My comment was in response to Gerd and stomach issues. The blood thinning is another issue. I bleed like a stuck pig.

Aspirin and NSAIDs will cause stomach bleeding systemically, not just locally.

It does this by inhibiting the Cox-1 enzyme in fatty acid chemistry.
Cox-1 is responsible for maintaining the mucus coat of the stomach and its integrity from acid. Removing it, leads to
erosions and damage, and ulcers. This is a systemic effect exerted by aspirin in the blood stream affecting the cells lining the stomach. Just like the proton pump inhibitors reduce acid production systemically the same way (not locally on the stomach lining itself). Proton pump inhibitors, are enteric coated to escape stomach acid which deactivates them.

Aspirin also has effects on clotting and platelets. This can encourage a bleed that has started in the stomach, by thinning the blood.

Thank you again for your replies. I dont understand the tremendous pain at brain stem/spine intersection after all these years. The cymbalta and neurontin definitely help. I know it sounds crazy but the pain shoots out from there to arms, shoulderd, face,tailbone...crazy.

markneil, I'm no doctor of course, but did you ever read up about the Thalamic Pain Syndrome and Dejerine-Roussy Syndrome and the types of pain associated with that?
I think you already did that a few times in the past, but just thought I'd remind you. Look up Dysesthesia and see if that makes sense too.

Thanks. I was diagnosed with thalamic syndrome but I didn't think i met the exact criteria. I guess maybe the doctor was right. I will look into the other thing you mentioned. Thanks.

I use a lot of turmeric. The meds are bad for healing, and cause tennitus

for mark

Central Pain Syndrome from NORD
NINDS Central Pain Syndrome Info

Boy, that sure sounds like what I have. I have not been treated with a variety of the drugs mentione and will see neuro to discuss it. Thanks.

Define "regular basis" and where is the bleeding taking place?

I take 6 Indomethacin a day for a total of 150mg a day... I have been for about a month now... how would I know about the bleeds?

Feeling concerned...

http://www.pdrhealth.com/drugs/indocin

http://www.drugcite.com/?q=indomethacin
These numbers seem small because very few people today use indomethacin regularly. Doctors just will not give it. It remains the most dangerous NSAID.

This site give actual statistics for all NSAIDs... but it is from the late 90's...
http://americannutritionassociation..../deadly-nsaids

The drug industry tried to reduce this risk by making Cox-2 types, to spare the Cox-1 effects. But this failed and all but Celebrex were recalled. The Cox-2 blocking types, Vioxx and Bextra created heart attack and stroke, because there is a vital Cox-2 cytokine made in the kidney that dilates blood vessels, (a beneficial effect)....called prostacyclin. Most of the Cox-2 cytokines are involved however in inflammation. So the strong Cox-2 blockers were taken off the market. Celebrex remains, and contains the warnings for heart disease, but it has been a rather weak Cox-2 blocker.

Indomethacin remains for certain types of headache, and for short term (a few days) treatment for gout attacks, but is rarely used today because of its risks. Indocin is given to newborns to close a patent ductus --a blood vessel that is supposed to close on its own after birth. This vessel bypasses the lungs in utero.
http://americannutritionassociation..../deadly-nsaids

However, indomethacin has potentially terrible side effects, and some doctors use alternate NSAIDs for patent ductus.
http://emedicine.medscape.com/articl...nt#aw2aab6b6b2

The brand name Indocin oral form is no longer available in the US. Only generics. This is because of liability factors. It was originally marketed by Merck.