Check out this article on BCAA's, Branched Chain Amino Acids. It sounds promising. The BCAA are ingested and help the brain recover a balance of GABA and glutamate.

I think you forgot to post the article. Can you please post? Thanks.

Somehow, the link did not get posted. Either an organic error or an electronic error. Who knows?

Here it is http://www.sciencedaily.com/releases...1207151218.htm

Here is a link to the orginal scientific paper:
http://www.pnas.org/content/107/1/36...a-7b06e4193fc2

thanks mark interesting study,

I tend to dismiss reported cognitive findings in mice as return of instinct, but the regeneration of tissue is interesting
due to my csf leak I have been looking into studies of the fluid as a transmitter

also honey as a potentizer in sugar transported drug

fats eg omega fatty acids as a transporter

this was an interest of mine many years ago when I lived in nz, I applied for a job as a chemical process engineer with a company that was refining manuka essential oil plus other oils and adding it to honey to make a kind of super manuka honey which is effective against msra, I didn't get the job and had forgotten until just now, if I had got the job I would not be typing this post, funny old world ain.t it

also of note is the administering orally in water, in homeopathy there is a theory of dilution eg pure H2O having no trace elements present carries drugs much more efficiently by bonding to the molecules without impairment, since we are 80 % water this seems to make sense

it would be interesting if the BCAAs compounds are present in csf if so what effect they would have in dilution if applied directly into the csf reticular system

thought I would add this artical on CSF so you know what I am babbling on about





The cerebrospinal fluid (CSF) system functions to provide nutrients to and to remove waste products from the brain. Recent findings suggest, however, that in addition, the CSF contains message molecules in the form of actively released neuroactive substances. The concentrations of these are variable over time and between locations, suggesting they are important for the changes in brain activity that underlie different brain states, as reflected by different sensory input and behavioral output relationships. The cranial CSF displays a rapid caudally-directed ventricular flow followed by a slower rostrally-directed subarachnoid flow (mainly towards the cribriform plate and from there into the nasal lymphatics). Thus, many brain areas are exposed to and can be influenced by substances contained in the CSF. In this review we discuss the production and flow of the CSF, including the mechanisms involved in the regulation of its composition. In addition, the available evidence for the release of neuropeptides and other neuroactive substances into the CSF is reviewed, with particular attention to the selective effects of these on distant downstream receptive brain areas. As a conclusion we suggest (1) that the flowing CSF (the third circulation) is involved in more than just nutrient and waste control but is also used as a broadcasting system to send coordinated messages to a variety of nearby and distant brain areas, and (2) that the local release into the CSF and the rapid distribution of specific contents via the CSF can be considered as a special form of volume transmission, which contributes to non-synaptic communication processes in the brain and underlies changes in behavioral states.