So happy to read informed replies on B12 deficiency. I have only been treated for around 2 weeks. Have pretty severe polyneuropathy (missed by two docs because my serum level b12 is "normal"). Started with Cobalamin for first 10 days, but luckily was able to get methyl in syringes and am on my 3rd dose.

I want to do everything I can do minimize permanent nerve damage in my legs and feet (which are 100% numb!). Have had mild symptoms for over ten years caused by reflux med.

Question: I am taking Nuerontin (3x per day @300mg) to manage pain and muscle spasms (and, so that I can sleep at night). Would an anti-seizure med like this interfere with effectiveness of the b12 methyl injections?

So, three months later I remembered this thread, and i tought it would be nice to write a update about my problem progress.

The last doc i went to (before start taking B12 pills) diagnosed me with Chronic Fatigue Syndrome, and basically told me that i was going to be that ill my whole life, that there was no treatment for it. Then, he just said he couldn't do anything else for me, told me to have a nice day, handshaked me, and wished me luck. Thanks doc, very useful!

For a 22 years old young man like me (And for my parents, too), you can comprehend how heartbreaking this was. One year ago, i was full of energy and vitality, with dreams and plans for my future, full of hope. Now, just one year later, i was permanently exhausted, depressed, and spent most of my day bedridden. Seemed like i had aged 80 years in just one.

The only thing i didn't lost was hope. When you lost hope, its all over. When you are that ill, the only thing that pushes you forward, the only thing that keeps you alive is simply thinking that everything is going to be ok again. And being told that i was going to be that way for all my life, being told that basically my future was over (Who is going to hire a guy who gets tired just by sitting on a chair for an hour? How im going to travel around the world if i can't barely make it to my house door without feeling a urge to return to the bed again?) made me lost the little hope i had left. And in front of me, in my once bright perception of my future, there was only darkness.

And then i looked at my B12 levels, and i remembered some histories i readed on the internet long ago, about people with my same symptoms. My doc had long ago assured me that B12 wasnt my issue, but... could he be wrong? How could possibly a experienced professional, who had earned his position over years and years of hard work and studying about this subjects, whos speciality was diagnosing rare illnesses, one of the most reputated doctors of my city, how could he possibly be wrong? That was impossible.

But i had nothing to lose, so i found this forum and posted this thread. And your messages gave me hope again. Nobody i told believed it, but i sure did. I needed to.
So I started to take B12 orally daily, 1000mcg. Told my GP about it and he was basically like "whatever, is not toxic, do what you want". I started to take folate too, because i was in the low normal range also.

And, day after day, my tiredness went slowly down.

Three months later, I still have memory problems, yes. But im not tired anymore. I still have some visual problems, but im no longer depressed. I have hope again... and i will travel around the world some day. And my bed isn't going be there to stop me this time.

So, thank you very much for giving me hope when I needed it. And thank you so much for spending your time in a non profit forum, just to give hope to other people like me.

And, for everyone having a bad time now, remember that things get better, they always do. You can do it.

I wish you all a great 2016. Keep going!

wow, that is excellent news. It's really great that you came back to post an update. Take care there!

Whether it is a post explaining the science behind our symptoms or sharing experiences or leading us to truly helpful and trusted information - all who participate on this site are just plain remarkable people.

It is so great that you shared your story and emphasized the importance of staying hopeful. In fact, I believe that hope is the one thing that only we can give to each other ... and I don't believe large doses can be toxic.

Thank you again!