Air swallowing as a tic
PubMed
J Psychosom Res. 2008 Nov;65(5):497-500. Epub 2008 Oct 1. Air swallowing as a tic. Weil RS, Cavanna AE, Willoughby JM, Robertson MM. Institute of Neurology, Queen Square, London, UK. Quote:
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NEJM Research Antipsychotics & Cardiac Risk
http://content.nejm.org/cgi/content/short/360/3/225
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Dopamine and Toxoplasmosis
From Bot's news -
Parasite may trigger schizophrenia Quote:
Elizabeth A. Gaskell, Judith E. Smith, John W. Pinney, Dave R. Westhead, and Glenn A. McConkey from PubMed Central PLoS ONE. 2009; 4(3): e4801. Published online 2009 March 11. doi: 10.1371/journal.pone.0004801. |
TS and comorbid PDDs
http://jcn.sagepub.com/cgi/content/abstract/24/2/170
Journal of Child Neurology, Vol. 24, No. 2, 170-175 (2009) DOI: 10.1177/0883073808322666 Tourette Syndrome and Comorbid Pervasive Developmental Disorders Larry Burd, Qing Li, Jacob Kerbeshian, Marilyn G. Klug, Roger D. Freeman Quote:
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PubMed Article
J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):13-23.Links The behavioral spectrum of Gilles de la Tourette syndrome. Cavanna AE, Servo S, Monaco F, Robertson MM. Quote:
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PubMed Article
Mov Disord. 2009 Apr 7 Immunopathogenic mechanisms in tourette syndrome: A critical review. Martino D, Dale RC, Gilbert DL, Giovannoni G, Leckman JF. Quote:
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PubMed Article
J Neurol. 2009 Mar 14. A preliminary study of the frequency of anti-basal ganglia antibodies and streptococcal infection in attention deficit/hyperactivity disorder. Sanchez-Carpintero R, Albesa SA, Crespo N, Villoslada P, Narbona J. Quote:
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Immunopathogenic mechanisms in tourette syndrome
http://neurotalk.psychcentral.com/post499139-46.html
I already posted this one but I'll leave it here and quote the material regarding T cells. PubMed Mov Disord. 2009 Apr 7. Immunopathogenic mechanisms in tourette syndrome: A critical review. Martino D, Dale RC, Gilbert DL, Giovannoni G, Leckman JF. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy. <snipped abstract> Quote:
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Immunophenotyping in Tourette syndrome--a pilot study.
PubMed
Eur J Neurol. 2008 Jul;15(7):749-53. Epub 2008 May 15. Immunophenotyping in Tourette syndrome--a pilot study. Möller JC, Tackenberg B, Heinzel-Gutenbrunner M, Burmester R, Oertel WH, Bandmann O, Müller-Vahl KR. Department of Neurology, Philipps-University, Marburg, Germany |
Decreased numbers of regulatory T cells
PubMed
Biol Psychiatry. 2007 Feb 1;61(3):273-8. Epub 2006 Sep 25. Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study. Kawikova I, Leckman JF, Kronig H, Katsovich L, Bessen DE, Ghebremichael M, Bothwell AL. Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut <snipped article> Quote:
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Genomic profiles for human peripheral blood T cells, B cells etc...
PubMed
Genomics. 2006 Jun;87(6):693-703. Epub 2006 Mar 20 Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Du X, Tang Y, Xu H, Lit L, Walker W, Ashwood P, Gregg JP, Sharp FR. MIND Institute, University of California at Davis |
OCD - Immunological alterations
old abstract - 1999
PubMed Biol Psychiatry. 1999 Sep 15;46(6):810-4. Immunological alterations in adult obsessive-compulsive disorder. Marazziti D, Presta S, Pfanner C, Gemignani A, Rossi A, Sbrana S, Rocchi V, Ambrogi F, Cassano GB. Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy. Quote:
PubMed Psychiatry Res. 2001 Nov 30;104(3):221-5. The use of antibody D8/17 to identify B cells in adults with obsessive-compulsive disorder. Eisen JL, Leonard HL, Swedo SE, Price LH, Zabriskie JB, Chiang SY, Karitani M, Rasmussen SA. Department of Psychiatry and Human Behavior, Butler Hospital, Brown University School of Medicine, Quote:
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Full Text of 2006 TS genome scan
PubMed Central Full Text Article
Am J Hum Genet. 2007 February; 80(2): 265–272. Published online 2006 December 12. PMCID: PMC1785345 Genome Scan for Tourette Disorder in Affected-Sibling-Pair and Multigenerational Families The Tourette Syndrome Association International Consortium for Genetics |
superantigen hypothesis
excerpt from Book...
