[boytos]

http://en.wikipedia.org/wiki/Flupirtine

http://www.ncbi.nlm.nih.gov/pmc/arti...0/?tool=pubmed

+ Muscle relaxant and Analgesic action on neuropathic pain
+ No addictive effect
+ Not a nsaid/steroid/opiod
+ Safe 90% of the times

- Can sometimes have serious liver toxicity

[nukenurse]

Thanks BOYTOS

From the article:

The expression of Bcl-2, an antiapoptotic agent, and glutathione, a scavenger of reactive oxygen, are reduced during glutamate or NMDA-induced apoptosis in cells. Flupirtine is found to increase the levels of Bcl-2 and glutathione

This is why I take glutathione supplements. You can buy them at any nutrition store. I buy the reduced form from Jarrow.

Apoptosis, a programmed cell death, is caused by increased intracellular Ca++ levels, mitochondrial dysfunction, cell membrane disruption

That is why I take pqq as a supplement. 10mg works for me. Again, this supplement can be bought at a nutrition store. There are also studies that show that peripheral nerve injuries result in mitochondrial problems and can result in excessive ROS (reactive oxygen species) production. Glutathione is helpful against ROS as well.

[boytos]

Yes, but ros inhibition alone is rapidly limited, unfortunaly.

Pqq is probably good for global health, the "sens fundation" think it can significantly increase lifespan.

Other :

http://www.ncbi.nlm.nih.gov/pubmed/7684675

In comparison with opiate drugs, flupirtine appears to produce fewer central nervous system effects, no respiratory or cardiovascular depression, and no overt tolerance or physical dependence on prolonged administration. If these initially favourable results are confirmed in larger long term trials, then flupirtine would appear to represent an effective analgesic for the relief of moderate pain, particularly that of musculoskeletal origin.

http://www.ncbi.nlm.nih.gov/pubmed/20433607

Flupirtine is an activator of Kv7 (KCNQ/M) potassium channels that has found clinical use as an analgesic with muscle relaxant properties

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024960/

We also discuss the potential of Kv channel openers as therapeutic agents for trigeminal neuropathic/inflammatory pain, such as mechanical allodynia.

It is likely, therefore, that activators of slow potassium (Kv7) channels may be beneficial for some forms of neuropathy, for example, neuropathic pain due to..

http://www.zmnh.uni-hamburg.de/zmnh/...sittl_2010.pdf