

Very safe, present in red meat
http://www.ncbi.nlm.nih.gov/pubmed/15616239
http://www.ncbi.nlm.nih.gov/pubmed/19664977
http://www.ncbi.nlm.nih.gov/pubmed/19664977
http://recoverydoctor.blogspot.com/2...ase-nerve.html
http://www.lef.org/magazine/mag2000/may00-cover2.html
http://naturalmedicinejournal.com/pd...G10_LR_ace.pdf
http://www.ncbi.nlm.nih.gov/pubmed/18598095
http://www.ncbi.nlm.nih.gov/pubmed/17696591
http://www.ncbi.nlm.nih.gov/pubmed/17696588
http://www.ncbi.nlm.nih.gov/pubmed/17696591

prégnénolone ***!

Classic hormone know for increaseing nerve regeneration !!
http://www.pnas.org/content/89/15/6790.full.pdf


Vitamine D2/D3 *!

Axons regeneration
But many people that post on boards with chronic pain issues are seeing low levels come back from testing, and improvement with D3 supplements. (D2 is less effective)
http://www.ncbi.nlm.nih.gov/pubmed/18986226
http://www.endfatigue.com/health_art...erve_pain.html

Lithium*!

Pretty safe
http://www.ncbi.nlm.nih.gov/pubmed/12506095
http://cat.inist.fr/?aModele=afficheN&cpsidt=21098420
http://www.freepatentsonline.com/y2006/0217368.html
http://www.ncbi.nlm.nih.gov/pubmed/12506095


methylcobalamin *!

B12 like
Methylcobalamin is important because it is delivered more efficiently to nerve tissues than regular B-12

http://www.ncbi.nlm.nih.gov/pubmed/20508297
http://www.sciencedirect.com/science...0&searchtype=a


Qichu Fujin Recipe* (!?)
http://www.ncbi.nlm.nih.gov/pubmed/19747441


EPO **!

The drug use on the first link of the topic

http://www.macmillan.org.uk/Cancerin...ropoietin.aspx
http://www.sciencedirect.com/science...5&searchtype=a
http://tan.sagepub.com/content/1/3/193.abstract


EXTRA

Serrapeptase (***?)!

Serrapeptase is a safe homornal drug and is usefull for carpal tunnel syndrome, so maybe for tos too !!

Serrapeptase clears out the inflammation and dead/scar tissue. By clearing this problem tissue, it enables the nerve signal to work unimpeded and possibly the body’s own healing system to replace it with healthy tissue.

Here a detail of the CTS study :


Here a study for CTS with Serrapeptase (same problem as TOS but only on wrist)

This study was planned to assess the response of Serrapeptase in
patients with carpal tunnel syndrome (CTS) ====> Same mechanism as TOS !!

Twenty patients with CTS were evaluated clinically. After baseline
electrophysiological studies, these patients were given serrapetase10
mg twice daily with initial short course of nimesulide. Clinical and
electrophysiological reassessment was done after 6 weeks.

Mean age was 43.9 years with male to female ratio of 1:2.33. Sixty
five percent cases showed significant clinical (13/20) improvement which
was supported by significant improvement in electrophysiological
parameters. Recurrence was reported in only four cases. No significant
side effect was observed. ===== > 9/20 were saved with no reccurence and the 4 case can try again + very rare side effect not like surgery !!

CONCLUSIONS: Serrapeptase™ therapy may proved to be a
useful alternative mode of conservative treatment. Larger study
may be further helpful to establish the role of Serrapeptas in CTS. Don't know how but it work !

http://www.ncbi.nlm.nih.gov/pubmed/11225219
http://neurotalk.psychcentral.com/thread135530.html

I always said that they should have pineapple eating contests instead of pies, I crave fresh pineapple. бросок мальчика you da best.

what ?

My weird sense of humor, boytos sounds russian to me so i translated it. ha ha. boy toss.

i just add this :

http://www.ncbi.nlm.nih.gov/pubmed/18550776

I have send email to some tos's specialist.

I add preogesterone is a muscle relaxant AND nerve differentiation !