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-   -   Articles, Abstracts and News Reports on TS (https://www.neurotalk.org/tourette-syndrome/16243-articles-abstracts-news-reports-ts.html)

Lara 01-12-2009 08:50 AM
Air swallowing as a tic
 
PubMed

J Psychosom Res. 2008 Nov;65(5):497-500. Epub 2008 Oct 1.
Air swallowing as a tic.
Weil RS, Cavanna AE, Willoughby JM, Robertson MM.

Institute of Neurology, Queen Square, London, UK.

Quote:
The authors present a patient with Gilles de la Tourette syndrome who developed abdominal distension and bloating due to air swallowing. We suggest that this air swallowing may have been due to a tic.

Chemar 01-15-2009 09:39 AM
NEJM Research Antipsychotics & Cardiac Risk
 
http://content.nejm.org/cgi/content/short/360/3/225

Quote:
Conclusions: Current users of typical and of atypical antipsychotic drugs had a similar, dose-related increased risk of sudden cardiac death.

Lara 03-18-2009 05:29 PM
Dopamine and Toxoplasmosis
 
From Bot's news -

Parasite may trigger schizophrenia

Quote:
The team found the parasite's genetic make-up included an enzyme that aids in the production of dopamine. "At this point the research is too premature to suggest changes in treatment" of schizophrenia, McConkey continued. Nonetheless, "Toxoplasmosis screening would be warranted in psychological analysis."
He and his colleagues now plan to explore the possible role of toxoplasma in other neurological diseases associated with dopamine, including autism, Parkinson's disease, and Tourette's syndrome.
A Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii
Elizabeth A. Gaskell, Judith E. Smith, John W. Pinney, Dave R. Westhead, and Glenn A. McConkey

from PubMed Central

PLoS ONE. 2009; 4(3): e4801.
Published online 2009 March 11. doi: 10.1371/journal.pone.0004801.

Lara 03-20-2009 09:35 AM
TS and comorbid PDDs
 
http://jcn.sagepub.com/cgi/content/abstract/24/2/170
Journal of Child Neurology, Vol. 24, No. 2, 170-175 (2009)
DOI: 10.1177/0883073808322666

Tourette Syndrome and Comorbid Pervasive Developmental Disorders
Larry Burd, Qing Li, Jacob Kerbeshian, Marilyn G. Klug, Roger D. Freeman

Quote:
We found 334 (4.6%; 1 of every 22 participants) with Tourette syndrome had a comorbid pervasive developmental disorder.
Quote:
Variables from logistic modeling that were significant predictors of Tourette syndrome and pervasive developmental disorders were: male gender; no family history of tics/Tourette syndrome; and an increased number of comorbidities (P < .001).
Quote:
We found rates of comorbid Tourette syndrome and pervasive developmental disorders to be increased by 13 times. Identification of differences between subgroups of patients with Tourette syndrome may increase understanding of syndromal susceptibility, severity, and outcome.
Note: this study involved the Tourette Syndrome International Database Consortium Registry.

Lara 04-21-2009 08:10 AM
PubMed Article

J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):13-23.Links
The behavioral spectrum of Gilles de la Tourette syndrome.
Cavanna AE, Servo S, Monaco F, Robertson MM.

Quote:
This paper provides an updated review of the literature on the multifaceted phenotype of Tourette's syndrome, with special attention to the behavioral problems and the relationship between Tourette's syndrome and comorbid neuropsychiatric conditions. The issue of whether Tourette's syndrome should still be considered as a unitary nosological entity is also addressed.

Lara 04-21-2009 08:13 AM
PubMed Article

Mov Disord. 2009 Apr 7
Immunopathogenic mechanisms in tourette syndrome: A critical review.
Martino D, Dale RC, Gilbert DL, Giovannoni G, Leckman JF.

Quote:
Tourette syndrome (TS) has a multifactorial etiology, in which genetic, environmental, immunological and hormonal factors interact to establish vulnerability
<snipped article>

Quote:
Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.

Lara 04-21-2009 08:17 AM
PubMed Article

J Neurol. 2009 Mar 14.
A preliminary study of the frequency of anti-basal ganglia antibodies and streptococcal infection in attention deficit/hyperactivity disorder.
Sanchez-Carpintero R, Albesa SA, Crespo N, Villoslada P, Narbona J.

