Traumatic Brain Injury and Post Concussion Syndrome For traumatic brain injury (TBI) and post concussion syndrome (PCS).


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Old 10-07-2017, 03:58 AM #11
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A PubMed search for "ketogenic diet" returns 2118 papers.

A search for "ketogenic diet" and "traumatic brain injury" returns 12 papers.

None of these 12 papers provide clinical evidence that a ketogenic diet is of benefit to people with TBI.

NT members may draw their own conclusions from this.
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Old 10-07-2017, 09:06 AM #12
todayistomorrow todayistomorrow is offline
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Quote:
Originally Posted by kiwi33 View Post
A PubMed search for "ketogenic diet" returns 2118 papers.

A search for "ketogenic diet" and "traumatic brain injury" returns 12 papers.

None of these 12 papers provide clinical evidence that a ketogenic diet is of benefit to people with TBI.

NT members may draw their own conclusions from this.
Dom talks about why there is a lack of studies for Keto and other ailments that it may be helpful for. Originally it was just used medically for epilepsy and the control of seizures and there is numerous research showing the efficacy is better than any drug without the side effects. The problem is it's very hard to do control studies with Keto and the nutrition science in general is way behind what current research is coming out with. Basically the food pyramid is completely wrong and how people view fats. It's not for everyone and some people tolerate carbs ok, but he said it's especially useful for people with deficits as it improved brain metabolism and a host of other functions.

This isn't some fad diet. I get why you might be skeptical and it's important that research be done and is being done currently. Figuring out the optimal macros(fat/carbs/protein) ratio and what the exact levels of ketones in the blood should be for a particular person is areas needed more research. People need to monitor their cholesterol #'s if they take on this diet but all in all, there isn't any downside I see to trying to see if it helps symptoms
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Old 10-11-2017, 11:08 AM #13
Hains Hains is offline
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Quote:
Originally Posted by kiwi33 View Post
A PubMed search for "ketogenic diet" returns 2118 papers.

A search for "ketogenic diet" and "traumatic brain injury" returns 12 papers.

None of these 12 papers provide clinical evidence that a ketogenic diet is of benefit to people with TBI.

NT members may draw their own conclusions from this.
Actually kiwi33, your statement is misleading and untrue.

Firstly, I reproduced your PubMed search using the same search terms you've mentioned above.

One of my search hits was a study by Greco et al titled Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. This study concluded with the following statement:
"These results strongly suggest that ketones improve post-TBI cerebral metabolism by providing alternative substrates and through antioxidant properties, preventing oxidative stress-mediated mitochondrial dysfunction."

Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. - PubMed - NCBI

Secondly, a search with the terms "ketogenic diet" AND "concussion" found an article by Prins and Matsumoto (2014) titled The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury. This study concluded the following:
"Preclinical studies employing both pre- and postinjury implementation of the ketogenic diet have demonstrated improved structural and functional outcome in traumatic brain injury (TBI) models, mild TBI/concussion models, and spinal cord injury."

Thematic Review Series: Calorie Restriction and Ketogenic Diets: The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury


kiwi33, I hope you understand that that people on this form struggle for extended periods of time with PCS as the science is just starting to come out of the dark ages of brain and concussion research. This is evident to everybody who has gone to the doctors office for a concussion and gone home with a useless prescription and no real solutions. Up until the last few years people with brain injuries were dismissed with psychological issues because of naivety and ignorance in the medical community. There is no magical pill or one-off solution to PCS. Many people suffer for years and years with little hope and no good ideas for recovery. It is critically important that we explore options like ketosis, promising new sciences that could offer relief to people who struggle endlessly. Your statement does not support such progress and you offer no alternative solutions, you're just putting up brick walls **

Not every idea is backed by double blind gold standard studies which take years to complete and cost millions of dollars. These types of clinical studies are often only affordable to big pharmaceutical companies who have no interest in suggesting that people change their diet. They want people to be hooked on pills, the evidence is clear. I've seen you chime in on a few different threads for different PCS topics, always with the same negative theme. You should be careful with your statements as they cause one to question your ethics.

Hains

Last edited by Jomar; 10-11-2017 at 11:13 PM. Reason: ** per guidelines
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Old 10-11-2017, 11:32 AM #14
Mark in Idaho Mark in Idaho is offline
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A key issue in each of these studies is the timing of the ketosis. The rats are put into ketosis within hours of the injury. The benefits seen appear to be a result of stopping the cascade of concussion symptoms.

The need for early intervention has been known for at least a decade. The problem is determining which concussion needs the early intervention. Some studies suggest only 1 out of 8 needs early intervention but all 8 would need to be treated with this early intervention to benefit the 1 that needs it.

It would be great to see these rats studies delay ketogenic diets for a few weeks. Allow the cascade to start then see if the cascade can be stopped or reversed.

Hains, Big Pharma could support these studies and sell proprietary forms of exogenous ketones for early intervention. Imagine the market for $500 to $1000 worth of exogenous ketones for every diagnosed concussion.

Now, imagine the health insurance companies saying No, not everybody with a concussion needs this treatment. We will only approve it for the 1 in 8 who do.

I say, Go ahead and promote the ketogenic diet. Just be honest and read the studies and find the specifics of each study. It is easy to control the diet of lab rats who have no ability to eat anything but what is put in their cage. Some are even gastrically fed. To me, is sounds like they would not voluntarily eat the exogenous ketone foods. Would you consume 600 to 1000 grams of exogenous ketones each day? That is 0.5% to 1% of your body weight each day.

Read the studies and find the specifics. It is usually a tough read but with effort, one can find the specifics.
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