The methyl form is one of two types.

The others are dibencozide made by Country Life and a
Few others and hydroxcobalamin which is
More expensive.

These alternate forms are discussed on the B12 thread
at the PN forum.

How did you get so low? The cause may reveal which
Form to use. You must take oral B12 on an empty
Stomach. 3 months of oral is enough time to see
improvements. But if you have the MTHFR mutation
it won't work if cyano form.

Only about 13 mcg are absorbed from 1000 mcg which
Is not much. So you must take it on an empty stomach.

I think what happen to me is that I went on a RAW food diet for about a year. I exercise at a high intensity several times a week. I did not supplement with B12 for a long time, at least a year. I felt great....until I didn't!

I have not had it tested, but everything that I have read and what I have experienced with Methyl B12 leads me to believe that I over-Methylate. What do you think? Also, if I do, is there a better B12 to take that isn't cyano or methyl that wouldn't give me these crazy symptoms? My wife forbids me to take Methyl B12 anymore because it turns me into a monster!

Thank you for your time Mrs. D

I gave you the other names to try
above. Cyano has to be activated to
Methyl in order to work at all.

If you are not converting it you would
Only know from blood testing.

If you are low in methyl folate as well
Because of non conversion due to DNA
Error you would have depression.
Methyl folate is a treatment in high
Dose for depression.

You could try OTC Metafolin by Solgar
and see if that helps your mood. 800mcg
a day.

To find more on over methylation etc.
Search-- Dr Walsh methylation Pfeiffer
That phrase keyword will take you to his
Paper. That is still a theory and some
doctors don't follow it.

It may well be cyano could work for
You... But you will need testing every
3 months or so to determine that.

Thank you Mrs. D. Yes, you did mention the other B12's above and I appreciate that information. But, more specifically I am wanting to know if those other B12's are likely to give me similar symptoms as the methyl version? I am a little hesitant to try anything other than cyano now for fear of the severe negative symptoms.

I have read the Pfeiffer and Walsh material and the over-methylation sounds a lot like me.I still need to get tested though. It is my understanding that if one is an OV that they need to avoid methylated supplements; do you agree with this?

Thank you for your time and patience as this is new territory for me.

Shane

The term as Dr.Walsh uses is
OVER methylation and is a Lack of
Methyl folate methyl B12.

If you read Suzy Cohen's methylation
Blog linked on PN forum there is more
explanation. Methylation is a huge
subject encompassing DNA activity
and mRna. Too many methyl groups
there block normal functions. A drug
Used for bipolar disorder strips these
extra methyls and is called Depakote.

This chemical subject is very complex
And affects many systems.. Not just
The conversion of folic acid and
Cobalamin.

Do the cyano then get tested and see
What happens . The best test is the
DNA screen by 23and me. Some of our
Members have done it and found out
They had the genetic error. People with
This error have high risk for heart attacks
And stroke. So it is very important.

Will do. Thanks.

adenosylcobalamin is another active form of B12 you may be able to tolerate. From what I understand, this form does not seem to work on the CNS/brain the same way that the methyl form does.

I would start at a low dose of 500 and work up to your target slowly. Only increase it if you do well with it for three days.

This is another name for the dibencozide..
I may not be spelling it correctly on this iPhone

Ohhh....thanks. Why can't they just settle on one name for the same thing? Same with drugs. When John was in the hospital, he was on a lot of drugs and I knew the names and dosage. Then when he was discharged, they would write up discharge orders listing the med he was to take. Of course, they used another name for the same drug. Then, when I went to the pharmacy to fill the scripts, the bottles had another. And they wonder why there are so many medication errors when people are discharged from the hospital.

There can be many errors on discharge papers.
I used to see them all the time.

1) Often residents or interns or nurses
would fail to transcribe IV doses
To oral.

2) With antibiotics some IV forms do
Not come orally so another drug would
have to be written instead.

Hospitals are hot beds of errors!

When I had my son they made an terrible
overdose on me. Then after it was
Discontinued, brought it back at 2 am
To give again 2 days later! But I foiled that one!