Quote:
This preliminary study indicates that frequency of ABGA in children with nc-ADHD does not differ from that in matched controls, despite the fact that our ADHD patients had had more recent GABHS infections than the controls. This suggests that ABGA do not have a role in the pathogenesis of nc-ADHD.
Note: small number involved in study

Quote:
We compared 22 children with nc-ADHD (DSM-IV-TR) and 22 healthy controls matched by age, gender and season of sample collection, for the frequency of recent GABHS infection and the presence of ABGA.

Lara 05-22-2009 03:21 PM
Immunopathogenic mechanisms in tourette syndrome
 
http://neurotalk.psychcentral.com/post499139-46.html
I already posted this one but I'll leave it here and quote the material regarding T cells.

PubMed
Mov Disord. 2009 Apr 7.
Immunopathogenic mechanisms in tourette syndrome: A critical review.
Martino D, Dale RC, Gilbert DL, Giovannoni G, Leckman JF.

Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.

<snipped abstract>
Quote:
Finally, a general predisposition to autoimmune responses in TS patients is indicated by the reduced frequency of regulatory T cells, which induce tolerance towards self-antigens. Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.

Lara 05-22-2009 03:23 PM
Immunophenotyping in Tourette syndrome--a pilot study.
 
PubMed
Eur J Neurol. 2008 Jul;15(7):749-53. Epub 2008 May 15.
Immunophenotyping in Tourette syndrome--a pilot study.
Möller JC, Tackenberg B, Heinzel-Gutenbrunner M, Burmester R, Oertel WH, Bandmann O, Müller-Vahl KR.
Department of Neurology, Philipps-University, Marburg, Germany

Lara 05-22-2009 03:25 PM
Decreased numbers of regulatory T cells
 
PubMed
Biol Psychiatry. 2007 Feb 1;61(3):273-8. Epub 2006 Sep 25.
Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study.

Kawikova I, Leckman JF, Kronig H, Katsovich L, Bessen DE, Ghebremichael M, Bothwell AL.
Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut

<snipped article>
Quote:
CONCLUSIONS: These data support our hypothesis that at least some TS patients may have a decreased capacity to inhibit autoreactive lymphocytes through a deficit in T reg cells. Interactions of host T cell immunity and microbial factors may also contribute to the pathogenesis of TS.
http://linkinghub.elsevier.com/retri...06322306008043

Lara 05-22-2009 03:29 PM
Genomic profiles for human peripheral blood T cells, B cells etc...
 
PubMed

Genomics. 2006 Jun;87(6):693-703. Epub 2006 Mar 20
Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome.
Du X, Tang Y, Xu H, Lit L, Walker W, Ashwood P, Gregg JP, Sharp FR.
MIND Institute, University of California at Davis

Lara 05-22-2009 03:33 PM
OCD - Immunological alterations
 
old abstract - 1999

PubMed
Biol Psychiatry. 1999 Sep 15;46(6):810-4.
Immunological alterations in adult obsessive-compulsive disorder.

Marazziti D, Presta S, Pfanner C, Gemignani A, Rossi A, Sbrana S, Rocchi V, Ambrogi F, Cassano GB.

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy.

Quote:
CONCLUSIONS: These data indicate that patients with adult OCD showed increased CD8+, i.e., suppressor T lymphocytes, and decreased CD4+, which identify helper T lymphocytes, as compared with a similar group of healthy control subjects. The findings appear peculiar to patients with OCD and are suggestive of an immunologic imbalance, which might be related to the stress deriving from the frustrating situation determined by the disorder itself.
Then again...

PubMed
Psychiatry Res. 2001 Nov 30;104(3):221-5.
The use of antibody D8/17 to identify B cells in adults with obsessive-compulsive disorder.

Eisen JL, Leonard HL, Swedo SE, Price LH, Zabriskie JB, Chiang SY, Karitani M, Rasmussen SA.
Department of Psychiatry and Human Behavior, Butler Hospital, Brown University School of Medicine,

Quote:
Compared with healthy control subjects, individuals with childhood-onset obsessive-compulsive disorder (OCD) have been reported to have a higher percentage of B cells that react with the monoclonal antibody D8/17, a marker for rheumatic fever. This study sought to replicate these findings in adults with OCD. Double-blind analyses of blood samples from 29 consecutive adults with primary OCD and 26 healthy control subjects were conducted to determine the percentage of B cells identified by D8/17. Using a standard criterion of > or =12% labeled B cells to denote positivity, rates of D8/17 positive individuals did not significantly differ between the OCD (58.6%) and control (42.3%) groups. Early age of onset was not a predictor of D8/17 positivity in the OCD group. The percentage of B cells identified by the monoclonal antibody marker D8/17 did not distinguish adults with OCD from control subjects, nor did it distinguish a sub-group of adults with OCD who described pre-pubertal onset of their OCD symptoms.

