Sensory Tricks - geste antagoniste
 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607913/
Tic Modulation Using Sensory Tricks
Rebecca Wolf Gilbert
Tremor Other Hyperkinet Mov (N Y). 2013; 3: tre-03-115-3129-1.
Published online 2013 March 26.
PMCID: PMC3607913

National Library of Medicine (NLM)

How does psychoeducation help?
 

http://www.ncbi.nlm.nih.gov/pubmed/23461278
How does psychoeducation help? A review of the effects of providing information about Tourette syndrome and attention-deficit/hyperactivity disorder.
Nussey C, Pistrang N, Murphy T.
Brent Older Adult Service, London, UK.

Child Care Health Dev. 2013 Mar 5. doi: 10.1111/cch.12039.
[Epub ahead of print]

OMIM page GTS
 

http://omim.org/entry/137580
Online Mendelian Inheritance in Man
GILLES DE LA TOURETTE SYNDROME; GTS

Azithromycin
 

http://www.nejm.org/doi/full/10.1056/NEJMp1302726
Cardiovascular Risks with Azithromycin and Other Antibacterial Drugs

Andrew D. Mosholder, M.D., M.P.H., Justin Mathew, Pharm.D., John J. Alexander, M.D., M.P.H., Harry Smith, Ph.D., and Sumathi Nambiar, M.D., M.P.H.

N Engl J Med 2013; 368:1665-1668
May 2, 2013
DOI: 10.1056/NEJMp1302726

___________________________

http://clinicaltrials.gov/show/NCT01617083
Clinical Trials
Antibiotic Treatment Trial for the PANDAS/PANS Phenotype (AZT)
ClinicalTrials.gov processed this record on April 30, 2013

Caucus for TS
 

US Congress Creates Caucus for Tourette Syndrome

Child/Adolescent Psychiatry
Congress creates caucus for Tourette syndrome

By: ALICIA AULT, Clinical Psychiatry News Digital Network
5/17/13

Putting some older articles together re: ferritin, iron
 

http://www.chemistry.wustl.edu/~edud.../Ferritin.html
Iron Use and Storage in the Body:
Ferritin and Molecular Representations
Iron in Biology: Study of the Iron Content in Ferritin, The Iron-Storage Protein

________________________


JAMA Pediatrics
Iron Deficiency in Children With Attention-Deficit/Hyperactivity Disorder
Eric Konofal, MD, PhD; Michel Lecendreux, MD; Isabelle Arnulf, MD, PhD; Marie-Christine Mouren, MD
Arch Pediatr Adolesc Med. 2004;158:1113-1115

______________________

PubMed

J Neural Transm. 2012 May;119(5):621-6. doi: 10.1007/s00702-011-0739-x. Epub 2011 Dec 3.
Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette's syndrome.
Landau YE, Steinberg T, Richmand B, Leckman JF, Apter A.

_____________________

Hypothesis

PubMed
Med Hypotheses. 2008;70(6):1128-32. doi: 10.1016/j.mehy.2007.10.013. Epub 2007 Dec 27.
Attention-deficit/hyperactivity disorder, Tourette's syndrome, and restless legs syndrome: the iron hypothesis.
Cortese S, Lecendreux M, Bernardina BD, Mouren MC, Sbarbati A, Konofal E.

_____________________

PubMed
Psychiatry Res. 1994 Dec;55(4):205-21.
Abnormal magnetic resonance imaging T2 relaxation time asymmetries in Tourette's syndrome.
Peterson BS, Gore JC, Riddle MA, Cohen DJ, Leckman JF.

____________________


PubMed
Front Aging Neurosci. 2013 Jul 18;5:34. doi: 10.3389/fnagi.2013.00034. eCollection 2013.
A delicate balance: Iron metabolism and diseases of the brain.
Hare D, Ayton S, Bush A, Lei P

JAMA
Original Article | September 2010
Enlargement of Thalamic Nuclei in Tourette Syndrome

Arch Gen Psychiatry. 2010;67(9):955-964. doi:10.1001/archgenpsychiatry.2010.102

_____________________

Interesting older article ... esp. section titled "WHEN NEURAL COMPENSATION AND PROTECTION FAIL" regarding symptom severity and gender differences.

