Traumatic Brain Injury and Post Concussion Syndrome For traumatic brain injury (TBI) and post concussion syndrome (PCS).


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Old 01-05-2015, 04:31 PM #1
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Question Has anyone tried Acethylcholine supplements?

Acethylcholine is the most important neurotransmitter for brain regulation. It helps keep the brain balanced and organized.

A deficiency of Acethylcholine is known to cause the following symptoms:

• Cognitive impairment
• Brain fog
• Difficulty concentrating
• Poor decision making
• Intolerance to emotional stress
• Confusion
• Sleep problems
• Poor short term memory

Acethylcholine, right after a brain injury, rises dramatically and quickly in the brain and that might lead to a downregulation of the nicotinic receptors (the receptors that Acethylcholine binds to). A downregulation of nicotinic receptors which might be caused by excessive Acethylcholine release after a concussion might lead to the symptoms written above.

Acethylcholine is extremely important for cognition, as I've stated, and it's well known for lifting brain fog.

So, has anyone here tried Acethylcholine increasing supplements? If you did, did you notice an improvement in your recovery?

Thanks,
-ProAgonist
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PCS sufferer (18.2 years old male).

Concussions:


27 October 2014 - I accidentally smashed my head against a concrete wall while I was running (it was a slow run of about 3 meters / second).
No LOC.

6 November 2014 - In a sports field, A basketball ball fell on my head from about 5 meters height.


January 2, 2016 update: I am very optimistic, as I've made a significant recovery until now (2-Jan-2016). I am confident that my situation will keep improving.
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Old 01-05-2015, 08:48 PM #2
Mark in Idaho Mark in Idaho is offline
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Pro,

Why are you asking about this when you have not even started the suggested vitamin and supplement regimen ? Most people start with the simple stuff before adding the more specific supplements.

One web site says this "Take a daily vitamin B complex supplement. Purchase a supplement that contains vitamin B1, vitamin B6 and vitamin B12, all of which are critical to the synthesis of acetylcholine."
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Last edited by Mark in Idaho; 01-06-2015 at 12:35 AM.
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Old 01-06-2015, 03:17 AM #3
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Quote:
Originally Posted by Mark in Idaho View Post
Pro,

Why are you asking about this when you have not even started the suggested vitamin and supplement regimen ? Most people start with the simple stuff before adding the more specific supplements.

One web site says this "Take a daily vitamin B complex supplement. Purchase a supplement that contains vitamin B1, vitamin B6 and vitamin B12, all of which are critical to the synthesis of acetylcholine."
I'm asking because I've read online a bit about Acethylcholine and it sounds like this is the most important neurotransmitter to recovery for a concussed brain.

One of the main problems after a concussion is with brain regulation, and Acethylcholine is responsible for brain regulation, so it just makes sense that Acethylcholine supplements can help PCS sufferers.
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PCS sufferer (18.2 years old male).

Concussions:


27 October 2014 - I accidentally smashed my head against a concrete wall while I was running (it was a slow run of about 3 meters / second).
No LOC.

6 November 2014 - In a sports field, A basketball ball fell on my head from about 5 meters height.


January 2, 2016 update: I am very optimistic, as I've made a significant recovery until now (2-Jan-2016). I am confident that my situation will keep improving.

Last edited by ProAgonist; 01-06-2015 at 03:40 AM.
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Old 01-06-2015, 04:22 AM #4
Mark in Idaho Mark in Idaho is offline
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If the brain can produce its own acetylcholine if it has the proper building blocks, why not give it those building blocks. Those building blocks also help other chemical systems. Oh yea, those building blocks are B12, B-6 and B-1.

It is always better to help the brain function properly than it is to short circuit the chemical systems with substances that take the place of the brain doing its job.
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Old 01-06-2015, 07:02 AM #5
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Choline is the precursor for making acetylcholine.

Foods remain the best source for this.
Here is a list:
http://nutritiondata.self.com/foods-...000000-1w.html

You can see egg yolks are very high.

There are drugs called acetylcholine agonists... these are reserved for dementia patients. They have serious side effects including vomiting and diarrhea. I don't think you mean these.

Most lecithin supplements are omega-6's in an oil form, and that would skew your Omega-3 ratio further in favor of inflammation so are not a good idea.

Some health food stores sell lecithin granules, which you can use but they go stale very quickly. Deteriorate rapidly in hot environments. Keep in the frig therefore
http://www.drugstore.com/products/pr...la&kpid=320139

Foods high in choline are your best bet. Some children's vitamins now contain choline.
This is what Dr. Weil says about choline:
http://www.drweil.com/drw/u/ART03240/Choline.html

I would caution against eating beef brains however, as the risk of prion disease is too high. Liver also is problematic as toxins accumulate in liver.

Two eggs each morning would be very easy to do and very inexpensive, however. In the US we have Omega-3 eggs too...like Eggland's best.
http://www.egglandsbest.com/
But there are other brands now.
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Old 01-06-2015, 11:25 AM #6
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I wasn't talking about Acethylcholine agonists, I was talking about supplements that are responsible for the manufacturing of Acethylcholine.

Also, Acethylcholine agonists don't have to be medications for dementia. Nicotine is an Acethylcholine agonist, although it might have addictive properties so it shouldn't be used as a treatment.

Are there pills containing choline? (Like there are pills with Omega 3 or vitamins)
__________________
PCS sufferer (18.2 years old male).

Concussions:


27 October 2014 - I accidentally smashed my head against a concrete wall while I was running (it was a slow run of about 3 meters / second).
No LOC.

6 November 2014 - In a sports field, A basketball ball fell on my head from about 5 meters height.


January 2, 2016 update: I am very optimistic, as I've made a significant recovery until now (2-Jan-2016). I am confident that my situation will keep improving.
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