Sorry I missed this post some how....

I'd stop all B6, and get retested.

But you know when you are taking vitamins they will show up in the testing as "highs" but you may be having symptoms from something else.

How old are you? Old enough for blood pressure medications?
The dermatological issues may be from something else you are eating or taking in RX medication form?

The prime cause of dermagraphia can be ACE inhibitors used for blood pressure. Angioedema can be from allergies or a condition called hereditary angioedema. The latter is from excess bradykinin and not histamine which is in the allergic type.
They are similar since both chemicals are biogenic amines. But the cause is different. The ACE inhibitors cause a buildup of bradykinin, and if a person is low in C-1 inhibitor, due to genetic reasons, then the excess causes all sorts of symptoms. Swelling of parts of the body, dry cough, difficulty breathing and the skin redness/itching etc are all symptoms. With HAE there are GI symptoms too, pain, cramping diarrhea, vomiting are all possible.

Blood work from labs does not take into account any vitamins you may be getting in food. OTC products like 5 hr energy, energy drinks, fortified cereals, etc can all have B6 in them. The lab ranges vary depending on the lab too. All the ranges were made using "normals" who were NOT taking any B6. Labs make mistakes and miscalibrate machines. Quest did this TWICE and one of those times lasted a whole year with Vit D testing! All their reports for that year were erroneous!

I have on this thread, a paper done on autistic children who were screened prior to B6 therapy...and some were found to be high in B6 already and not using B6 at all. This situation demonstrates that some people may be high in this vitamin, and just not know it. And it calls into question how accurate labs may be or not, and how useful the testing really is. All of the B6 papers I've seen only address intake resulting in symptoms. The blood work often does not make it into the abstracts available on PubMed.

I believe that the testing for B6 tests for all forms in the body, and pyridoxine has 2 other forms that are floating around.
It is possible that handling of the specimen can result in lysis (rupture) of the cells which then spill out their contents into the serum, which is tested. This happens with potassium testing, as well. It is called a factitious result.
http://ajcp.ascpjournals.org/content/131/2/195.full
B6 testing is not that common, and may not have made it to the research level yet, to reveal errors of this type.

Long term high dosing at one time was common, in treatments for PMS in women. Some people were taking 500mg or more a day. This has moved out of the common arena today, so B6 testing is not commonly done. Having a lab do a CELLULAR value would demonstrate more IMO. Only some special labs do this type of nutrient evaluation.

The classic symptoms of B6 toxicity are neurological, with numbness and difficulty walking predominately. Not rashes or hives which suggest allergy or bradykinin issues.

I'd consult an allergy doctor for your skin problems, if you haven't already, and if you have other symptoms that point to HAE, I'd get the testing for that which most immunologists do:
http://emedicine.medscape.com/article/135604-overview
If you don't have Medscape, it is free and easy to sign up for.
Their copyright does not allow for posting their pages here.

Another cause of severe allergic issues is mastocytosis.. and that is genetic too.

Certain foods and families of foods can cause skin reactions.
Histamine releasers and histamine found in food are something you should check, after you look at any RX or OTC drug you may be reacting to:
http://diagnosisdiet.com/histamine-intolerance/

So I do really think you need further evaluation by a doctor specializing in allergies etc.

mrsD,

Thank you for your reply..

Here is additional information about me that address your questions.

1) I am 49 years old male. I don't have blood perssure or diabetes. My cholesterol is borderline high and I used to take Niacin 1000 mg daily for it. It went up when I stoppped niacin for 6 months due to my skin issue and I went back and took niacin and Cholestoff (6 tabs/day). It dropped from 260 to 190 and LDL from 199 to 130.

2) I am not taking any supplements with B6 or any high energy drinks. I used to have a memory/focus pill and Emergen vitamin C drink that has 20 mg of B6 but stopped it a while back. The quantity is also very low to cause a high level of Vitamin B6.