Lara 05-22-2009 03:47 PM
Full Text of 2006 TS genome scan
 
PubMed Central Full Text Article

Am J Hum Genet. 2007 February; 80(2): 265–272.
Published online 2006 December 12.
PMCID: PMC1785345

Genome Scan for Tourette Disorder in Affected-Sibling-Pair and Multigenerational Families
The Tourette Syndrome Association International Consortium for Genetics

Lara 05-22-2009 04:16 PM
superantigen hypothesis
 
excerpt from Book...

Tourette's syndrome--tics, obsessions, compulsions
By James F. Leckman, Donald J. Cohen (1998)

from Google Books

Lara 05-22-2009 04:23 PM
Functional Disturbances Within Frontostriatal Circuits
 
PubMed
Am J Psychiatry. 2009 May 15.
Functional Disturbances Within Frontostriatal Circuits Across Multiple Childhood Psychopathologies.
Marsh R, Maia TV, Peterson BS.

<snipped abstract>
Quote:
Conclusions Analogous brain mechanisms in parallel frontostriatal circuits, or even in differing portions of the same frontostriatal circuit, may underlie the differing behavioral disturbances in these multiple disorders, although further research is needed to confirm this hypothesis
.

Lara 05-22-2009 04:26 PM
Prefrontal and anterior cingulate cortex abnormalities (VBM) (MTI)
 
Note: small sized study.

PubMed

BMC Neurosci. 2009 May 12;10(1):47.
Prefrontal and anterior cingulate cortex abnormalities in Tourette Syndrome: evidence from voxel-based morphometry and magnetization transfer imaging.
Muller-Vahl KR, Kaufmann J, Grosskreutz J, Dengler R, Emrich HM, Peschel T.

Lara 05-22-2009 04:32 PM
stimulus evaluation, response inhibition and motor processing
 
PubMed
Psychiatry Res. 2009 May 30;167(3):202-20.

Electrophysiological manifestations of stimulus evaluation, response inhibition and motor processing in Tourette syndrome patients.
Thibault G, O'Connor KP, Stip E, Lavoie ME.

Centre de Recherche Fernand-Seguin and Hôpital Louis-H. Lafontaine, Montréal, Québec, Canada; Département de Psychologie, Université de Montréal, Montréal, Québec, Canada.

Lara 05-22-2009 04:35 PM
Long needle acupuncture
 
PubMed

Zhongguo Zhen Jiu. 2009 Feb;29(2):115-8.Links
Clinical study on scalp acupuncture with long needle-retained duration for treatment of Tourette syndrome
[Article in Chinese]
Zhu BC, Shi-fen X, Shan YH.
Department of Acupuncture, Shanghai Hospital of TCM, Shanghai

Lara 05-22-2009 04:38 PM
The behavioral spectrum of Gilles de la Tourette syndrome.
 
PubMed

J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):13-23.
The behavioral spectrum of Gilles de la Tourette syndrome.
Cavanna AE, Servo S, Monaco F, Robertson MM.

Sobell Department of Movement Disorders, Institute of Neurology, London, UK.

<snipped abstract>

Quote:
This paper provides an updated review of the literature on the multifaceted phenotype of Tourette's syndrome, with special attention to the behavioral problems and the relationship between Tourette's syndrome and comorbid neuropsychiatric conditions. The issue of whether Tourette's syndrome should still be considered as a unitary nosological entity is also addressed.
NOTE: http://neuro.psychiatryonline.org/cg...stract/21/1/13
Full Text at a price

Lara 06-11-2009 08:10 AM
Stuttering (from my bookmarks)
 
http://www.ncbi.nlm.nih.gov/pubmed/10907717
J Commun Disord. 2000 May-Jun;33(3):227-39;
Dysfluency and phonic tics in Tourette syndrome: a case report.
Van Borsel J, Vanryckeghem M.