Tourette's syndrome--tics, obsessions, compulsions By James F. Leckman, Donald J. Cohen (1998) from Google Books |
Functional Disturbances Within Frontostriatal Circuits
PubMed
Am J Psychiatry. 2009 May 15. Functional Disturbances Within Frontostriatal Circuits Across Multiple Childhood Psychopathologies. Marsh R, Maia TV, Peterson BS. <snipped abstract> Quote:
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Prefrontal and anterior cingulate cortex abnormalities (VBM) (MTI)
Note: small sized study.
PubMed BMC Neurosci. 2009 May 12;10(1):47. Prefrontal and anterior cingulate cortex abnormalities in Tourette Syndrome: evidence from voxel-based morphometry and magnetization transfer imaging. Muller-Vahl KR, Kaufmann J, Grosskreutz J, Dengler R, Emrich HM, Peschel T. |
stimulus evaluation, response inhibition and motor processing
PubMed
Psychiatry Res. 2009 May 30;167(3):202-20. Electrophysiological manifestations of stimulus evaluation, response inhibition and motor processing in Tourette syndrome patients. Thibault G, O'Connor KP, Stip E, Lavoie ME. Centre de Recherche Fernand-Seguin and Hôpital Louis-H. Lafontaine, Montréal, Québec, Canada; Département de Psychologie, Université de Montréal, Montréal, Québec, Canada. |
Long needle acupuncture
PubMed
Zhongguo Zhen Jiu. 2009 Feb;29(2):115-8.Links Clinical study on scalp acupuncture with long needle-retained duration for treatment of Tourette syndrome [Article in Chinese] Zhu BC, Shi-fen X, Shan YH. Department of Acupuncture, Shanghai Hospital of TCM, Shanghai |
The behavioral spectrum of Gilles de la Tourette syndrome.
PubMed
J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):13-23. The behavioral spectrum of Gilles de la Tourette syndrome. Cavanna AE, Servo S, Monaco F, Robertson MM. Sobell Department of Movement Disorders, Institute of Neurology, London, UK. <snipped abstract> Quote:
Full Text at a price |
Stuttering (from my bookmarks)
http://www.ncbi.nlm.nih.gov/pubmed/10907717
J Commun Disord. 2000 May-Jun;33(3):227-39; Dysfluency and phonic tics in Tourette syndrome: a case report. Van Borsel J, Vanryckeghem M. http://www.mnsu.edu/comdis/isad2/papers/molt2.html The Basal Ganglia's Possible Role in Stuttering: An Examination of Similarities between Stuttering, Tourette Syndrome, Dystonia, and other Neurological-Based Disorders of Movement by Larry Molt http://www.mnsu.edu/comdis/isad6/papers/donaher6.html Disfluency Associated with Tourette's Syndrome: Two Case Studies by John Tetnowski and Joseph Donaher http://www.stutteringhelp.org/Default.aspx?tabid=440 Stuttering and Tourette's Syndrome This material was compiled by Luc De Nil, Ph.D., Chair of the Graduate Department of Speech-Language Pathology, University of Toronto, and by Paul Sandor, M.D., Director of the Tourette’s Syndrome Clinic, University Health Network. http://www.cmaj.ca/cgi/content/full/162/13/1849 Stuttering: an update for physicians Daniel Costa and Robert Kroll http://www.ncbi.nlm.nih.gov/pubmed/15856831 Rev Laryngol Otol Rhinol (Bord). 2004;125(5):297-301. Links Stuttering and Tourette's syndrome: a short tutorial and account of a four years experience in a stuttering clinic constriction of the vocal tract [Article in French] Monfrais-Pfauwadel MC. Hopital Europeen Georges Pompidou, AP-HP, Paris, France Quote:
Differential Diagnosis of Stuttering and Self-referral by Marie-Claude Monfrais-Pfauwadel from France http://www.unboundmedicine.com/medli...t=10&prev=true |
PubMed Abstract
Mol Psychiatry. 2009 Jun 23. Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Elia J, Gai X, Xie HM, Perin JC, Geiger E, Glessner JT, D'arcy M, Deberardinis R, Frackelton E, Kim C, Lantieri F, Muganga BM, Wang L, Takeda T, Rappaport EF, Grant SF, Berrettini W, Devoto M, Shaikh TH, Hakonarson H, White PS. Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Quote:
from Psych Central News Gene Variations Linked to ADHD By Psych Central News Editor Reviewed by John M. Grohol, Psy.D. on June 25, 2009 |
Which Neurodevelopmental Disorders Get Researched and Why?
