Also, Mark, Phentermine and Topamax are now being prescribed in combination for weight loss, typically in one pill form called something liked "Qysmia." The combination is very effective. But that uses Topamax at about 46-50mg/day.

But those studies I was looking at showed that when taken at levels exceeding 300-600mg/day then Topamax can cause mental confusion. This happens at rates of like 5-6% of study participants and the higher the dose the worse the side effects. At the weight loss dose, no cognitive side effects were ever reported.

But even if there was a relationship that doesn't explain hypersensitivity to sound and anxiety and many of the other symptoms of PCS either.

(Oh, and by the way, I was sharing that article w my wife last night and came across another part I highlighted that said another study showed promise for Use of Topamax to treat social anxiety disorder too... Interesting)

Chronic use of Topamax can lead to glaucoma and kidney stones.

About 30% of patients have lowered bicarb levels, and this can occur at any dose at any time during use. (not just in the beginning).

http://www.fda.gov/downloads/Drugs/G.../ucm054728.pdf

So regular visits to the eye doctor is recommended, and also tests for serum electrolytes including bicarbonate.

Just FYI

Here is the link to the article mentioned by Lawyer1732 above...

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707352/

Ther Adv Neurol Disord. Jul 2013; 6(4): 211–227.
doi: 10.1177/1756285613481257
PMCID: PMC3707352

Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity

Barbara R. Sommer,corresponding author Erica L. Mitchell, and Tonita E. Wroolie