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Vitamin B-6
Are there any guidelines about the safe doses of Vitamin B-6? I am a bit confused: some of you mentioned taking 50mg or 100mg daily, and many products offer high doses (I was for instance considering this supplement: Daily Essential Nutrients - A Natural Alternative For Mood Disorders, which would provide 66mg per day), but in my home country the official recommendation is to avoid exceeding 5mg per day because of the potential neurotoxicity.
Is it sensible to take B-12 and B-6 separately, in order to get a high dose of B-12 and a low of B-6? Or is the balance important? |
B-6 at 5 mgs per day is OK. It is the B-12 that is more important. Folate (folic acid) is also important. Getting the whole range of Bs with low dose B-6 is a challenge. That is why I suggest a B-50 Complex plus B-12.
100 mgs of B-6 daily is considered the very lowest range for toxicity with B-6 not usually a problem until 1000 mgs per day is taken. That Daily Essential Nutrients is killer expensive at $1.50 US per daily dose (4 capsules each day). It only has 23 mgs of B-6 in a daily dose of 4 capsules. |
Thank you, Mark.
Actually, the Daily Essential Nutrients is even more expensive than you think since the recommended dose is 4 capsules 3 times per day, which amounts to $4.50 daily (and 69mgs of Vitamin B-6 daily). |
Very confused on the vitamins. My son is 14 months in from his TBI and 4 craniotomies. I bought the Mega mens, D3, N12, B50, C, E, to start but now read it can cause diarea?
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Where did you read about diarrhea from vitamins?
High dose vitamin C can cause diarrhea but that is usually 4 to 6 grams, 4000 to 6000 mgs or more, per day. 1000 mgs a day or even twice a day should not be a problem. This is referred to as bowel tolerance. If the bowels get loose, one just reduces the dose. The regimen should not cause diarrhea. Magnesium oxide is a laxative for some. The other forms of magnesium are better. I get mine from VitaCost.com. Just placed an order. Start an account and get on the emailing list and they will notify you of discounts. Start an order but leave it uncompleted over-night and they will email you a code for a 10% discount to finish ordering. The only thing I do not get from VitaCost is Vit E and NSAIDS. Walgreens has good values for those. |
Leaky Gut Brain Damage Connection
My mini bio
----------- I was a college dropout, I got a job at a factory. I hit my head on long 12 inch metal spikes that hung down from the ceiling in the walkin freezer. I woke up on the floor, no one around. I could barely walk,talk,think. Everybody asked me what was wrong? I couldn't remember exactly. I went home, then next morning I couldn't stand for a few hours, everything seemed to move three feet to right on me. I phoned a local medical organization and asked for a family doctor. They assigned me an ear,nose and throat doctor ENT. (I have since been told by College of Physicians that he could NOT diagnose a head injury stroke, it wasn't his fault) The ENT looked in my ear and insisted my problem was ear infection.(I never even mentioned my ears, I had no ear pain or discharge) I was in such a daze I simply couldn't think straight. I assumed the doctor was right. For almost five months I went exactly every 7 days to this doctor. He would have kept me going back every 7 days forever, but my brother said to ask for specialist. I was sent to eye specialist then ear specialist, but no problem was found. So they concluded I must have psychiatric problems. The factory was forced to lay me off, since I could not function. I didn't understand why I was dizzy 24 hours a day 7 days a week permanently now. I and other family members assumed I was just mentally lazy and now stupid. I could no longer do simple math or read and lost 75 percent of my abilities. I also coincidently had severe digestion, metabolisim problems, running fever,weak immune system, unable to keep muscle on my body. Out of neccesity I created workbooks of drills. Drills for reading comprehension,math, writing, reading out loud. Four hours every night for seven years. I relearned some things but have never got back most of what I lost. Not to mention severe immune system weakness and damaged digestive system, autoimmune disorders. Autoimmune disorders are mostly,mostly misdiagnosed as depression. But depression is merely a symptom of autoimmune disease. Why? basically I believe for two reasons one it generally weakens the immune system, the other is that the Gut and digestion system are linked to the brain. Affect one and you affect the other. 