Bishop DV. Developmental Neuropsychology, University of Oxford, Oxford, United Kingdom |
Tics after TBI
PubMed Abstract
Brain Inj. 2011;25(6):629-33. Tics after traumatic brain injury. Ranjan N, Nair KP, Romanoski C, Singh R, Venketswara G. Source Sheffield Teaching Hospitals NHS Trust , Sheffield , UK. |
PubMed Abstract
Mov Disord. 2011 Mar;26(4):735-8. doi: 10.1002/mds.23434. Epub 2010 Nov 10. Clinical correlates of quality of life in Tourette syndrome. Eddy CM, Cavanna AE, Gulisano M, Agodi A, Barchitta M, Calì P, Robertson MM, Rizzo R. Source Department of Neuropsychiatry, The Barberry National Centre for Mental Health, Birmingham, United Kingdom. Abstract <snip> Quote:
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l-Histidine Decarboxylase and Tourette's Syndrome
My friend BB alerted me to this study...
so, FYI, http://www.ncbi.nlm.nih.gov/pmc/arti...4/?tool=pubmed N Engl J Med. Author manuscript; available in PMC 2010 November 20. Published in final edited form as: N Engl J Med. 2010 May 20; 362(20): 1901–1908. Published online 2010 May 5. doi: 10.1056/NEJMoa0907006 l-Histidine Decarboxylase and Tourette's Syndrome A. Gulhan Ercan-Sencicek, Ph.D., Althea A. Stillman, Ph.D., Ananda K. Ghosh, Ph.D., Kaya Bilguvar, M.D., Brian J. O'Roak, Ph.D., Christopher E. Mason, Ph.D., Thomas Abbott, Abha Gupta, M.D., Ph.D., Robert A. King, M.D., David L. Pauls, Ph.D., Jay A. Tischfield, Ph.D., Gary A. Heiman, Ph.D., Harvey S. Singer, M.D., Donald L. Gilbert, M.D., Pieter J. Hoekstra, M.D., Ph.D., Thomas M. Morgan, M.D., Erin Loring, M.S., Katsuhito Yasuno, Ph.D., Thomas Fernandez, M.D., Stephan Sanders, M.D., Angeliki Louvi, Ph.D., Judy H. Cho, M.D., Shrikant Mane, Ph.D., Christopher M. Colangelo, Ph.D., Thomas Biederer, Ph.D., Richard P. Lifton, M.D., Ph.D., Murat Gunel, M.D., and Matthew W. State, M.D., Ph.D. Quote:
Edited to add after more research: I found this in OMIM http://omim.org/entry/142704#0001 after tracking an entry from http://omim.org/entry/137580 Quote:
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Interesting. Thanks Lara...I will need to read slowly and digest exactly what they are saying...lol my aging brain glazes over at science-speak these days :winky:
someone posted this one on Latitudes which elicited a lively convo! http://www.scientificamerican.com/ar...ting-tourettes My son is the exact opposite of what that suggests....as histamine *triggers* tics, and we think, OCD for him! Lots of anecdotal evidence from other posters there that their TS kids also seem to need less histamine not more! Many even find anti-histamines seem to help during waxing. Lots of TS kids also seem to have varied allergies |
Remember it was just one family. [2 generations - father and his 8 children]
Plus... they're talking about a gene mutation in this particular family. The other mutation that comes to mind was the SLITRK1 gene. http://www.ninds.nih.gov/news_and_ev...ene_121505.htm e.g. Quote:
I hear you. |
CBT + Drugs Helps OCD in Children
http://neurotalk.psychcentral.com/thread157640.html
NeuroTalk - Health News Headlines Cognitive Behavioral Therapy + Drugs Helps OCD in Children |
Community Ment Health J. 2011 Nov 4.
PubMed Abstract The Impact of Tourette Syndrome in Adults: Results from the Tourette Syndrome Impact Survey. Conelea CA, Woods DW, Zinner SH, Budman CL, Murphy TK, Scahill LD, Compton SN, Walkup JT. |
Eur Child Adolesc Psychiatry. 2011 Oct 27.