http://www.mnsu.edu/comdis/isad2/papers/molt2.html
The Basal Ganglia's Possible Role in Stuttering: An Examination of Similarities between Stuttering, Tourette Syndrome, Dystonia, and other Neurological-Based Disorders of Movement
by Larry Molt

http://www.mnsu.edu/comdis/isad6/papers/donaher6.html
Disfluency Associated with Tourette's Syndrome: Two Case Studies
by John Tetnowski and Joseph Donaher

http://www.stutteringhelp.org/Default.aspx?tabid=440
Stuttering and Tourette's Syndrome
This material was compiled by Luc De Nil, Ph.D., Chair of the
Graduate Department of Speech-Language Pathology, University of
Toronto, and by Paul Sandor, M.D., Director of the Tourette’s
Syndrome Clinic, University Health Network.

http://www.cmaj.ca/cgi/content/full/162/13/1849
Stuttering: an update for physicians
Daniel Costa and Robert Kroll

http://www.ncbi.nlm.nih.gov/pubmed/15856831
Rev Laryngol Otol Rhinol (Bord). 2004;125(5):297-301. Links
Stuttering and Tourette's syndrome: a short tutorial and account of a four years experience in a stuttering clinic constriction of the vocal tract
[Article in French]
Monfrais-Pfauwadel MC.
Hopital Europeen Georges Pompidou, AP-HP, Paris, France

Quote:
The author presents a short tutorial of Gilles de la Tourette's syndrome followed by a state of the art of review of the clinical links between stuttering and the different kinds of Tourette and tics disorders. The author relates her own experience of working for four consecutive years at the new stuttering diagnostic center at the "Hopital Europeen Georges Pompidou ". The article ends with a practical review of the actual therapies available when such a diagnosis is made.
http://www.mnsu.edu/comdis/isad6/pap...fauwadel6.html
Differential Diagnosis of Stuttering and Self-referral
by Marie-Claude Monfrais-Pfauwadel
from France

http://www.unboundmedicine.com/medli...t=10&prev=true

Lara 06-27-2009 06:53 PM
PubMed Abstract

Mol Psychiatry. 2009 Jun 23.
Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes.
Elia J, Gai X, Xie HM, Perin JC, Geiger E, Glessner JT, D'arcy M, Deberardinis R, Frackelton E, Kim C, Lantieri F, Muganga BM, Wang L, Takeda T, Rappaport EF, Grant SF, Berrettini W, Devoto M, Shaikh TH, Hakonarson H, White PS.

Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Quote:
Although no excess CNVs, either deletions or duplications, were found in the ADHD cohort relative to controls, the inherited rare CNV-associated gene set was significantly enriched for genes reported as candidates in studies of autism, schizophrenia and Tourette syndrome, including A2BP1, AUTS2, CNTNAP2 and IMMP2L.
___________

from Psych Central News
Gene Variations Linked to ADHD
By Psych Central News Editor
Reviewed by John M. Grohol, Psy.D. on June 25, 2009

Lara 01-22-2011 04:02 AM
Which Neurodevelopmental Disorders Get Researched and Why?

Bishop DV.

Developmental Neuropsychology, University of Oxford, Oxford, United Kingdom

Lara 05-21-2011 05:11 AM
Tics after TBI
 
PubMed Abstract

Brain Inj. 2011;25(6):629-33.
Tics after traumatic brain injury.
Ranjan N, Nair KP, Romanoski C, Singh R, Venketswara G.
Source

Sheffield Teaching Hospitals NHS Trust , Sheffield , UK.

Lara 05-21-2011 05:15 AM
PubMed Abstract

Mov Disord. 2011 Mar;26(4):735-8. doi: 10.1002/mds.23434. Epub 2010 Nov 10.
Clinical correlates of quality of life in Tourette syndrome.

Eddy CM, Cavanna AE, Gulisano M, Agodi A, Barchitta M, Calì P, Robertson MM, Rizzo R.

Source

Department of Neuropsychiatry, The Barberry National Centre for Mental Health, Birmingham, United Kingdom.

Abstract

<snip>
Quote:
Symptoms of depression, OCD, and ADHD appeared to have a widespread negative impact on QoL, but poorer QoL was not associated with increased tic severity. Greater emotional and behavioral difficulties, including symptoms of OCD, were among the best predictors of poor QoL in young people with TS.