20 years later I was working part time as cleaner in Hospital. I started to describe my medical history to a nurse. Immediately she asked"did you talk and walk like a drunk?" I said "yes". Did you hit your head at any time? I said "yes, how did you know that?" She goes"you just described a stroke and probably brain damage" I found another nurse, then another, then another, eight nurses all said the same thing. I said"you mean to tell me, it wasn't an ear infection?" Then they said"what kind of doctor would say that?" I kind of had a mental breakdown and went into state of shock and deep depression. I started to go to psychiatric therapy. I was in and out from there for about 5 years with many sessions. I tried 17 different anti depressants but ended up in emergency 35 times? They almost literally killed me. The psychiatrists couldn't understand how someone taking only 1/4 of the smallest pill could react like I had taken 100 times the dosage? I've had maybe 1000 autoimmune flareups over the last 30 years(which almost killed me). But according to a rheumatologist and two G.P.'s high fever and arthritis are merely sypmptoms of depression? The autoimmune flareups seemed to almost kill me each time. I submitted that I had a metabolisim problem that magnified the negative of affects of medication and unless that gets addressed first that I could not take meds. The psychiatrists literally laughed. I said I believe there are thousands of causes of depression, like there are thousands of bricks in a wall. I said I believe my problem is partly due to a physiological problem. The doctors disagreed. ---- 25 years ago I convinced a doctor to give me protein metabolisim test. Since I couldn't keep any muscle on my body and my digestion and immune system was so bad. The doctor got the results and literally said "its impossible, no one has results this bad, you'd be really really sick if this was true, just ignore the test results and pretend you never took this test and go home" So I did. Thru trial and error and neccessity I experimented and tried various supplements and herbs and nutrition. I couldn't understand how my head injury resulted in severe digestion and bowel problems. I found various herbs and supplements and foods to help a lot. I shared this information with countless doctors, neurologists, directors of brain damage support groups etc etc. They all said "its all theoretical" I disagreed. 18 years ago, I discovered NAG, which forces the Gut to secrete mucous, temporarily alleviating Leaky Gut or perforated bowels. It not only boosted my immune system but for some reason boosted my Cognitive abilities!!! Why would something that prevents leaky gut also have a major cognitive boost? I looked it up on the internet but found nothing. I later tried Carnosine, which affects the bowels as an antinflamatory but also the brain. Its a wonder supplement. Currently I take Glucosamine(cheaper than NAG) and Natto. I cannot afford Carnosine, but its a super duper wonder cure! I found a dollar store that sells a multimineral supplement that contains zinc plus copper(since you need both) I take Zinc 3 times a day now and it also helps leaky gut a lot! I also take about 8000mg astragalus(most powerful immune booster) Could not substances like glucosamine or NAG combined with Carnosine/zince/copper be used to treat other Cognitive problems? Like Autoimmune diseases? Autisim, Brain Damage, Encephalitis, Turrettes syndrome etc etc??? Curiously a few months ago I discovered this article. This person seems to have learned many things I also was discovering? Brain Injury Rehabilitation through Nutrition and Supplementation - Learn how to Feed a Brain! ** |
*** I forgot to mention. Since some brain injury has leaky gut syndrome,
I've personally noticed my metabolisim results in either poor or hyper absorption. For instance medications I usually cannot take, its like I've taken 100 times more than normal. Also my multimineral supplement contains iodine. Iodine has a cognitive affect which is good but for me and my leaky gut, after taking 1100mcg for a couple of weeks I get Hyper Hyper anxiety!!!! I noticed a lot of people talking about B6. 30 years ago I tried taking it,well the 3 different types of B6 that were available. Because of my leaky gut I believe had I had strange reactions. I tried several other companies, no additives etc, all same reaction. My arms felt like the nerves in them were becoming petrified or solid. This shouldn't happen to most people, except I believe it was my leaky gut resulting in strange absorption. Many strange absorption affects from many substances, Ginkgo resulted in muscles spams in my eyes and everything tasted like salt. |
Link between increased B6 & B12 with lung cancer in male smokers
If you're a smoker, you might want to be aware of this (and stop smoking!). The following link is to a summary of a large scale study that examined long term high dose of B6 and B12. It's an observational study. By nature, the study can't conclude that long term high dose of B6 and B12 promotes lung cancer. However, it certainly suggests that male smokers have a significantly greater chance of getting lung cancer if they supplement with higher B6 and B12 long term. The study does NOT conclude that non smoker males have a higher risk of cancer.
