NeuroTalk Support Groups - MAGNESIUM Information:

Quote:

Originally Posted by Laurie (Post 89639)

I just scanned through this thread and then looked at the label on the cal/mag product that we are using. It contains Mg Carbonate and Mag Hydroxide in a liquid form. Should I ditch it and buy a different product? I can't find much info on any of these forms of mag.

Thanks,
Laurie

back to this thread.

I'm looking around PubMed today for data on this and another question.

This is a newer paper than I quoted earlier:

Quote:

: Magnes Res. 2005 Dec;18(4):215-23.Click here to read Links
Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach.

* Coudray C,
* Rambeau M,
* Feillet-Coudray C,
* Gueux E,
* Tressol JC,
* Mazur A,
* Rayssiguier Y.

Centre de Recherche en Nutrition Humaine d'Auvergne, Laboratoire des Maladies Metaboliques et Micronutriments, INRA de Theix/Clermont-Ferrand, Saint-Genes-Champanelle, France. coudray@ensam.inra.fr

Literature data on the bioavailability of various Mg forms provide scarce information on the best Mg salt to be used in animal and human supplementation. This study aimed to investigate the bioavailability of different forms of Mg in rats using Mg stable isotopes. Eighty male Wistar rats aged 6 weeks were fed a semi-purified Mg-depleted diet for three weeks. The rats were then randomised into ten groups and received, for two more weeks, the same diet repleted with Mg (550 mg Mg/kg) as: oxide, chloride, sulphate, carbonate, acetate, pidolate, citrate, gluconate, lactate or aspartate. After 10 days of Mg-repleted diet, the rats received orally 1.8 mg of an enriched 26Mg. Faeces and urine were then collected for 4 consecutive days. Isotope ratios in faeces and urine were determined. The Mg absorption values obtained varied from 50% to 67%. Organic Mg salts were slightly more available than inorganic Mg salts. Mg gluconate exhibited the highest Mg bioavailability of the ten Mg salts studied. Urinary 26Mg excretion varied from 0.20 mg to 0.33 mg, and feeding with the organic pidolate, citrate, gluconate and aspartate salts resulted in higher urinary 26Mg excretion than with inorganic salts. Ultimately, 26Mg retention was higher in the rats receiving the organic salts such as gluconate, lactate and aspartate than in those receiving the inorganic salts. Taken together, these results indicate that 26Mg is sufficiently bioavailable from the ten different Mg salts studied in the present experiment, although Mg gluconate exhibited the highest bioavailability under these experimental conditions.

PMID: 16548135 [PubMed - indexed for MEDLINE]

This site give a graph showing absolute % content of some magnesium preparations:
http://ods.od.nih.gov/factsheets/magnesium.asp
You can see that inorganic salts have higher ratios, but according to some
testing being done, have lower absorption ranges.

Typically magnesium hydroxide is in Milk of Magnesia...typically it is not a good source of magnesium, as it is fundamentally a laxative. That means it remains in the GI tract and causes water to enter the gut and effect evacuation.

But people differ. Very constipated people do not mind, if some laxative actions occur. Sensitive people would be troubled by it.

If you have a positive response, feel better, etc..then you are probably getting enough for you. Relaxing muscles, less tension, and sleeping better are signs that magnesium is working for you.

I do like the Ionic Fizz too, but it does loosen me up if I use it every day.

There are also magnesium glycinate products. (not mentioned in the article above)
http://www.ncbi.nlm.nih.gov/entrez/q...t_uids=7815675

Quote:

Data from this study support the suggestion that some portion of magnesium diglycinate is absorbed intact, probably via a dipeptide transport pathway. Magnesium diglycinate may be a good alternative to commonly used magnesium supplements in patients with intestinal resection.

Magnesium gluconate is available OTC as Magonate.

Here is an older article:

Quote:

Magnes Res. 2001 Dec;14(4):257-62. Links
Bioavailability of US commercial magnesium preparations.

* Firoz M,
* Graber M.

Department of Veterans Affairs Medical Center, Northport, NY 11768, USA.

Magnesium deficiency is seen with some frequency in the outpatient setting and requires oral repletion or maintenance therapy. The purpose of this study was to measure the bioavailability of four commercially-available preparations of magnesium, and to test the claim that organic salts are more easily absorbed. Bioavailability was measured as the increment of urinary maginesium excretion in normal volunteers given approximately 21 mEq/day of the test preparations. Results indicated relatively poor bioavailability of magnesium oxide (fractional absorption 4 per cent) but significantly higher and equivalent bioavailability of magnesium chloride, magnesium lactate and magnesium aspartate. We conclude that there is relatively poor bioavailability of magnesium oxide, but greater and equivalent bioavailability of magnesium chloride, lactate, and aspartate. Inorganic magnesium salts, depending on the preparation, may have bioavailability equivalent to organic magnesium salts.

PMID: 11794633 [PubMed - indexed for MEDLINE]

Here is a list of prescription drugs that should not be taken with magnesium hydroxide:

Quote:

Alendronate (Fosamax)
Allopurinol (Zyloprim)
Antibiotics classified as quinolones, such as Cipro and Noroxin
Aspirin
Atenolol (Tenormin)
Captopril (Capoten)
Chlordiazepoxide (Librium)
Cimetidine (Tagamet)
Digoxin (Lanoxin)
Doxycycline (Vibramycin)
Fosfomycin (Monurol)
Gabapentin (Neurontin)
Glipizide (Glucotrol)
Glyburide (Micronase, DiaBeta)
Isoniazid (Rifamate)
Ketoconazole (Nizoral)
Levothyroxine (Synthroid)
Methenamine (Urised)
Metronidazole (Flagyl)
Misoprostol (Cytotec)
Mycophenolate mofetil (CellCept)
Nonsteroidal anti-inflammatory drugs such as Dolobid, Naprosyn and Voltaren
Penicillamine (Cuprimine)
Phenytoin (Dilantin)
Quinidine
Sodium polystyrene sulfonate (Kayexalate)
Sucralfate (Carafate)
Tetracycline antibiotics such as Achromycin V and Minocin
Tilodronate (Skelid)
Ursodiol (Actigall)

One should space these out 2-3 hrs before or after any magnesium product.