Articles, Abstracts and News Reports on TS

Lara · 07-06-2007, 11:07 PM

Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics: AHRQ Executive Summary
http://effectivehealthcare.ahrq.gov/...nal_Report.pdf
Full Text pdf
This is very long, but worth reading if you're interested. Just use the search feature to highlight keywords in the file e.g. Tourette's syndrome or Autism or PTSD etc..

from

Medscape Medical News
07/06/2007
Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics: AHRQ Executive Summary
http://www.medscape.com/viewarticle/559169_1

Lara · 08-10-2007, 04:27 PM

PubMed Abstract

Curr Opin Neurol. 2007 Aug;20(4):470-6.
Surgery for other movement disorders: dystonia, tics.
Hamani C, Moro E.

Quote:

PURPOSE OF REVIEW: Various movement disorders are now treated with stereotactic procedures, particularly deep brain stimulation. We review the neurosurgical treatment of dystonias and tics, focusing mainly on the surgical aspects and outcome of deep brain stimulation.

RECENT FINDINGS: Pallidal stimulation is nowadays the mainstay surgical treatment for patients with dystonia, particularly generalized dystonia. Various well designed recent clinical trials support the efficacy of the procedure. Improvements of 40-80% have been reported in primary generalized, segmental and cervical dystonia. For secondary dystonia, a similar outcome has been described in patients with tardive dystonia and pantothenate kinase-associated neurodegeneration. In patients with Tourette's syndrome, the results of the first trials with thalamic and pallidal deep brain stimulation have been very promising. Improvements of 70-90% in the frequency of tics have been reported with surgery in both targets.

SUMMARY: Deep brain stimulation has become an established therapy for dystonia and is currently being used to treat Tourette's syndrome. With accumulation of experience, clinical features that are more responsive to surgery and the best surgical candidates will be revealed. This will likely improve even further the outcome of surgery for the treatment of these disorders.

PMID: 17620884 [PubMed - in process]

PubMed Abstract
Curr Neurol Neurosci Rep. 2007 Jul;7(4):278-89.
Limbic, associative, and motor territories within the targets for deep brain stimulation: potential clinical implications.
Sudhyadhom A, Bova FJ, Foote KD, Rosado CA, Kirsch-Darrow L, Okun MS.

Quote:

The use of deep brain stimulation (DBS) has recently been expanding for the treatment of many neurologic disorders such as Parkinson disease, dystonia, essential tremor, Tourette's syndrome, cluster headache, epilepsy, depression, and obsessive compulsive disorder. The target structures for DBS include specific segregated territories within limbic, associative, or motor regions of very small subnuclei. In this review, we summarize current clinical techniques for DBS, the cognitive/mood/motor outcomes, and the relevant neuroanatomy with respect to functional territories within specific brain targets. Future development of new techniques and technology that may include a more direct visualization of "motor" territories within target structures may prove useful for avoiding side effects that may result from stimulation of associative and limbic regions. Alternatively, newer procedures may choose and specifically target non-motor territories for chronic electrical stimulation.

PMID: 17618533 [PubMed - in process]

http://www.neurology.org/cgi/content/full/68/2/85
NEUROLOGY 2007;68:85
© 2007 American Academy of Neurology
January 9 Highlight and Commentary
Deep brain stimulation for a teen with tics?
Donald L. Gilbert, MD, MS

Quote:

This report describes short-term changes after deep brain stimulation (DBS) in a 16-year-old boy with unusually severe Tourette syndrome (TS) symptoms.1 The report illustrates important factors in considering DBS as an experimental treatment for TS.

http://jnnp.bmj.com/cgi/content/abst...e2=tf_ipsecsha
Tourette’s syndrome and deep brain stimulation
J L Houeto, C Karachi, L Mallet, B Pillon, J Yelnik, V Mesnage, M L Welter, S Navarro, A Pelissolo, P Damier, B Pidoux, D Dormont, P Cornu and Y Agid

http://www.neurology.org/cgi/content...e2=tf_ipsecsha
NEUROLOGY 2006;66:E12
NeuroImages
Hemi tics and deep brain stimulation
Catherine L. Gallagher, MD, P. Charles Garell, MD and Erwin B. Montgomery, Jr, MD

http://www.touchbriefings.com/pdf/2785/tipuaziz.pdf
Deep Brain Stimulation—Which Patients and When?