3) I do lots of exercise (5 times/week) doing variety of things. I do have microscopic blood in urine for several years but from what I read this is normal and unrelated.

4) I have seen over 10 doctors and I have lost faith in the medical field. I saw two allergists, four dermatologists, three internists, infectious disease specialist, etc..

They did all kinds of tests and nothing came positive. In fact, one allergist made things worse by the anti bacterial cream he gave me. I also did urology tests thinking some urinary tract infection might cause this but it was not. Some dermatologists suspected Schistosoma (parasitic infection) but I tested for it three times and it was negative.

My diagnosis was "Uriticaria Dermatogrpahia" and the best they can do is prescribe AntiHistamines like Allegra, Doxepin, Zyrtec, Claritin, etc..

5) I did the food and chemical allergy tests and the tests shows some allergies to peanuts and some unknown chemical used in hair dyes.

I know that my case is not related to allergic reaction becaus I had those several times and they would go away when I stop the a supplement or powder.

6) My symptoms (red itchy rash on legs) started after I had some knee pains and I strated taking knee supplement.

I took this this product "ostesport" for 3 months starting in September, 2012

and Flex animal for 2 weeks in December, 2012

Then I woke up with Hives and my skin problems started and it kept coming back in a cycle.


I always suspected that these supplements are the one that caused my condition and I stopped immediately all
kinds of supplements.


I always thought my condition was due to some internal infection (not external skin) like Parasite, Fungus, bacteria.

I started doing the Natural Health treatment. I took Hulda Clark Parasite cleanse and felt a difference after taking the green blackwalnut black hull. This convinced me that this must be some kind of parasite.

from what I read there are 100 types of praasites and labs that do stool or urine tests may not be accurate because it may not exist and they might use a small sample that does not have it and they only look for one type.

The other thing I Suspected was the abnormal high VItamin B6. I am not taking any B6 supplement. Also I do not understand why it is not being excerted with urin since it is water soluble.

I also suspected Liver issue due to High B6 since the liver converts it to P-5-P.
I want to do another test for B6.
Can Labs test for B6 and P-5-P in two different tests? Everytime I ask them They do not seem to know the difference.

Also, B6 is a soluble and should be exerted in urine so I don't understand how can a blood test show high value?

I was also considering MMS (miracle mineral supplement) since it was listed as the best cleanser for parasites.
I have not taken that yet and I noticed that the ban on it.

Both of those supplements you mentioned contain hyaluronic acid.
http://www.wisegeek.com/what-are-hya...de-effects.htm

Hives is a listed side effect for oral use of this compound.

But one would think they would go away as time passes since you used them.

Many cereals, breads, and pasta products are fortified today, and contain the B vitamins. Not in high amounts however.

I would not really focus on the blood work for the B6... you can look on the net and find many people asking the question about being in the high range for it. This begs the question as to how accurate the range really is. The B12 range which is still used goes way down low to levels (200pg/ml) listed as normal...which will produce neuro symptoms in some people (deficiency). (below 400pg/ml).
So the ranges for other nutrients might also be out of date as well.

Dermagraphia is a common sign of HAE:

http://www.asthmacenter.com/index.ph...nd_angioedema/

This allergy link above explains HAE.

I would look to what you consume daily as food. I gave you the links to histamine foods and releasers. Those can cause itching.
Also MSG in processed foods can be very irritating to some people.

The most common infestation in people today is Candida. You can starve this yeast by not eating alot sugar and carbs. There are tests for it too.

An itchy rash also comes from gluten intolerance and Celiac.
Going gluten free may help you too.

mrsD,

It is not histamine intolerance. I never had that before. It is not also food allergy for sure.
I stopped all supplements long time ago too. I only take natural oils now.


this issue is microbe related (parasite, bacteria, fungus, etc). I might have picked them up from these supplements
or another source.

I think they did a blood test once for fungus and candida and it came back negative but I no longer
trust lab results or doctors anymore.