Lara 08-01-2011 06:41 AM
l-Histidine Decarboxylase and Tourette's Syndrome
 
My friend BB alerted me to this study...

so, FYI,

http://www.ncbi.nlm.nih.gov/pmc/arti...4/?tool=pubmed

N Engl J Med. Author manuscript; available in PMC 2010 November 20.
Published in final edited form as:
N Engl J Med. 2010 May 20; 362(20): 1901–1908.
Published online 2010 May 5. doi: 10.1056/NEJMoa0907006

l-Histidine Decarboxylase and Tourette's Syndrome
A. Gulhan Ercan-Sencicek, Ph.D., Althea A. Stillman, Ph.D., Ananda K. Ghosh, Ph.D., Kaya Bilguvar, M.D., Brian J. O'Roak, Ph.D., Christopher E. Mason, Ph.D., Thomas Abbott, Abha Gupta, M.D., Ph.D., Robert A. King, M.D., David L. Pauls, Ph.D., Jay A. Tischfield, Ph.D., Gary A. Heiman, Ph.D., Harvey S. Singer, M.D., Donald L. Gilbert, M.D., Pieter J. Hoekstra, M.D., Ph.D., Thomas M. Morgan, M.D., Erin Loring, M.S., Katsuhito Yasuno, Ph.D., Thomas Fernandez, M.D., Stephan Sanders, M.D., Angeliki Louvi, Ph.D., Judy H. Cho, M.D., Shrikant Mane, Ph.D., Christopher M. Colangelo, Ph.D., Thomas Biederer, Ph.D., Richard P. Lifton, M.D., Ph.D., Murat Gunel, M.D., and Matthew W. State, M.D., Ph.D.
Quote:
We have characterized a highly unusual two-generation pedigree in which Tourette's syndrome is segregated in an autosomal dominant fashion. Given that Tourette's syndrome has a population prevalence of 1% and a rate of recurrence of 10 to 15% among first-degree relatives of an affected person, it is extremely unlikely that all eight offspring of an affected parent would have Tourette's syndrome by chance, suggesting that this kindred indeed carries a mendelian form of the syndrome. The finding of a single segment of the genome that is shared among all affected members with a clearly deleterious mutation within this interval is also highly unlikely to occur by chance alone. Though the accepted standard for statistical significance on the basis of parametric linkage of a mendelian trait is a lod score of 3.0, these findings strongly point to a causal relationship between the identified mutation and Tourette's syndrome in this family.
Very interesting to me indeed...


Edited to add after more research:

I found this in OMIM http://omim.org/entry/142704#0001
after tracking an entry from http://omim.org/entry/137580

Quote:
Molecular Genetics
Mutation in the HDC Gene

By genomewide linkage analysis followed by candidate gene sequencing in a large 2-generation family with Gilles de la Tourette syndrome, Ercan-Sencicek et al. (2010) identified a heterozygous nonsense mutation in the HDC gene (W317X; 142704.0001) in all 9 affected individuals. In vitro studies indicated that the mutation exerted a dominant-negative effect on the protein, resulting in lack of enzyme activity. Ercan-Sencicek et al. (2010) noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety. Overall, the findings suggested a role for histaminergic neurotransmission in neurobehavioral actions, such as tics.
Quote:
.0001 GILLES DE LA TOURETTE SYNDROME
HDC, TRP317TER

In 9 affected members of a 2-generation family with Gilles de la Tourette syndrome (137580), Ercan-Sencicek et al. (2010) identified a heterozygous 951G-A transition in exon 9 of the HDC gene, resulting in a trp317-to-ter (W317X) substitution predicted to result in a truncated protein lacking key segments of the active domain. Studies of mRNA from patient cells suggested that the mutation escaped nonsense-mediated decay. The mutation was not found in 3,000 control chromosomes from northern and western Europe. In vitro studies in E. coli indicated that the mutant protein acted in a dominant-negative manner, resulting in lack of enzyme activity. All 9 affected individuals had Tourette syndrome, 4 also had obsessive-compulsive disorder (OCD; 164230), and 1 also had Asperger syndrome (see 608638).

Chemar 08-01-2011 08:20 PM
Interesting. Thanks Lara...I will need to read slowly and digest exactly what they are saying...lol my aging brain glazes over at science-speak these days :winky:

someone posted this one on Latitudes which elicited a lively convo!

http://www.scientificamerican.com/ar...ting-tourettes

My son is the exact opposite of what that suggests....as histamine *triggers* tics, and we think, OCD for him! Lots of anecdotal evidence from other posters there that their TS kids also seem to need less histamine not more! Many even find anti-histamines seem to help during waxing. Lots of TS kids also seem to have varied allergies

Lara 08-01-2011 09:26 PM
Remember it was just one family. [2 generations - father and his 8 children]

Plus... they're talking about a gene mutation in this particular family.
The other mutation that comes to mind was the SLITRK1 gene.
http://www.ninds.nih.gov/news_and_ev...ene_121505.htm

e.g.
Quote:
Variation in the SLITRK1 gene (609678) on 13q may also be associated with Tourette syndrome in some cases.
http://omim.org/entry/137580

I hear you.