Lara · 08-10-2007, 04:29 PM

PubMed Abstract

J Intellect Disabil Res. 2007 Aug;51(Pt 8):620-4.
An individual with Gilles de la Tourette syndrome and Smith-Magenis microdeletion syndrome: is chromosome 17p11.2 a candidate region for Tourette syndrome putative susceptibility genes?

Shelley BP, Robertson MM, Turk J.

Quote:

This is the first published case description in the current literature of the association of definite Gilles de la Tourette syndrome (GTS) and the Smith-Magenis syndrome (SMS), both confirmed by DSM-IV-TR criteria and molecular cytogenetic analysis, respectively. The co-occurrence of GTS, SMS and their common behavioural/neuropsychiatric abnormalities should warrant further genetic investigation of chromosome 17p11.2 deletion site as it may be a promising region for containing a gene(s) of aetiological importance in the development of the GTS phenotype. Alternatively, the co-occurrence may be due to the common endophenotypic mechanisms shared by these disorders, rather than being specific for GTS that could be explored using strategies of quantitative trait loci - endophenotype-based approach. Research into this genomic region may also benefit psychiatric genetic research in enhancing understanding of the biological and molecular underpinnings of common behavioural problems that are seen in both GTS and SMS. This would lead to advancement in neurobehavioural/neuropsychiatric genetics which will help in further explaining the broader perspective of gene-brain-behaviour interrelationships.

PMID: 17598875 [PubMed - in process]

Lara · 08-10-2007, 04:36 PM

PubMed Abstract

Clin Genet. 2007 Jul;72(1):1-8.
Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders.
Di Cristo G.

Quote:

GABAergic interneurons powerfully control the function of cortical networks. In addition, they strongly regulate cortical development by modulating several cellular processes such as neuronal proliferation, migration, differentiation and connectivity. Not surprisingly, aberrant development of GABAergic circuits has been implicated in many neurodevelopmental disorders including schizophrenia, autism and Tourette's syndrome. Unfortunately, efforts directed towards the comprehension of the mechanisms regulating GABAergic circuits formation and function have been impaired by the strikingly heterogeneity, both at the morphological and functional level, of GABAergic interneurons. Recent technical advances, including the improvement of interneurons-specific labelling techniques, have started to reveal the basic principles underlying this process. This review summarizes recent findings on the mechanisms underlying the construction of GABAergic circuits in the cortex, with a particular focus on potential implications for brain diseases with neurodevelopmental origin.

PMID: 17594392 [PubMed - in process]

Full text article is available at cost from here. I just posted this one because I thought some people might be interested.
Full Text available

Lara · 08-10-2007, 04:43 PM

PubMed Abstract

Proc Natl Acad Sci U S A. 2007 Aug 6; [Epub ahead of print]
Development of distinct control networks through segregation and integration.
Fair DA, Dosenbach NU, Church JA, Cohen AL, Brahmbhatt S, Miezin FM, Barch DM, Raichle ME, Petersen SE, Schlaggar BL.

Quote:

Human attentional control is unrivaled. We recently proposed that adults depend on distinct frontoparietal and cinguloopercular networks for adaptive online task control versus more stable set control, respectively. During development, both experience-dependent evoked activity and spontaneous waves of synchronized cortical activity are thought to support the formation and maintenance of neural networks. Such mechanisms may encourage tighter "integration" of some regions into networks over time while "segregating" other sets of regions into separate networks. Here we use resting state functional connectivity MRI, which measures correlations in spontaneous blood oxygenation level-dependent signal fluctuations between brain regions to compare previously identified control networks between children and adults. We find that development of the proposed adult control networks involves both segregation (i.e., decreased short-range connections) and integration (i.e., increased long-range connections) of the brain regions that comprise them. Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome.

PMID: 17679691 [PubMed - as supplied by publisher]

Full Text article should be available here and also at PubMed Central, although I can't get it working at present myself.
http://www.pnas.org/cgi/reprint/0705843104v1

Lara · 08-10-2007, 06:32 PM

Olanzapine (Zyprexa)

PubMed Abstract

Psychiatr Prax. 2007 Jul;34(5):253-4.
[Gilles-de-la-Tourette Syndrome as a Tardive Dyskinesia.]
[Article in German]

Kozian R, Friederich M.
Asklepios-Fachklinik Stadtroda.