The main point of my post is that - if you smoke - and supplement with extra B6 and B12, observational study indicates you're at increased risk of getting lung cancer. I imagine most people here don't, but if you do, then here's another reason to quit. ** |
After 5 months recovery and some research I thought it may be good to get some feedback on the supplements I’m taking and suggestions for anything additional that people have found to have a positive effect to their recovery.
My symptoms are a general feeling of disconnection from that doesn’t interfere with cognitive ability which I have associated with brain fog or depersonalisation. An EEG scan showed slowing in the left anterior regions of theta waves - not sure if this is something that can be improved with supplements or if it’s something I will live with and is what is causing the feeling of disconnection. My current routine is:
Supplements I'd like to know more about:
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Lecithin is worthwhile. The phosphatidylcholine has a lot of online hype and is expensive. Taking lecithin to support normal production of phosphatidylcholine would be more my objective.
Curcumin in a concentrated extract form with black pepper extract (Bioperine) is also good. Most curcumin is low dose because it is unconcentrated turmeric. Vitacost has a good concentrated curcumin in their house brand. CBD is questionable. It offers a lot of promise but is not a cure-all that many claim. The researched therapeutic dose is quite high, $30 a day or more. I would love to have an opportunity to try it. It is just so expensive and illegal in Idaho. |
I had previously felt an improvement in my concentration and length of time thinking prior to mental fatigue with the B12 cyanocobalamin (swallowed) whereas the under the tongue B12 mecobalamin doesn't seem to have the same effect.
My research hasn't found anything compelling regarding the ingestion by either swallowing or under the tongue. Does anyone else have a similar experience? Maybe I have to wait a while to "load" due to the change in the type of B12? |
If cyanocobalamin works for you, great.
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Hi Mark, I just checked out this post that you talked about in my thread dealing with Venlafaxine. I might give this a try. Thank you!!
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Does anyone have experience with the following:
I had begun to look into Lipoic Acid following reading some information on a different part of this forum and wondering if it's potential benefits could relate to concussion recovery. The same goes for ginkgo biloba which I having been looking into because of claims of improved cognitive function. I'd like to hear from anyone who has used these supplements. |
The studies do not show ginko to have a benefit. ALA may but since it is usually acquired by ingesting a proper and brain healthy diet, some of us do not see the purpose of such a supplement
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I have been taking 400 mg Vitamin B2 (neurologist advised), 120 mg Ginkgo Biloba, Ginseng 75 mg, Vitamin B6 50 mg and C0-Q10 50 mg (these all recommended by Dr Diane website. Are these ok to be taking as well as your recommended daily ones or are there any red flags with these? P.S. Thanks for your input! |
The B-2 is fine. The B-6 is in a B-50 Complex. No need to take more than the amount in the B-50 Complex. Gingko and gensing are OK but not miracle supplements like some claim. The most important is the B-12, folic acid, D-3 and Omega 3 fish oil/DHA.
Dr Diane is OK but very focused on exaggerating her qualifications. She misses many issues and is overly focused on others. IMO, she is more of a profiteer than an expert. |
Just found this- seems to have good info -
Cognitive Function and Brain Health - Scientific Review on Usage, Dosage, Side Effects | Examine.com Ginseng 75 mg seems very low to me.. it that per day? Not sure what type you are using but there are differences between types - [Recommended dosage, active amounts, other details Panax Ginseng tends to be taken in doses of 200 to 400mg daily for general 'preventative' medicine, although some studies on the inclusion of Panax Ginseng in a multivitamin suggest doses as low as 40mg might be bioactive. The 400mg dose appears to confer most cognitive benefit. These doses refer to standard 'Ginseng Extract' which is around 2-3% total Ginsenosides, and is a once daily dosage.] Panax ginseng - Scientific Review on Usage, Dosage, Side Effects | Examine.com |
I just added 5-htp to my vitamin regime. When is the best time to take this? With a meal or without? Also, if I am taking 50 mg right now but I'm going to bump up to 100 mg, should I take both pills at once or one at night one in the morning?
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***Correction I made a typo, instead of glucosamine its supposed to be Glutamine, sorry.
