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Vitamin B6 Pyridoxine/P-5-P information:

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Old 02-09-2017, 01:11 PM   #131
mrsD
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Lightbulb re: high blood levels of B6:

This topic has just come up again on our PN forum here. So I did some new searching to update information on this topic:

So here are the links. The first ones deal with high serum levels when no supplements are taken. This topic is all over the web so it has to be affecting many people.

The Cause of Vitamin B6 Toxicity is Not What You Think

[How much vitamin B6 is toxic?]. - PubMed - NCBI

Elevated B6 levels and peripheral neuropathies. - PubMed - NCBI

And this last paper which is a PDF, explains the chemical reactions and binding to pyridoxal kinase, which is the enzyme which activates pyridoxine ( to pyridoxal 5 phosphate). At the end of the paper is a new list of drugs found to impair this conversion (impairing pyridoxal kinase's actions), and has added new drugs to the list which may affect many people.
It has a heading numbered 5.4

http://scholarscompass.vcu.edu/cgi/v...07&context=etd

Quote:
Lamotrigine, theophylline and its structural a
nalogs, including enprofylline,
theobromine and caffeine inhibited hPL kinase
Also if one searches, "drugs that affect pyridoxal kinase" one can find papers suggesting antimalarials mentioned. These are quinoline derivatives, and I suspect fluoroquinolines might be appearing soon in this research as well.

Back when pyridoxal kinase was first being studied, over a decade ago, I only found theophylline listed as a inhibitor of this enzyme.
It appears then, with more time, other drugs will be added as well to this list.
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Old 02-19-2017, 03:49 PM   #132
movedtotexas54
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More than 100 mg a day of Vit B6 can casue damage to the sensory nerve cell bodies and is not recommended. This is well known
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