Lara 09-21-2011 05:52 AM
CBT + Drugs Helps OCD in Children
 
http://neurotalk.psychcentral.com/thread157640.html
NeuroTalk - Health News Headlines
Cognitive Behavioral Therapy + Drugs Helps OCD in Children

Lara 11-06-2011 06:36 AM
Community Ment Health J. 2011 Nov 4.

PubMed Abstract

The Impact of Tourette Syndrome in Adults: Results from the Tourette Syndrome Impact Survey.

Conelea CA, Woods DW, Zinner SH, Budman CL, Murphy TK, Scahill LD, Compton SN, Walkup JT.

Lara 11-06-2011 06:42 AM
Eur Child Adolesc Psychiatry. 2011 Oct 27.

Prevalence and clinical correlates of tic disorders in a community sample of school-age children.

Tabori Kraft J, Dalsgaard S, Obel C, Thomsen PH, Henriksen TB, Scahill L.

PubMed Abstract

<snip>
Quote:
Children with hyperactivity and CTD were more impaired than subjects with CTD only. Children with CTD and hyperactivity show greater symptom severity across several domains of behavior and overall impairment. In the absence of hyperactivity, children with CTD are at increased risk for emotional difficulties, but not disruptive behavior problems.

Lara 12-02-2011 09:19 PM
Regarding Mecamylamine/Inversine etc.
 
Just posting this for the information of some of my TS friends who have, over many, many years now, been following the mecamylamine/inversine story.

http://www.healthiertalk.com/big-pha...d-history-4911

Big Pharma's new drug has a twisted history
By Dr. Allan Spreen on 11/09/2011

_______________

http://www.targacept.com/wt/page/pr_1320723633
Targacept Press Release
AstraZeneca and Targacept Announce First Top-line Phase 3 Results for TC-5214 as an Adjunct Treatment in Patients with Major Depressive Disorder

Wilmington, DE and Winston-Salem, NC

November 08, 2011

Quote:
AstraZeneca and Targacept, Inc. today announced top-line results from the first of four RENAISSANCE Phase 3 studies investigating the efficacy and tolerability of TC-5214 as an adjunct therapy to an antidepressant in patients with major depressive disorder (MDD) who do not respond adequately to initial antidepressant treatment. The study did not meet its primary endpoint of change on the Montgomery-Asberg Depression Rating Scale (MADRS) after eight weeks of treatment with TC-5214 as compared to placebo.
_______________

AstraZeneca, Targacept drug fails depression test
http://www.reuters.com/article/2011/...7A71KO20111108
Reuters
By Ben Hirschler
LONDON | Tue Nov 8, 2011 3:17pm EST

Quote:
TC-5214 is a tweaked version of mecamylamine, a drug introduced in the 1950s to treat high blood pressure.

Lara 01-10-2012 03:10 PM
Cautionary Note on Heat-Related Illness
 
Quote:
The following information is from the NYS Commission on Quality of Care and Advocacy for Persons with Disabilities. It was published in 2006, but is timeless advice for all of us, especially if we have family members or students on medications:
Cautionary Note on Heat-Related Illness
from Tourette Syndrome "Plus"

Lara 03-17-2012 05:58 PM
Toxoplasmosis
 
Quote:
Originally Posted by Lara (Post 483224)
<dead link removed>
A Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii
Elizabeth A. Gaskell, Judith E. Smith, John W. Pinney, Dave R. Westhead, and Glenn A. McConkey

from PubMed Central

PLoS ONE. 2009; 4(3): e4801.
Published online 2009 March 11. doi: 10.1371/journal.pone.0004801.
Just adding on some information here.
NOTE: the first link in the old post no longer worked so I removed it.

