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Old 03-20-2014, 03:29 PM #101
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Book OT - Valacyclovir/Valtrex

Off Topic FYI

This first one is a single case study but it is a very interesting article despite the limitations and the financial disclosures of the doctor.

Quote:
Certain limitations need to be noted. This is a single case and may represent an epiphenomenon. The absence of a placebo control is inherent to single case studies. Lastly, a viral encephalopathy or even a viral infection was not definitively demonstrated in this case, although it bears close resemblance to a case series in which viral infection was definitively demonstrated.
Is Valacyclovir a Mood Stabilizer? Autism 3:118. doi:
Henderson TA (2013)
http://www.omicsgroup.org/journals/i....php?aid=19860

Quote:
The present case illustrates a dramatic improvement in symptoms normally associated with Bipolar Disorder, ADHD, and possibly Autism Spectrum Disorders with antiviral therapy. Taken together with previous work on the association between Herpes family viruses and depressive symptoms, further study of the proposed association between these viruses and neuropsychiatric symptoms is encouraged.
[open-access article distributed under the terms of the Creative Commons Attribution License]

Adv Mind Body Med. 2014 Winter;28(1):4-14.
Valacyclovir treatment of chronic fatigue in adolescents.
Henderson TA.
http://www.ncbi.nlm.nih.gov/pubmed/24445302
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Old 03-24-2014, 03:25 PM #102
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Default TBI - Adult onset Tics

http://www.ncbi.nlm.nih.gov/pubmed/21534741
Brain Inj. 2011;25(6):629-33. doi: 10.3109/02699052.2011.572944.
Tics after traumatic brain injury.
Ranjan N1, Nair KP, Romanoski C, Singh R, Venketswara G.
Abstract

http://informahealthcare.com/doi/abs...52.2011.572944
Full Text - Brain Injury, June 2011; 25(6): 629–633
Access has changed since this was first posted.
Full Text now pay per view.

_____________________

http://www.ncbi.nlm.nih.gov/pubmed/15867978
Rev Bras Psiquiatr. 2005 Mar;27(1):11-7. Epub 2005 Apr 18.
Secondary tics and tourettism.
Mejia NI1, Jankovic J.
Abstract

http://www.scielo.br/pdf/rbp/v27n1/23707.pdf
Revista Brasileira de Psiquiatria 2005;27:11–17
Secondary Tics and Tourettism
Nicte I Mejia, Joseph Jankovic
[head trauma]
Full Text

Last edited by Lara; 03-16-2015 at 06:03 PM. Reason: fixed broken link
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Old 04-20-2014, 04:55 PM #103
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Book Motor excitability during movement preparation - TS

from Nov, 2013
Note small number of participants -
9 male. one female.
several with co-morbids.
some medicated. some not.
Nonetheless, it's an interesting study.

http://onlinelibrary.wiley.com/doi/1...jnp.12033/full
Motor excitability during movement preparation in Tourette syndrome
Amelia Draper, Lucinda Jude, Georgina M. Jackson and Stephen R. Jackson,
Article first published online: 28 NOV 2013
DOI: 10.1111/jnp.12033

http://psychcentral.com/news/2013/12...ome/63922.html
Scientists Tie Brain Mechanism To Tics in Tourette Syndrome

http://www.nottingham.ac.uk/news/pre...rome-tics.aspx
Researchers uncover mechanism controlling Tourette Syndrome tics
Click on - Click here for full story
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Old 05-02-2014, 10:21 PM #104
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Book TS, OCD - Differences in genetic architecture

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive
Disorder Reveals Differences in Genetic Architecture


from PLOS Genetics

Published: October 24, 2013
DOI: 10.1371/journal.pgen.1003864

Quote:
The results also indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.
Note: "This is an open-access article, free of all copyright"
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Old 06-13-2014, 03:55 PM #105
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Default Impaired activation of innate immune response -

http://informahealthcare.com/doi/abs...75.2014.907503

World J Biol Psychiatry. 2014 Jun 9:1-6. [Epub ahead of print]
Impaired activation of the innate immune response to bacterial challenge in Tourette syndrome.
Weidinger E, Krause D, Wildenauer A, Meyer S, Gruber R, Schwarz MJ, Müller N.

[I haven't read full text yet, only this abstract. $46US for 23hrs seemed a little steep]
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Old 06-13-2014, 04:01 PM #106
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Default Febrile convulsions increase risk of TS

http://www.seizure-journal.com/artic...138-1/abstract
Seizure - European Journal of Epilepsy
Febrile convulsions increase risk of Tourette syndrome
Yi-Fang Tu, Cheng-Li Lin, Chih-Hao Lin, Chao-Chin Huang, Fung-Chang Sung, Chia-Huang Kaoemail
Published Online: May 19, 2014

_______________



Edited to add my comment -

I would wonder what type of illness or infection actually caused the febrile convulsions in the first place

Last edited by Lara; 06-13-2014 at 04:32 PM.
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Old 06-14-2014, 10:00 AM #107
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Default

Well I know strep infections can cause febrile convulsions as can other childhood viruses and bacterial infections....I wonder if what these researchers were finding was more related to PANS rather than TS?
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Old 06-14-2014, 08:33 PM #108
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Well that was sort of what I was thinking.
I'd love to read the full text when it is free, otherwise it is a bit of a puzzle.
My first thought was about the actual conditions that preceded the seizures in all of those patients to cause the fever in the first place.

Interesting too, is that there was another article on that same page suggesting that low iron and low serum ferritin may be risk factors for febrile seizures in children.

Association between iron status and febrile seizures in children
Soheila Zareifar, Hamid Reza Hosseinzadeh, Nader Cohan

http://neurotalk.psychcentral.com/post1041370-86.html
older articles re: ferritin, iron

anyway...

Last edited by Lara; 06-14-2014 at 10:49 PM. Reason: corrections and additions
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Old 06-10-2015, 12:44 AM #109
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J Am Acad Child Adolesc Psychiatry. 2015 Jun
Epub 2015 Mar 17.

PubMed Abstract

Maternal history of autoimmune disease and later development of tourette syndrome in offspring.


Dalsgaard S, Waltoft BL, Leckman JF, Mortensen PB.
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Old 06-10-2015, 12:54 AM #110
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PLoS One. 2015 Mar 20;
10(3):e0120499. doi: 10.1371/journal.pone.0120499.
eCollection 2015.

PubMed Abstract

Neuronal antibody biomarkers for Sydenham's chorea identify a new group of children with chronic recurrent episodic acute exacerbations of tic and obsessive compulsive symptoms following a streptococcal infection.


Harvey S. Singer , Adda Mascaro-Blanco, Kathy Alvarez, Christina Morris-Berry, Ivana Kawikova, Hilla Ben-Pazi,Carol B. Thompson, Syed F. Ali, Edward L. Kaplan, Madeleine W. Cunningham
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