A question to all who took amitryptiline

Canadoc · 02-17-2015, 05:55 PM

Quote:

Originally Posted by Griffin17

Canadoc, thanks for your good explanation.

If I understood you right, amitryptiline can on the one hand supress TBI symptoms (because of it's effect on the receptors), but on the other hand it also acts sedative. This means that some people could indeed miss the point where they healed their TBI because the drug makes them still feel tired, exhausted or dazed(I often heard the term 'zombie feeling').

At the moment, I feel like I'm in no man's land, because I feel like a zombie, not knowing wether it comes from my injury or the drug.

And because of that I'm definately planning to stop taking the drug by slowly reducing the dose over a few weeks. (how long does this sedative effect last, after one has stopped to take it?)

You talked about genetic factors. Well my father also took it, maybe he had the same feelin as I have. I will talk to him.

The sedating side-effects should all but disappear after 24-36 hours unless you are taking another medication that is slowing down the metabolism of amitriptyline (unlikely). If you are still feeling drowsy after 36 hours, I would for another cause.
P.S. you are correct in saying that some people may misinterpret medication side-effects for persistent mTBI symptoms. The only way to find out is to do a trial discontinuation of the drug (under the guidance of your physician of course).

Canadoc · 02-17-2015, 06:05 PM

If mTBI sufferers are experiencing relief of pain symptoms with this drug but are troubled by oversedation, an alternative is to try Nortriptyline. In actual fact, when Amitriptyline is metabolized in the liver, it becomes Nortryptiline. Eventually Nortryptiline is itself metabolized by the liver on its way to be deactivated. Just a thought. Cheers, Canadoc

Chris2828 · 02-18-2015, 11:43 AM

Canadoc, I will see my neuro on tuesday. Then I will discuss with him how we should proceed with the drug.

Thanks for your help!

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