In general, the doc says you have to increase Methadone very slowly (over weeks) due to the build-up of the drug and the way it works (i.e. Anna Nicole and her son OD'd which is a risk when someone is just downing Methadone looking for a quick response, if that is what they did or not.)

Also, he said that with Methadone, unlike other pain drugs, that it can be raised with less side effects and give more long-term relief than other pain drugs.

As with any medication, we all are individual and can have differing reactions. I share this stuff only so that others can have some info. relating to TOS when they see their pain docs and have their own individual consults.