This topic has just come up again on our PN forum here. So I did some new searching to update information on this topic:

So here are the links. The first ones deal with high serum levels when no supplements are taken. This topic is all over the web so it has to be affecting many people.

The Cause of Vitamin B6 Toxicity is Not What You Think

[How much vitamin B6 is toxic?]. - PubMed - NCBI

Elevated B6 levels and peripheral neuropathies. - PubMed - NCBI

And this last paper which is a PDF, explains the chemical reactions and binding to pyridoxal kinase, which is the enzyme which activates pyridoxine ( to pyridoxal 5 phosphate). At the end of the paper is a new list of drugs found to impair this conversion (impairing pyridoxal kinase's actions), and has added new drugs to the list which may affect many people.
It has a heading numbered 5.4

http://scholarscompass.vcu.edu/cgi/v...07&context=etd

Also if one searches, "drugs that affect pyridoxal kinase" one can find papers suggesting antimalarials mentioned. These are quinoline derivatives, and I suspect fluoroquinolines might be appearing soon in this research as well.

Back when pyridoxal kinase was first being studied, over a decade ago, I only found theophylline listed as a inhibitor of this enzyme.
It appears then, with more time, other drugs will be added as well to this list.

More than 100 mg a day of Vit B6 can casue damage to the sensory nerve cell bodies and is not recommended. This is well known

Hi all,

It's been a while since I last posted on NeuroTalk. I thought I'd share my experience of using (mainly) Pyridoxine Hydrochloride (Vitamin B6).

Here is my story:

I had my first seizure at two weeks old. I spent the first five months of my life in and out of hospital. Doctors were mystified by my illness. None of the ‘normal’ antiepileptic drugs that were administered had any positive effects. At this time I was having many ‘different types’ of seizures a day some of which went status. Countless tests were being done including, EEGs, lumber punctures… etc. A top paediatrician from the main city hospital told my mother that he was going to a meeting. He said he would talk about me in the hope that someone there would be able to help us. At this meeting there was a professor who was doing research into childhood epilepsy. He suggested a trial of Pyridoxine Hydrochloride (vitamin B6). Pyridoxine Hydrochloride was administered (I was almost five months old). Within two to three days my mother noticed a big difference in me. I’d stopped having severe seizures. Because of the positive effects that Pyridoxine had on my seizures doctors slowly weaned me off all the antiepileptic drugs (this was back in 1970-71). I’ve been prescribed Pyridoxine Hydrochloride on a daily bases ever since.

I was still experiencing my (mainly photosensitive) aura when taking vitamin B6 only, so in 1990, with my doctor's consent, I included a multi B complex tablet to my daily medication. This stopped my aura.

'PNPO Deficiency' has now been confirmed via a genetic test.

Regards,

Andrew

**DO NOT ALTER ANY MEDICATION WITHOUT YOUR DOCTOR'S CONSENT**

Bumping up this older thread as it may be helpful to a new member.