JAMA
Original Article | November 2007
Morphologic Features of the Amygdala and Hippocampus in Children and Adults With Tourette Syndrome

Arch Gen Psychiatry. 2007;64(11):1281-1291. doi:10.1001/archpsyc.64.11.1281.

_____________________

PubMed
Int Rev Neurobiol. 2013;112:73-93. doi: 10.1016/B978-0-12-411546-0.00003-2.
Functional imaging of dopaminergic neurotransmission in tourette syndrome.
Segura B, Strafella AP.

_____________________

http://www.ncbi.nlm.nih.gov/pubmed/20225192
Ann Neurol. 2010 Feb;67(2):170-81. doi: 10.1002/ana.21809.
Extrastriatal dopaminergic dysfunction in tourette syndrome.
Steeves TD, Ko JH, Kideckel DM, Rusjan P, Houle S, Sandor P, Lang AE, Strafella AP

Excited to read some good information on TS.. thank you!

HDC (Histidine Decarboxylase) gene
 

Neuron

Volume 81, Issue 1, 8 January 2014, Pages 77–90

Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
http://www.sciencedirect.com/science...96627313010040

------

TSA News
New Findings Shed Light on the Genetics of Tourette Syndrome
http://tsa-usa.org/news/0114ToureteS...wFindings.html

------

Yale News
http://news.yale.edu/2014/01/08/yale...rette-syndrome

------

NINDS news article
http://www.ninds.nih.gov/news_and_ev...20Syndrome.htm

Adding on an old related post as I couldn't edit it to add on this new info...

http://neurotalk.psychcentral.com/post791641-65.html
l-Histidine Decarboxylase and Tourette's Syndrome

ADHD - Communication
 

Interesting article from PsychCentral regarding ADHD and communication difficulties.

ADHD Associated with Communication Problems

http://jslhr.pubs.asha.org/article.a...icleid=1795793
Referential Communication in Children With ADHD: Challenges in the Role of a Listener
Elizabeth S. Nilsen; Leilani Mangal; Kristi MacDonald

http://jad.sagepub.com/content/17/7/589.abstract
Communicative Perspective-Taking Performance of Adults With ADHD Symptoms

ADHD - Aspergers Communication Impairments
 

Exploring Language Profiles for Children With ADHD and Children With Asperger Syndrome
http://jad.sagepub.com/content/16/1/34.full.pdf+html

Hi lara
 

These links are very interesting .I have just been reading your links on iron defiency and rang bells for me.My son was always low on iron and even had a alergic reaction to low iron where his body swelled and hives that was very big and left bruises.Im wondering if anyone else had low iron?

My daughter has constant problems maintaining normal Ferritin levels but she also has had extremely low B12 and has a few medical conditions that may play into all of this. She always only had very mild tics, more anxiety,ocd issues. I don't remember what my son's levels were. It wasn't something they were looking at way back then and any blood tests that were done routinely for him were Strep. related (GABHS). Both of them have immune system related issues. There also appears to be a link to Restless Leg Syndrome (yet another condition relating to dopamine dysfunction) which I have, although that's been very stable for me for a long time now thankfully.

EDITED to add: Katy, I'm just curious, but does your son have a gluten intolerance?

Hi lara:) not that i know he has bowel leakage problems and on med for that. I find the links very interesting lara and thankyou for putting your time in to deliver themxx

Anger control problems strongly correlated with comorbidity
 

Anger control problems are strongly correlated with comorbidity

J Am Acad Child Adolesc Psychiatry. 2003 Jan;42(1):98-105.
Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment.
Sukhodolsky DG1, Scahill L, Zhang H, Peterson BS, King RA, Lombroso PJ, Katsovich L, Findley D, Leckman JF.
PubMed Abstract

J Am Acad Child Adolesc Psychiatry. 2000 Oct;39(10):1270-6.
Explosive outbursts in children with Tourette's disorder.
Budman CL1, Bruun RD, Park KS, Lesser M, Olson M.
PubMed Abstract

Dev Med Child Neurol. 2000 Jul;42(7):436-47.
An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries.
Freeman RD1, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P.
PubMed Abstract

Can J Psychiatry. 1999 Dec;44(10):1036-42.
Aggressive behaviour in children with Tourette syndrome and comorbid attention-deficit hyperactivity disorder and obsessive-compulsive disorder.
Stephens RJ1, Sandor P.
PubMed Abstract

http://www.tsa-usa.org/Z_TSA_video/intro.html

VIDEO - TSA-USA

Tourette Syndrome: A Psychiatrist Talks to Parents about Anger -
John T. Walkup, MD

Books - Behavioural challenges
 

Greene, R. W. (2010).
The explosive child: A new approach for understanding and parenting easily frustrated, "chronically inflexible" children (Revised 4th edition).
New York: HarperCollins.

