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Thoracic Outlet Syndrome Thoracic Outlet Syndrome/Brachial Plexopathy. In Memory Of DeAnne Marie. |
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02-03-2011, 08:17 AM | #1 | ||
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TOS is : inflammation, fibrosis, reperfusion ishemia and disfunction neuronal probably by de-differentiation process, and hypertropy.
Treating the fibrosis by reversing it : Pentoxifylline 800mg tocopherol 1000mg / day for 3-24 months Treating neurogenic inflammation to ease pain and fibrosis reversing : Pentoxifylline 800mg and Cromoglicic acid (stabiliz mast cell) 600mg/day for 3-24 months Treating reperfusion ishemia : Pentoxifylline 800mg + tocopherol 1000mg + Cromoglicic acid (reduce calcium) for 3-24 months Treating neuronal disfunction : Pentoxifylline 800mg, progesterone or other agents eventually. Treating hypertrophy wich is know to be reversible : Theory 1 : inflammed nerve ending : Pentoxifylline and Cromoglicic acid Theory 2 : Excitable nerve C fibers caused by inflammation loop : Cromoglicic acid Theory 3 : Fibrosis of scalene make positional muscles in tension : Pentoxifylline + tocopherol Pentoxifylline 800mg + tocopherol 1000mg + Cromoglicic acid for 3-24 months. I am actually on Pentoxifylline 800mg + tocopherol since 1 months and 20 days. Here my full explanations : http://neurotalk.psychcentral.com/thread142171.html http://neurotalk.psychcentral.com/thread143979.html |
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02-11-2011, 12:27 PM | #2 | ||
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Seriously listen to me ....
TOS is sometimes named brachial plexus neuritis because of his autoimmune inflammation. Here a study of PTX suppressing autoimmune neuritis : http://www.ncbi.nlm.nih.gov/pubmed/8981293 "Peripheral neuropathy may be classified according to the number of nerves affected or the type of nerve cell affected (motor, sensory, autonomic), or the process affecting the nerves (e.g. inflammation in neuritis)." Doctor ellis's proof are clear i think PTX work for carpal tunnel here : "In these patients 166 CTS were diagnosed of which 144 improved after the treatment, while the condition remained unchanged in 11 and even worsened in another 11 cases. Using the clinical and EMG criteria the findings were divided to mild, moderate and severe CTS. 77 mild CTS improved by 61% in average, 63 moderate CTS were improved by 47% and 26 of severe CTS improved by 50%." http://www.ncbi.nlm.nih.gov/pubmed/10659375 Infos : The vasa vasorum/vasa nervorum is probably the origin of TOS, along with ishemia reperfusion. Acute ischemic lesions of the peripheral nerves can be reversible but severe and prolonged ischemic process of the nerves can lead to extensive axon injury along with Wallerian degeneration (19). The severity of these lesions depends on the duration and the intensity of ischaemia and compression. Vasa nervorum can also be affected by trauma, diabetes and by some metabolites. These factors can lead to ischemic neuropathy (20,21,22) and reperfusion injury during peripheral nerve injury (23). Ischaemia leads an insufficient ATP supply when ATP consumption in all damaged tissues increase. Anaerobic metabolic process levels increase in such process and eventually hypoxanthine levels also increase in ischemic tissues. In the reperfusion phase of ischaemia superoxide radical levels and hydrogen peroxide levels increase. These can lead to the damage of the tissues (18 ). Pentoxifylline had been used in some experimental and clinical studies especially to restore the normal function of the vasa vasorum. Last edited by boytos; 02-11-2011 at 12:44 PM. |
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02-11-2011, 01:07 PM | #3 | |||
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I wasn't sure what it was so I thought I'd post some of the info/sites I found.
Pentoxifylline info from drugs.com - http://www.drugs.com/search.php?sear...Pentoxifylline http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000846
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02-11-2011, 02:15 PM | #4 | ||
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Traction or compression may result in ischemia, which initially damages the vasa vasorum. Severe compression injuries can result in intraneural hematomas, which can compress adjacent nerve tissue.
http://emedicine.medscape.com/article/316888-overview |
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