I have been doing 30-day parasite cleansing "purify" and my symptoms are almost gone.
I take some olive leaf extract too.

I have been seeing some strange white things (like mucus) in urine and some things in stool too.
I just have slight skin flakiness but it greatly improved. it seems still healing...

skin marking/dermatography is also less.

I still want to retest for B6. My B12 and eveything else was in normal range.

Can I request labs to test for B6 (non-active form) and pyroxidine?

I want to know if liver is converting the B6 to acitve.

I called a couple of labs and they do not seem to have a clue on pyroxidine.

Hi all,

I would like to share my good news with you. I have been using B vitamins to control my seizures. Vitamin B6 (Pyridoxine) Prescribed for over 43 years. It has now been confirmed, via a genetic test and interesting research, that I have a condition known as 'PNPO Deficiency'. The professor who conducted the genetic research has told me that I am the oldest known person in the world scientific literature with this extremely rare condition.

regards,

Andy

Hi,

I just found this thread, and unfortunately most of the information relevant to my situation is 6+ years old. Hopefully mrsD is still around with all of the excellent information...

A few months ago I noticed petechiae on my thighs. Then my period came early. Then I became exhausted. Then sick and dizzy. Finally just recently, after seeing a dozen doctors and specialists, they've decided that I probably have Hashimoto's, although I don't have the antibodies.

Anyways, a month into this (in June) I woke up in the middle of the night with my left arm numb and tingly and my heart POUNDING. I was terrified and thought I was having a stroke or heart attack. I called the paramedics, went to the ER, and they said nothing was wrong with me. I went home, and it began getting much worse. The numbness in my left arm spread to my right, then into my legs, then feet, then knees, then hips, then my face and the inside of my mouth. I was sure I was developing MS. My GP had no idea what was happening. A week later I call for the results of some labwork I'd had done. I have requested a B6 test, along with B12 and a thyroid panel, and a few other things. I requested B6 because I had read somewhere that it was important for thyroid function.
My B6 was at 76 with the range being 2-29. I began researching, only to find that the numbness was neuropathy, and that it was probably related to the B6. I went in to see a neurologist. I was tested for MS and ALS, negative. Also negative for any LARGE fiber neuropathy, which is useless, as I believe B6 causes small fiber neuropathy.
My only source of B6 was 25mg in a multivitamin I'd been taking for years. I stopped taking it and went on a strict low B6 diet. All numbness faded within 2 weeks. I checked my B6 level again and it was in the low 20s.

That was several months ago and I'm still having some issues getting my thyroid under control, but I have not had any numbness. Recently, my B6 is back up to 29, a couple of points outside of this labs range. I don't know why it would be coming back up.

So my question is, should I start taking P5P? I've had the Organix test done and there were no abnormalities with my B-Complex Vitamin Markers. My folate, B12, magnesium, and homocysteine are all fine. My only issues are the B6 and my low/normal T3 and erratic TSH. I did the 23andMe test and ran it through Genetic Genie and Promethease. I'm hetero for MTHFR C667T and 03P39P, also MTRR A664A. Homo for CBS A360A and VDR Taq.

Mayo's lab tests P5P levels. My immunologist has agreed to try to have my blood sent to them. We're also testing my B2. I suspect I have a deficiency, but if so, would my level drop and symptoms fade when stopping the multi with 25mg pyrodoxine? Would a deficiency that's showing up as elevated pyrodoxine show low levels of P5P when tested or should I be testing something else?

Being heterozygous for methylation genes is a confusing situation.
In some respects these people can appear normal, but the methylation pathways are impaired so that activating B12 and folic acid will not be 100% efficient.

This stuff is highly complex, so I suggest you have an expert help you with your results:

Here is a website link that explains some of the results you have:
http://geneticgenie.org/methylation-analysis-example/

There is another good resource:
http://mthfr.net/

I am not an expert on interpreting genetic results, sorry.

Welcome digifem.