Eur Child Adolesc Psychiatry. 2001 Sep;10(3):200-4.
Obsessive-compulsive disorder and acquired toxoplasmosis in two children.
Brynska A, Tomaszewicz-Libudzic E, Wolanczyk T.
http://www.ncbi.nlm.nih.gov/pubmed/11596821
PMID: 11596821

Eur Arch Psychiatry Clin Neurosci. 2010 Jun;260(4):359-63.
Epub 2009 Nov 5.
Association between intracellular infectious agents and Tourette's syndrome.
Krause D, Matz J, Weidinger E, Wagner J, Wildenauer A, Obermeier M, Riedel M, Müller N.
http://www.ncbi.nlm.nih.gov/pubmed/19890596
PMID:19890596

Psychiatry Res. 2010 May 15;177(1-2):263-5.
Epub 2010 Jan 27.[B]
Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?
Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S.
http://www.ncbi.nlm.nih.gov/pubmed/20106536
PMID:20106536

Lara 04-04-2012 05:53 AM
Gilles De La Tourette syndrome: the current status.
 
Arch Dis Child Educ Pract Ed. 2012 Mar 22. [Epub ahead of print]
The Gilles De La Tourette syndrome: the current status.
Robertson MM.
http://www.ncbi.nlm.nih.gov/pubmed/22440810

Seems I have a lot to read. I might buy this full text actually. There are a lot of things stated by Prof Robertson in this abstract I'd like to understand more.

e.g.

Quote:
The most common comorbidities are attention deficit hyperactivity disorder, obsessive-compulsive behaviours, and disorder, and autistic spectrum disorders, while the most common coexisting psychopathologies are depression, anxiety and behavioural disorders such as oppositional defiant and conduct disorder.
Quote:
It is widely accepted that most cases of GTS are inherited, but the genetic mechanisms appear much more complex than previously understood, as evidenced by many recent studies; indeed, there have been suggestions of 'general neurodevelopmental genes' which affect the brain development after which the 'specific GTS gene(s)' may further affect the phenotype.
bold text added by me.

Lara 04-04-2012 06:05 AM
Genes Brain Behav. 2012 Mar 21. doi: 10.1111/j.1601-183X.2012.00778.x. [Epub ahead of print]
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette Syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/22435649

Lara 04-04-2012 06:08 AM
Eye tics as core feature of GTS
 
J Neurol. 2012 Mar 21. [Epub ahead of print]
Prevalence and phenomenology of eye tics in Gilles de la Tourette syndrome.
Martino D, Cavanna AE, Robertson MM, Orth M.
http://www.ncbi.nlm.nih.gov/pubmed/22434162

Quote:
Our data confirm that eye and eyelid/eyebrow movement tics are very common in GTS, and most patients have several types of eye tics over time. Eye tic phenomenology was similar in patients with or without co-morbidity.

Lara 04-04-2012 06:11 AM
Headaches and migraines
 
J Pediatr. 2012 Mar 15. [Epub ahead of print]
Headache in Children with Tourette Syndrome.
Ghosh D, Rajan PV, Das D, Datta P, Rothner AD, Erenberg G.
http://www.ncbi.nlm.nih.gov/pubmed/22424951

Quote:
The rate of migraine headache within the TS group was found to be 4 times greater than that of the general pediatric population, as reported in the literature. In addition, the rate of tension-type headache was found to be more than 5 times greater than that of the general pediatric population.

Lara 04-24-2012 08:40 AM
Stereotypic movement disorder: easily missed.
 
PubMed

Dev Med Child Neurol. 2010 Aug;52(8):733-8. Epub 2010 Feb 24.
Stereotypic movement disorder: easily missed.
Freeman RD, Soltanifar A, Baer S.
Department of Psychiatry and Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada

Quote:
SMD occurs in children without ASD or intellectual disability. The generally favorable clinical course is largely due to a gradual increase in private expression of the movements. Severity of the stereotypy is associated with sensory differences and psychopathology. Differentiation of SMD from tics and ASD is important to avoid misdiagnosis and unnecessary treatment.

Lara 04-08-2013 02:33 PM
Immune System and Schizophrenia
 
Not regarding TS however these are very interesting findings regarding Schizophrenia and the Immune System. Just posting here because I think this could be relevant to a number of conditions. Just my thoughts.

UTI Far More Likely After Schizophrenia Relapse
By Traci Pedersen Associate News Editor
from PsychCentral

http://psychcentral.com/news/2013/04...pse/53514.html

Lara 05-02-2013 03:55 PM
Antibacteral Soap
 
Just FYI

Decades-old question: Is antibacterial soap safe?

Regarding Triclosan in Antibacterial soap.
From Yahoo


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