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-   Tourette Syndrome (https://www.neurotalk.org/tourette-syndrome/)
-   -   Articles, Abstracts and News Reports on TS (https://www.neurotalk.org/tourette-syndrome/16243-articles-abstracts-news-reports-ts.html)

Lara 01-12-2009 08:50 AM
Air swallowing as a tic
 
PubMed

J Psychosom Res. 2008 Nov;65(5):497-500. Epub 2008 Oct 1.
Air swallowing as a tic.
Weil RS, Cavanna AE, Willoughby JM, Robertson MM.

Institute of Neurology, Queen Square, London, UK.

Quote:
The authors present a patient with Gilles de la Tourette syndrome who developed abdominal distension and bloating due to air swallowing. We suggest that this air swallowing may have been due to a tic.

Chemar 01-15-2009 09:39 AM
NEJM Research Antipsychotics & Cardiac Risk
 
http://content.nejm.org/cgi/content/short/360/3/225

Quote:
Conclusions: Current users of typical and of atypical antipsychotic drugs had a similar, dose-related increased risk of sudden cardiac death.

Lara 03-18-2009 05:29 PM
Dopamine and Toxoplasmosis
 
From Bot's news -

Parasite may trigger schizophrenia

Quote:
The team found the parasite's genetic make-up included an enzyme that aids in the production of dopamine. "At this point the research is too premature to suggest changes in treatment" of schizophrenia, McConkey continued. Nonetheless, "Toxoplasmosis screening would be warranted in psychological analysis."
He and his colleagues now plan to explore the possible role of toxoplasma in other neurological diseases associated with dopamine, including autism, Parkinson's disease, and Tourette's syndrome.
A Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii
Elizabeth A. Gaskell, Judith E. Smith, John W. Pinney, Dave R. Westhead, and Glenn A. McConkey

from PubMed Central

PLoS ONE. 2009; 4(3): e4801.
Published online 2009 March 11. doi: 10.1371/journal.pone.0004801.

Lara 03-20-2009 09:35 AM
TS and comorbid PDDs
 
http://jcn.sagepub.com/cgi/content/abstract/24/2/170
Journal of Child Neurology, Vol. 24, No. 2, 170-175 (2009)
DOI: 10.1177/0883073808322666

Tourette Syndrome and Comorbid Pervasive Developmental Disorders
Larry Burd, Qing Li, Jacob Kerbeshian, Marilyn G. Klug, Roger D. Freeman

Quote:
We found 334 (4.6%; 1 of every 22 participants) with Tourette syndrome had a comorbid pervasive developmental disorder.
Quote:
Variables from logistic modeling that were significant predictors of Tourette syndrome and pervasive developmental disorders were: male gender; no family history of tics/Tourette syndrome; and an increased number of comorbidities (P < .001).
Quote:
We found rates of comorbid Tourette syndrome and pervasive developmental disorders to be increased by 13 times. Identification of differences between subgroups of patients with Tourette syndrome may increase understanding of syndromal susceptibility, severity, and outcome.
Note: this study involved the Tourette Syndrome International Database Consortium Registry.

Lara 04-21-2009 08:10 AM
PubMed Article

J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):13-23.Links
The behavioral spectrum of Gilles de la Tourette syndrome.
Cavanna AE, Servo S, Monaco F, Robertson MM.

Quote:
This paper provides an updated review of the literature on the multifaceted phenotype of Tourette's syndrome, with special attention to the behavioral problems and the relationship between Tourette's syndrome and comorbid neuropsychiatric conditions. The issue of whether Tourette's syndrome should still be considered as a unitary nosological entity is also addressed.

Lara 04-21-2009 08:13 AM
PubMed Article

Mov Disord. 2009 Apr 7
Immunopathogenic mechanisms in tourette syndrome: A critical review.
Martino D, Dale RC, Gilbert DL, Giovannoni G, Leckman JF.

Quote:
Tourette syndrome (TS) has a multifactorial etiology, in which genetic, environmental, immunological and hormonal factors interact to establish vulnerability
<snipped article>

Quote:
Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.

Lara 04-21-2009 08:17 AM
PubMed Article

J Neurol. 2009 Mar 14.
A preliminary study of the frequency of anti-basal ganglia antibodies and streptococcal infection in attention deficit/hyperactivity disorder.
Sanchez-Carpintero R, Albesa SA, Crespo N, Villoslada P, Narbona J.

Quote:
This preliminary study indicates that frequency of ABGA in children with nc-ADHD does not differ from that in matched controls, despite the fact that our ADHD patients had had more recent GABHS infections than the controls. This suggests that ABGA do not have a role in the pathogenesis of nc-ADHD.
Note: small number involved in study

Quote:
We compared 22 children with nc-ADHD (DSM-IV-TR) and 22 healthy controls matched by age, gender and season of sample collection, for the frequency of recent GABHS infection and the presence of ABGA.

Lara 05-22-2009 03:21 PM
Immunopathogenic mechanisms in tourette syndrome
 
http://neurotalk.psychcentral.com/post499139-46.html
I already posted this one but I'll leave it here and quote the material regarding T cells.

PubMed
Mov Disord. 2009 Apr 7.
Immunopathogenic mechanisms in tourette syndrome: A critical review.
Martino D, Dale RC, Gilbert DL, Giovannoni G, Leckman JF.

Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.

<snipped abstract>
Quote:
Finally, a general predisposition to autoimmune responses in TS patients is indicated by the reduced frequency of regulatory T cells, which induce tolerance towards self-antigens. Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.

Lara 05-22-2009 03:23 PM
Immunophenotyping in Tourette syndrome--a pilot study.
 
PubMed
Eur J Neurol. 2008 Jul;15(7):749-53. Epub 2008 May 15.
Immunophenotyping in Tourette syndrome--a pilot study.
Möller JC, Tackenberg B, Heinzel-Gutenbrunner M, Burmester R, Oertel WH, Bandmann O, Müller-Vahl KR.
Department of Neurology, Philipps-University, Marburg, Germany

Lara 05-22-2009 03:25 PM
Decreased numbers of regulatory T cells
 
PubMed
Biol Psychiatry. 2007 Feb 1;61(3):273-8. Epub 2006 Sep 25.
Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study.

Kawikova I, Leckman JF, Kronig H, Katsovich L, Bessen DE, Ghebremichael M, Bothwell AL.
Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut

<snipped article>
Quote:
CONCLUSIONS: These data support our hypothesis that at least some TS patients may have a decreased capacity to inhibit autoreactive lymphocytes through a deficit in T reg cells. Interactions of host T cell immunity and microbial factors may also contribute to the pathogenesis of TS.
http://linkinghub.elsevier.com/retri...06322306008043


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