There has been some media about a large South Korean study (published in the British Medical Journal) suggesting that the combination of NSAIDs (pain-killers) + anti-depressants (any type) can increase the risk of intracranial bleeding, esp. in men. Will not include links here, as the headlines are all pretty sensationalized, but easy to Google.

Independent from this, the US FDA has also recently strengthened warnings about NSAIDs, which many people take for things like neck and back pain.

While this has raised further questions and prompted calls for further research, doctors are being advised to closely monitor drug interactions, & pharmacists are being urged to educate patients.

Probably worth letting doc/pharmacist know if you are taking or thinking of taking this combination so that alternatives may be considered.