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Mushrooms, oils and nervine herbs
Hi kind ones, I was on auto-pilot, barely improving, for 18 months before a physio therapist literally held my hand towards MCT oil. My brain fog went away in 20 minutes, and everything changed after this! I had enough clarity to even consider taking supplements. Highly recommend these:
Other supplements I take religiously:
Finally, I want to point out that GABA and KavaKava were working for me... until they didn't. At some point they started to pull me down and I felt overwhelmed, so I stopped taking them and only take them on weekends or as needed for stress. |
Hey guys my daily regimen is:
Vitamin B12 (Methylcobalamin) 1000mcgs with 250 mcgs folic acid Vitamin B-Complex containing: B1 4,2 mgs B2 4,8 mgs B6 6 mgs B12 3 mcgs Folic acid (B9) 400 mcgs B3 36 mgs B5 18 mgs Omega-3-6-9 Magnesium 245 mgs Calcium 400 mgs Vitamin D3 5 mcgs Vitamin C 37 mgs Curcumin 700mgs What would you add to this or is there anything you would change? Thanks! |
Hello Everyone.
I would appreciate if someone could take the time to review my current vitamin and supplement regime and provide some suggestions on what to add. Current Regime ----------------- 2 x tablespoon of BulletProof Brain Octane Oil daily Nature's Own Activated Methyl B12 (1000mcg) Nature's Own Concentrated Fish Oil - Concentrated omega 3 (1000mg) - Omega 3 marine triglycerides (630mg) - EPA (310 mg) - DHA (210 mg) Blackmores Vitamin D3 (1000IU) Swisse Men's Power Ultivite (high potency multivitamin) -VITAMIN B1 (thiamine) 120 mg (from thiamine hydrochloride 134.55 mg) -VITAMIN B2 (riboflavin) 120 mg -NICOTINAMIDE 240 mg -VITAMIN B5 (pantothenic acid) 120 mg (from calcium pantothenate 130.99 mg) -VITAMIN B6 (pyridoxine) 50 mg (from pyridoxine hydrochloride 60.77 mg) -VITAMIN B12 (cyanocobalamin) 240 mcg -VITAMIN A (retinyl acetate) 750 mcg RE -VITAMIN D3 1000 IU (as cholecalciferol 25 mcg) -VITAMIN E 50 IU (as d-alpha tocopheryl acid succinate 41.33 mg) -BIOTIN 100 mcg -VITAMIN K (phytomenadione) 50 mcg -CHOLINE BITARTRATE 120.35 mg -INOSITOL 50 mg -FOLIC ACID 500 mcg -LYSINE 50 mg (from lysine hydrochloride 62.47 mg) -TAURINE 75 mg -SELENIUM 50.7 mcg (from selenomethionine 126 mcg) -MOLYBDENUM 100 mcg (from molybdenum trioxide 150 mcg) -MANGANESE 1 mg (from manganese amino acid chelate 10 mg) -IRON 5 mg (from iron amino acid chelate 25 mg) -COPPER 140 mcg (from copper gluconate 1 mg) -ZINC 8 mg (from zinc amino acid chelate 40 mg) -CHROMIUM 3.98 mcg (from chromium picolinate 32 mcg) -IODINE 76.45 mcg (from potassium iodide 100 mcg) -SPEARMINT OIL 2 mg thoughts --------- -firstly I think i'd be a wise idea to incorporate 5-HTP into my regime. I have been considering taking SSRI's for a couple weeks now and would like to try some other alternatives. -is my Swisse Multivitamin giving me enough of all the B's? -Curcumin. I've heard its good for inflammation. -Magnesium Citrate -anyone had any luck with Ginseng? Any other suggestions would be greatly appreciated. Many thanks |
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In many cases Cognitive Behavioural Therapy is highly effective in management of MDD with no need for pharmacological intervention. |
I was on many of the supplements listed here. I've since stopped because I find that they didn't do a thing, weaned myself off one by one and there was little to no effect. They are unregulated, expensive and some of the absorption rates were so low that it wasn't worth it especially with omega 3 pills. Instead I eat all natural and include healthy fats. The last supplement I took was vitamin B2 and found that most ended up in my urine. Replaced it with nutritional yeast.
beef fat and other animal fats MCT oil Nutritional yeast walnuts salmon spinach, kale oatmeal omega 3 eggs cauliflower and broccli carrots beets peanuts |
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