I found this list:

http://www.charcot-marie-tooth.org/med_alert.php

I think "mega" implies the 500mg that was commonly used in the past daily...for PMS and other maladies.

I wouldn't call 50mg a day "mega".

In fact the FDA has approved pyridoxine for pregnant women who have alot of vomiting issues. That dose is 75mg a day.
Metanx has 25mg of P5P (activated pyridoxine) in it. This would be easily equivalent to 50mg of pyridoxine (which is not activated). So it brings to mind the question... is the unactivated form that bothers CMT patients, or the P5P form?
From what I have gathered over the years, the P5P form is safer in people with special needs/problems. The "toxicity" of pyridoxine was only measured with the unactivated form, and is thought to pertain to IT only.

I also found it interesting that fluoroquinolones were classed as
minor. I think these drugs cause PN in many normal people!
They have become a real problem. I think they should be moved up the list.

Thanks for bringing it up, Kitt.