Quote:

Following ten years of continuous olanzapine therapy a 51 years old man developed a Gilles de la Tourette syndrome which disappeared after changing to amisulprid. The Tourette-syndrome will be attributed to a tardive dyskinesia induced by olanzapine.

PMID: 17597439 [PubMed - in process]

Lara · 08-16-2007, 03:57 PM

Medical News Today article...
Neurology / Neuroscience News
Article Date: 07 Aug 2007
http://www.medicalnewstoday.com/articles/78872.php
Deep Brain Stimulation And Tourette Syndrome

Quote:

Still considered experimental, the procedure used-Deep Brain Stimulation (DBS)-involves the implantation of electrodes in the brain that are stimulated by a surgically implanted pulse generator in the upper chest. Several studies have shown that this surgical intervention may aid in the amelioration of involuntary movements in patients with Parkinson's Disease and Essential Tremor. More recent studies have shown promise for other disorders including Dystonia.

Quote:

Early experience with DBS for tics in TS has been mixed. While some individuals have experienced a reduction in symptoms, others have not. There is no long-term follow-up yet to indicate whether or not symptoms will return at some point. It should be understood that when undergoing this procedure, there might be serious risks involved that could include cerebral bleeding and infection.

Quote:

Only rigorous, methodologically sound scientific study of DBS will provide the answers we seek.

____________________________

TSA-USA Statement: Deep Brain Stimulation and Tourette Syndrome
Following is a statement from TSA Medical and Scientific Advisors.
http://www.tsa-usa.org/news/DBSStatement.htm
(I notice this Statement has been updated 8/2007)
____________________________

PubMed Abstract
Mov Disord. 2006 Nov;21(11):1831-8.
Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome.
Mink JW, Walkup J, Frey KA, Como P, Cath D, Delong MR, Erenberg G, Jankovic J, Juncos J, Leckman JF, Swerdlow N, Visser-Vandewalle V, Vitek JL; Tourette Syndrome Association, Inc.

Department of Neurology, University of Rochester, Rochester, New York, USA.

Quote:

In response to recent publicity regarding the potential use of deep brain stimulation (DBS) for reducing tic severity in Tourette's syndrome (TS), the Tourette Syndrome Association convened a group of TS and DBS experts to develop recommendations to guide the early use and potential clinical trials of DBS for TS and other tic disorders. The goals of these recommendations are to ensure that all surgical candidates are (1) fully informed about the risks, benefits, and alternative treatments available; (2) receive a comprehensive evaluation before surgery to ensure that DBS is clearly the appropriate clinical treatment choice; and (3) that early clinical experience will be documented publicly to facilitate rational decision-making for both clinical care and future clinical trials.

PMID: 16991144 [PubMed - indexed for MEDLINE]

CaitlinP51 · 01-15-2014, 12:29 PM

Excited to read some good information on TS.. thank you!

Lara · 01-24-2014, 05:24 PM

Neuron

Volume 81, Issue 1, 8 January 2014, Pages 77–90

Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
http://www.sciencedirect.com/science...96627313010040

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TSA News
New Findings Shed Light on the Genetics of Tourette Syndrome
http://tsa-usa.org/news/0114ToureteS...wFindings.html

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Yale News
http://news.yale.edu/2014/01/08/yale...rette-syndrome

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NINDS news article
http://www.ninds.nih.gov/news_and_ev...20Syndrome.htm

Adding on an old related post as I couldn't edit it to add on this new info...

http://neurotalk.psychcentral.com/post791641-65.html
l-Histidine Decarboxylase and Tourette's Syndrome

Lara · 01-31-2014, 03:19 PM

Interesting article from PsychCentral regarding ADHD and communication difficulties.

ADHD Associated with Communication Problems

http://jslhr.pubs.asha.org/article.a...icleid=1795793
Referential Communication in Children With ADHD: Challenges in the Role of a Listener
Elizabeth S. Nilsen; Leilani Mangal; Kristi MacDonald

http://jad.sagepub.com/content/17/7/589.abstract
Communicative Perspective-Taking Performance of Adults With ADHD Symptoms

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