Greene, R.W. (2009).
Lost at school: Why our kids with behavioral challenges are falling through the cracks and how we can help them (Revised 2nd edition).
New York: Scribner.

Clinical Trial AZD5213
 

Wow, they seem to have jumped all over this very fast.

Just posting this Clinical Trial info. below as a follow up to the articles in a previous post which was...
HDC (Histidine Decarboxylase) gene

_____________

http://www.tsa-usa.org/aResearch/Saf...l_AZD5213.html

• Non-TSA Funded Study

Safety, Tolerability, Pharmacokinetic, and Efficacy of AZD5213 in Adolescents With Tourette's Disorder
Summit, NJ; Orange, CA; New York, NY; St. Petersburg, FL

http://clinicaltrials.gov/ct2/show/NCT01904773
Safety, Tolerability, Pharmacokinetic, and Efficacy Study of AZD5213 in Adolescents With Tourette's Disorder
This study is currently recruiting participants.

[Added note:
Sponsor:AstraZeneca]

_____________

http://www.prweb.com/releases/2014/03/prweb11637784.htm
March 05, 2014
- gives an explanation about how their drug targets histamine H3 receptor.
- dopamine regulation

_____________

I've just been doing some detective work and what do you know...

There's that T word again... Targacept

AstraZeneca quietly sweeps out some notable mid-stage drug programs
February 6, 2014 | By John Carroll
http://www.fiercebiotech.com/story/a...ams/2014-02-06

_____________

Targacept

http://neurotalk.psychcentral.com/post829509-71.html
Regarding Mecamylamine/Inversine etc.
TC-5214

Altered monocyte activation markers TS
 

from 2012 -

http://www.biomedcentral.com/1471-244X/12/29

Altered monocyte activation markers in Tourette’s syndrome: a case–control study

Judith Matz, Daniela L Krause, Sandra Dehning, Michael Riedel, Rudolf Gruber, Markus J Schwarz and Norbert Müller



BMC Psychiatry 2012, 12:29
doi:10.1186/1471-244X-12-29

This is an Open Access article distributed under the terms of the Creative Commons Attribution License

Iron Deficiency Anemia
 

Interesting

http://www.biomedcentral.com/1471-244X/13/161

Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study

Mu-Hong Chen, Tung-Ping Su, Ying-Sheue Chen, Ju-Wei Hsu, Kai-Lin Huang, Wen-Han Chang, Tzeng-Ji Chen and Ya-Mei Bai

OT - Valacyclovir/Valtrex
 

Off Topic FYI

This first one is a single case study but it is a very interesting article despite the limitations and the financial disclosures of the doctor.

Is Valacyclovir a Mood Stabilizer? Autism 3:118. doi:
Henderson TA (2013)
http://www.omicsgroup.org/journals/i....php?aid=19860

[open-access article distributed under the terms of the Creative Commons Attribution License]

Adv Mind Body Med. 2014 Winter;28(1):4-14.
Valacyclovir treatment of chronic fatigue in adolescents.
Henderson TA.
http://www.ncbi.nlm.nih.gov/pubmed/24445302

TBI - Adult onset Tics
 

http://www.ncbi.nlm.nih.gov/pubmed/21534741
Brain Inj. 2011;25(6):629-33. doi: 10.3109/02699052.2011.572944.
Tics after traumatic brain injury.
Ranjan N1, Nair KP, Romanoski C, Singh R, Venketswara G.
Abstract

http://informahealthcare.com/doi/abs...52.2011.572944
Full Text - Brain Injury, June 2011; 25(6): 629–633
Access has changed since this was first posted.
Full Text now pay per view.