Prevalence and clinical correlates of tic disorders in a community sample of school-age children. Tabori Kraft J, Dalsgaard S, Obel C, Thomsen PH, Henriksen TB, Scahill L. PubMed Abstract <snip> Quote:
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Regarding Mecamylamine/Inversine etc.
Just posting this for the information of some of my TS friends who have, over many, many years now, been following the mecamylamine/inversine story.
http://www.healthiertalk.com/big-pha...d-history-4911 Big Pharma's new drug has a twisted history By Dr. Allan Spreen on 11/09/2011 _______________ http://www.targacept.com/wt/page/pr_1320723633 Targacept Press Release AstraZeneca and Targacept Announce First Top-line Phase 3 Results for TC-5214 as an Adjunct Treatment in Patients with Major Depressive Disorder Wilmington, DE and Winston-Salem, NC November 08, 2011 Quote:
AstraZeneca, Targacept drug fails depression test http://www.reuters.com/article/2011/...7A71KO20111108 Reuters By Ben Hirschler LONDON | Tue Nov 8, 2011 3:17pm EST Quote:
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Cautionary Note on Heat-Related Illness
Quote:
from Tourette Syndrome "Plus" |
Toxoplasmosis
Quote:
NOTE: the first link in the old post no longer worked so I removed it. Eur Child Adolesc Psychiatry. 2001 Sep;10(3):200-4. Obsessive-compulsive disorder and acquired toxoplasmosis in two children. Brynska A, Tomaszewicz-Libudzic E, Wolanczyk T. http://www.ncbi.nlm.nih.gov/pubmed/11596821 PMID: 11596821 Eur Arch Psychiatry Clin Neurosci. 2010 Jun;260(4):359-63. Epub 2009 Nov 5. Association between intracellular infectious agents and Tourette's syndrome. Krause D, Matz J, Weidinger E, Wagner J, Wildenauer A, Obermeier M, Riedel M, Müller N. http://www.ncbi.nlm.nih.gov/pubmed/19890596 PMID:19890596 Psychiatry Res. 2010 May 15;177(1-2):263-5. Epub 2010 Jan 27.[B] Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S. http://www.ncbi.nlm.nih.gov/pubmed/20106536 PMID:20106536 |
Gilles De La Tourette syndrome: the current status.
Arch Dis Child Educ Pract Ed. 2012 Mar 22. [Epub ahead of print]
The Gilles De La Tourette syndrome: the current status. Robertson MM. http://www.ncbi.nlm.nih.gov/pubmed/22440810 Seems I have a lot to read. I might buy this full text actually. There are a lot of things stated by Prof Robertson in this abstract I'd like to understand more. e.g. Quote:
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Genes Brain Behav. 2012 Mar 21. doi: 10.1111/j.1601-183X.2012.00778.x. [Epub ahead of print]
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette Syndrome. http://www.ncbi.nlm.nih.gov/pubmed/22435649 |
Eye tics as core feature of GTS
J Neurol. 2012 Mar 21. [Epub ahead of print]
Prevalence and phenomenology of eye tics in Gilles de la Tourette syndrome. Martino D, Cavanna AE, Robertson MM, Orth M. http://www.ncbi.nlm.nih.gov/pubmed/22434162 Quote:
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Headaches and migraines
J Pediatr. 2012 Mar 15. [Epub ahead of print]
Headache in Children with Tourette Syndrome. Ghosh D, Rajan PV, Das D, Datta P, Rothner AD, Erenberg G. http://www.ncbi.nlm.nih.gov/pubmed/22424951 Quote:
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Stereotypic movement disorder: easily missed.
PubMed
Dev Med Child Neurol. 2010 Aug;52(8):733-8. Epub 2010 Feb 24. Stereotypic movement disorder: easily missed. Freeman RD, Soltanifar A, Baer S. Department of Psychiatry and Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada Quote:
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Immune System and Schizophrenia
Not regarding TS however these are very interesting findings regarding Schizophrenia and the Immune System. Just posting here because I think this could be relevant to a number of conditions. Just my thoughts.
UTI Far More Likely After Schizophrenia Relapse By Traci Pedersen Associate News Editor from PsychCentral http://psychcentral.com/news/2013/04...pse/53514.html |
Antibacteral Soap
Just FYI
Decades-old question: Is antibacterial soap safe? Regarding Triclosan in Antibacterial soap. From Yahoo |
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