_____________________

http://www.ncbi.nlm.nih.gov/pubmed/15867978
Rev Bras Psiquiatr. 2005 Mar;27(1):11-7. Epub 2005 Apr 18.
Secondary tics and tourettism.
Mejia NI1, Jankovic J.
Abstract

http://www.scielo.br/pdf/rbp/v27n1/23707.pdf
Revista Brasileira de Psiquiatria 2005;27:11–17
Secondary Tics and Tourettism
Nicte I Mejia, Joseph Jankovic
[head trauma]
Full Text

Motor excitability during movement preparation - TS
 

from Nov, 2013
Note small number of participants -
9 male. one female.
several with co-morbids.
some medicated. some not.
Nonetheless, it's an interesting study. :)

http://onlinelibrary.wiley.com/doi/1...jnp.12033/full
Motor excitability during movement preparation in Tourette syndrome
Amelia Draper, Lucinda Jude, Georgina M. Jackson and Stephen R. Jackson,
Article first published online: 28 NOV 2013
DOI: 10.1111/jnp.12033

http://psychcentral.com/news/2013/12...ome/63922.html
Scientists Tie Brain Mechanism To Tics in Tourette Syndrome

http://www.nottingham.ac.uk/news/pre...rome-tics.aspx
Researchers uncover mechanism controlling Tourette Syndrome tics
Click on - Click here for full story

TS, OCD - Differences in genetic architecture
 

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive
Disorder Reveals Differences in Genetic Architecture

from PLOS Genetics

Published: October 24, 2013
DOI: 10.1371/journal.pgen.1003864

Note: "This is an open-access article, free of all copyright"

Impaired activation of innate immune response -
 

http://informahealthcare.com/doi/abs...75.2014.907503

World J Biol Psychiatry. 2014 Jun 9:1-6. [Epub ahead of print]
Impaired activation of the innate immune response to bacterial challenge in Tourette syndrome.
Weidinger E, Krause D, Wildenauer A, Meyer S, Gruber R, Schwarz MJ, Müller N.

[I haven't read full text yet, only this abstract. $46US for 23hrs seemed a little steep]

Febrile convulsions increase risk of TS
 

http://www.seizure-journal.com/artic...138-1/abstract
Seizure - European Journal of Epilepsy
Febrile convulsions increase risk of Tourette syndrome
Yi-Fang Tu, Cheng-Li Lin, Chih-Hao Lin, Chao-Chin Huang, Fung-Chang Sung, Chia-Huang Kaoemail
Published Online: May 19, 2014

_______________

:confused:

Edited to add my comment -

I would wonder what type of illness or infection actually caused the febrile convulsions in the first place

Well I know strep infections can cause febrile convulsions as can other childhood viruses and bacterial infections....I wonder if what these researchers were finding was more related to PANS rather than TS?

Well that was sort of what I was thinking.
I'd love to read the full text when it is free, otherwise it is a bit of a puzzle.
My first thought was about the actual conditions that preceded the seizures in all of those patients to cause the fever in the first place.

Interesting too, is that there was another article on that same page suggesting that low iron and low serum ferritin may be risk factors for febrile seizures in children.

Association between iron status and febrile seizures in children
Soheila Zareifar, Hamid Reza Hosseinzadeh, Nader Cohan

http://neurotalk.psychcentral.com/post1041370-86.html
older articles re: ferritin, iron

anyway...

J Am Acad Child Adolesc Psychiatry. 2015 Jun
Epub 2015 Mar 17.

PubMed Abstract

Maternal history of autoimmune disease and later development of tourette syndrome in offspring.

Dalsgaard S, Waltoft BL, Leckman JF, Mortensen PB.

PLoS One. 2015 Mar 20;
10(3):e0120499. doi: 10.1371/journal.pone.0120499.
eCollection 2015.

PubMed Abstract

Neuronal antibody biomarkers for Sydenham's chorea identify a new group of children with chronic recurrent episodic acute exacerbations of tic and obsessive compulsive symptoms following a streptococcal infection.

Harvey S. Singer , Adda Mascaro-Blanco, Kathy Alvarez, Christina Morris-Berry, Ivana Kawikova, Hilla Ben-Pazi,Carol B. Thompson, Syed F. Ali, Edward L. Kaplan, Madeleine W. Cunningham

An Overview of Tourette Syndrome by Sheila Rogers DeMare
http://latitudes.org/conditions/what...ette-syndrome/